General

Question 1

What is defective in chronic granulomatous disease?

Answer 1

NADPH oxidase

Question 2

What defect is common in SCID?

Answer 2

Adenosine deaminase deficiency and ***

Question 3

What are some anti-inflammatory cytokines?

Answer 3

TGF-B and IL-10

Question 4

Recurrent infections with neisseria is often caused by what defect?

Answer 4

Defect in ability to form MAC (membrane attack complex); complement deficiency (C5-C9)

Question 5

Fas is involved in what pathway?

Answer 5

Apoptosis!

Question 6

CD40/L is involved in what pathway?

Answer 6

Class switching

Question 7

What cytokines stimulate Th2 differentiation?

Answer 7

IL-4

Question 8

What cytokines stimulate Th1 differentiation?

Answer 8

IFN-gamma and IL-12

Question 9

Reactive arthritis - what are the 3 components?

Answer 9

Urethritis, arthritis (often sacroiliitis), conjunctivitis

Question 10

Every MHC I molecule contains what?

Answer 10

Heavy chain + beta-2 microglobulin

Question 11

Every MHC II molecule contains what?

Answer 11

Alpha and beta polypeptide chains

Question 12

What cytokine is responsible for class-switching to IgE, and what type of response is it associated with?

Answer 12

IL-4, IgE

Question 13

What cytokine is responsible for differentiation of hematopoetic stem cells?

Answer 13

IL-3

Question 14

Macrophages secrete what cytokine and enhance what type of response?

Answer 14

IL-12, Th1

Question 15

What cytokine is secreted by Th2 T cells and what does it inhibit?

Answer 15

IL-10, inhibits IFN-gamma, decreasing Th1 response

Question 16

What cytokine is secreted by CD4+ cells and functions to promote IgA synthesis and eosinophil activation?

Answer 16

IL-5

Question 17

How is secretory IgA synthesized?

Answer 17

Dimer (synthesized by plasma cells), connected by J chain (synthesized by epithelial cells)

Question 18

What cytokine is responsible for neutrophil chemotaxis?

Answer 18

IL-8