General Flashcards

(591 cards)

1
Q

Which tumours are associated with adrenal metastasis?

A

Lung and breast

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2
Q

Adrenaline vs Noradrenaline

A

Adrenaline Alpha and Beta Noradrenaline predominantly alpha Alpha - peripheral vasoconstriction Beta - cardiac chronotropic and inotropic

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3
Q

What is dopexamine

A

Splanchnic vasodilator

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4
Q

Scaly, thick and greasy appearance.

Keratin plugs

A

Seborrhoeic Keratoses

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5
Q

Name 4 clinical features of a mass/swelling that make it suspicious of being a sarcoma

A

> 5cm soft tissue mass

Deep / Intramuscular Location

Rapidly Growing

Painful

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6
Q

Ewings vs Osteosarcoma

A

Ewings is a diaphyseal, small round tumour.

Radiologically - Onion Skin appearance- represneting lysis with periosteal elevation.

Osteosarcoma is usually a tumour of the metaphysis (osteoblastic cell origin)

Radiologically - sunburst appearance = sclerotic destruction

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7
Q

Discuss Anterior Interosseus Nerve

Topography

Innervation

A

Topography:

Branch of the emdian nerve —> travels along anterior interossues membrane of the forear between flexor pollicus longus and flexor digitorum profondus ending at pronator quadratus

Innervates:

Flexor Pollicis Longus

Pronator Quadratus

Radial Half - FDP

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8
Q

Anion Gap

Calc

Causes

A

Calculation (Na+K+)-(Cl+HCO3)

Normal 10-18

Low Anion Gap

hypoalbuminaemia, increased cations (MG++, Ca++, IgG),

Normal Anion Gap - Hyperchloraemic

Bicarb Loss, Renal Tubular Acidosis (moreso in type II), Drugs (Acetozolamide), Chloride Injection, Addison’s Disease (Type IV RTA)

High Anion Gap

Lactate, Ketoacidosis, Urate, Exogenous Acids

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9
Q

Causes of delayed gastric emptying

A

Neuronal:

Vagotomy, Diabetic Gastroparesis (Vagal Nerve Disruption)

External Compression:

Pancreatic masses abutt the duodenum thereby delaying ewmptying,

Internal Obstruction:

Distal Gastric Malignancies, Pyloric Stenosis

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10
Q

Ileostomy

Location

Construction

Complications

A

Location: Triangle between ASIS, Umbilicus and symphysis pubis.

Construction: 2cm incision, stoma length 2.5 cm, spouted, one third between umbilicus and ASIS.

Complications: Dermatitis, necrosis, prolapse, retraction, high output

Normal stoma output: 5-10 ml/kg/24 hour period. If >20 ml/kg/24 hour period —> IV fluids and supplementation

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11
Q

Vagina lymph vessel drainage:

Superior

Inferior

A

Superior - drain into the internal + external iliac nodes

Inferior - drain into the superficial inguinal nodes

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12
Q

Contents of jugular foramen

Bones forming jugular foramen

A

Bones: Posterior Occipital bone + Petrous portion of temporal bone

Contents - CN IX, X, XI. Inferior Petrosal Sinus, Sigmoid Sinus, Meningieal arteries (from occipital and ascending pharyngeal artery)

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13
Q

Contents of Superior Orbital Fissure

A

CN III, IV, VI

Recurrent meningeal artery

Superior Opthalmic Vein

V1 - Lacrimal, Frontal and Nasociliary

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14
Q

What do each of these secrete:

Parietal Cells

Chief Cells

Surface Mucosal Cells

A

Parietal Cells - HCl, Ca, Na, Mg, IF

Chief Cells - Pepsinogen

Surface Mucosal Cells - Mucus and Bicarbonate

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15
Q
A
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16
Q

Dep Peroneal nerve

Course

Action

What (sometimes) atraumatic condition can it become compromised in?

A

L4-S2

Branch of common peroneal nerve at lateral aspect of fibula. Travels in anterior leg comparment. passes ankle anteriorly between two malleoli where it bifurcates:

Pre - Bifurcation: - Tibialis anterior, enxtensor hallucis longus, extensor digitorum longus, peroneus tertius

Lateral - Branch supplies extensor hallucis brevis and extensor digitorum brevis

Medial - cutaneous branch innervating skin at the webspace between 1st and 2nd digits

Acts to - evert foot, dorsiflex ankle and extend toes

It can become compromised in compartment syndrome of the anterior compartment

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17
Q

Berry’s Sign

A

Absence of carotid pulse due to thyromegaly

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18
Q

Thyroid Malignancy:

Psammoma Bodies

Skull Metastases

Elderly females

A

Pappilary - Psammoma Bodies. Picked up via FNA

Lymphatic spread

Follicular - Not well picked by FNA –> need hemithyroidectomy. Haematogenous spread (bones)

Anaplastic - Elderly females. Poor prognosis. palliative debulking

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19
Q

Otosclerosis

Patho

Treatment

A

Fixation of stapes to oval window

Treatment involes stapedectomy + prosthesis insertion

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20
Q

Pethidine caution in…

A

Renal patients

It has a toxic metabolite which accumulates in renal dysfunction —> Muscle twitching and convulsions

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21
Q

Pharyngeal Pouch

A

True diverticulum (Zenker’s)

Involves all layers of mucosa.

