Gender

Question 1

What are the goals of gender affirming hormone therapy?

Answer 1

Modify the secondary sex characteristics of the body

Question 2

What is the MOA of GnRH analogues?

Answer 2

Suppress gonadotropin releasing hormone

Question 3

Route of GnRH analogies

Answer 3

Injectable
Implant

Question 4

Side effects of GnRH analogies

Answer 4

Prevents natural gonadal development/fertility while in use

Question 5

What drugs is a GnRH analogies?

Answer 5

Lupron

Question 6

Goals of trans-masculine hormone therapy

Answer 6

Muscular development
Fat redistribution
Deepening of voice
Body and facial hair growth

Question 7

Areas not affected in trans-masculine hormone therapy

Answer 7

Existing breast tissues
Physical size/bone structure

Question 8

Side effects of trans-masculine hormone therapy

Answer 8

Fertility suppression
Mood changes

Question 9

MOA of testosterone

Answer 9

Synthetic testosterone replacement

Question 10

Testosterone routes of administration

Answer 10

Topical
Injectable
Transdermal

Question 11

Side effects of testosterone

Answer 11

Increases risk of heart disease and diabetes to that of cis men
Increases red blood cell counts
Birth defects
Liver damage
Hair loss

Question 12

MOA of finasteride

Answer 12

Blocks production of DHT responsible for terminal hair loss

Question 13

Finasteride route of administration

Answer 13

Oral

Question 14

Side effects of finasteride

Answer 14

Decrease prostate-specific antigen
Effect on sexual function

Question 15

What medications are progestin contraceptions?

Answer 15

Norethindrone
Medroxyprogesterone

Question 16

MOA of progestin contraception

Answer 16

Synthetic progestin compounds use negative feedback to halt ovulation cycle

Question 17

Patient education for progestin contraception

Answer 17

Must be taken at the same time each day, otherwise spotting can occur
Cycle cessation can take 2-3 months
Testosterone alone can’t prevent pregnancy

Question 18

Permanent changes induced by testosterone

Answer 18

Bigger clitoris
Deeper voice
Gradual growth of mustache and beard
Hair loss at temples and crown of head
Thick, coarse hair on abdomen, arms, back, chest, and legs

Question 19

Not permanent changes induced by testosterone

Answer 19

Acne
Menstrual stopping
More abdominal fat - changing from pear to apple shape
More muscle mass and strength
More sex drive
Vaginal dryness

Question 20

Goals of trans-feminine hormone therapy

Answer 20

Breast development
Fat redistribution
Skin and hair changes
Mood changes
Decrease/cessation of hair loss

Question 21

Side effects of trans-feminine hormone therapy

Answer 21

Change/decrease in libido or sexual function
Fertility suppression

Question 22

Areas not effected by trans-feminine hormone therapy

Answer 22

Voice
Facial hair follicles
Physical size/bone structure

Question 23

MOA of estrogen

Answer 23

Synthetic estrogen replacement

Question 24

Estrogen routes of administration

Answer 24

Oral or sublingual
Transdermal
SQ or IM

Question 25

Side effects of estrogen

Answer 25

Liver damage Increased risk of breast cancer to that of cis women Increased risk of VTE

Question 26

Permanent changes induced by estrogen

Answer 26

Breast development

Question 27

Non permanent changes induced by estrogen

Answer 27

Slow in growth/changes in body hair Less fat on abdomen and more on buttocks - apple shape to pear shape Male pattern baldness cessation Softer skin Loss of strength/muscle mass and tone Fertility suppression Decrease or change in libido Changes in mood

Question 28

MOA of spironolactone

Answer 28

Aldosterone antagonist Has anti-androgenic effects at higher doses

Question 29

Spironolactone routeofadministration

Answer 29

Oral

Question 30

Side effects of spironolactone

Answer 30

Dehydration Frequent urination Gynecomastia Reduction in male fertility Possible serum electrolyte imbalances - low sodium high potassium

Question 31

Bicalutamide MOA

Answer 31

Testosterone blocker Medication binds to testosterone tissue receptors

Question 32

Bicalutamide routes of administration

Answer 32

Oral

Question 33

Side effects of bicalutamide

Answer 33

Liver toxicity Reduction in fertility and erectile ability

Question 34

Which medications are progesterone?

Answer 34

Micronized progesterone Medroxyprogesterone

Question 35

MOA of progesterone

Answer 35

Synthetic progesterone replacement for libido or breast development

Question 36

Progesterone routes of administration

Answer 36

Oral Topical