gen patho

Question 1

distributive shock examples

Answer 1

1. neurogenic
2. septic
3. anaphylactic

Question 2

bcl2 function

Answer 2

anti-apoptotic

Question 3

pro-apoptotic genes

Answer 3

bac, bax

Question 4

histo: viral infection

Answer 4

abnormal nuclear inclusions

Question 5

nk cells fight against

Answer 5

intracellular pathogens (virus, parasite leishmania, listeria monocytogenes)

Question 6

ifn alpha targets

Answer 6

virus

Question 7

ifn gamma recruits

Answer 7

macrophages

Question 8

ifn gamma induces production of

Answer 8

IgG2a and IgG3

Question 9

which vaccine causes poliomyelitis

Answer 9

live attenuated (oral)

Question 10

type iv hypersensitivity reactions

Answer 10

t cell mediated, transplant rejection, tb skin test, “touching” contact dermatitis, terminal (delayed)

Question 11

costimulatory domains of CAR T cells

Answer 11

1st gen: CD3
2nd gen: CD3, CD28
3rd gen: CD3, CD28, CD137

Question 12

suppressor T cell

Answer 12

Treg

Question 13

T cell got MHC but no co-stim is what

Answer 13

anergy

Question 14

what Ig can cross placenta

Answer 14

IgG

Question 15

most radio-sensitive organ sites in children

Answer 15

thyroid > breast > bone marrow > brain (most common sites of carcinoma development due to radiation exposure)

Question 16

how do t cells activate macrophages

Answer 16

Th1 secretes IFN gamma and express CD40 ligand

Question 17

how do macrophages kill ingested microbes

Answer 17

• generate ROS + NO
• increase production of lysosomal enzymes + pro-inflammatory molecules
• recruit more leukocytes