Posteromedial herniation between thyropharyngeus and cricopharyngeus

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22
Q

Discomfort after eating - think..

A

Chronic Mesenteric Ischaemia

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23
Q

Mesenteric Vascular Disease

A

Acute Mesenteric Ischaemia - Embolic. Sudden onset pain, vomiting and diarrhoea

Acute on chronic - Post-prandial discomfort –> Acute

Mesenteric Venous Thrombosis –> Picture of weeks. Symptoms present when arterial inflow is compromised

Low flow mesenteric infarction –> inotrope use, intercurrent cardiovascular compromise

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24
Q

Describe rectus sheath

A

Above costal margin –> Aponeurosis of external oblique aponeurosis

Between costal margin and arcuate line –> Anterior rectus sheath - External oblique aponeurosis + anterior internal oblique aponeurosis. Posterior rectus sheath- Posterior internal oblique aponeurosis + Transversus abdominus

Below arcuate line –> There is no posterior rectus sheath. External and internal oblique aponeurosis alongside transversus abdominus form anterior rectus sheath. posterior to this is transversalis fascia then peritoneum.

Arcuate line is 1/2 between umbilicus and pubic crest

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25
Transfusion protocol in major haemorrhage due to trauma
1:1:1 - Packed Red Cells, FFP and platelets
26
**What are adrenal rests**
Adrenal rests - ectopic adrenal tissue. Commonly located on broadligament or spermatic cord.
27
Extensor retinaculum Attachments Structures superficial to retinaculum Tunnels Tendons (8)
**Attachments** - Medial - pisiform and triquetral Lateral - Radius **Superficial structures -** Basilic + cephalic vein Dorsal cutaneous branch of ulnar nerve Superficial branch of radial nere **Tunnels** - 6 tunnels in total. **Tendons-** Enxtensor Carpi Ulnaris, Extensor Digiti Minimi, Extensor Digitorum and indicis, extensor pollicis longus, extensor carpi radialis longus tendon, extensor carpi radialis brevis tendon, abductor pollicis longus, extensor pollicis brevis tendon .
28
What muscles are innervated by median nerve Forearm Distal forearm Hand
Forearm - Pronator teres, flexor carpi radialis, palmaris longus, flexor digitorum superficialis, flexor pollicis longus, flexor digitorum profondus (radial half) Distal forearm - palmar cutaneous branch Hand - LOAF - Lateral 2 lumbricals, opponens pollicis, abductor pollicis previs, flexor pollicis brevis Sensory innervation to thumb and lateral 2.5 fingers
29
Management of Renal Cell Carcinoma
T1 Malignancy - Partial Nephrectomy + Adjuvant chemotherapy T2 Malignancies - Total radical nephrectomy. Patients need early venous control prior to resection to rpesent tumour seeding.
30
**JVP** Absent a waves Large a waves cannon waves prominent v waves slow y descent steep y descent JVP rises during inspiration Fixed Raised JVP
Absent A Waves - AF Large A Waves - Right ventricular hypertrophy, triscupid stenosis Cannon Waves - Complete Heart Block Prominent v waves - Tricuspid Regurgitation Slow y descent - Tricuspid stenosis, Right Atrial Myxoma Steep y descent - Right ventricular failure, Constrictive pericarditis, Tricuspid regurgitation JVP rises during inspiration - Kussmaul's sign of constrictive pericarditis Fixed Raised JVP - Superior Vena Cava Obstruction
31
**Factors favouring EVAR**
Long neck of aneurysm (For fusiform aneurysms - neck is the unaffected proximal portion of artery) Good Groin Vessels Straight Iliac Vessels
32
Billous Vomiting in Neonate - Rule out Briefly describe embryological problem What happens in the abdomen Investigations
Intestinal Malrotation (+volvulus) Normal **embryology** involves intestine entering abdominal cavity at 4 weeks --\> Then a 270 degree rotation so the: - caecum is in the RLQ - DJ flexure is to the left of vertebrae In intestinal malrotation - there is a missing 90% rotation --\> the duodenal loop is adjacent to the caecum with Lads Bands fixing it in place. **Then** the intestine undergoes 720 degree rotation --\> volvulus. Investigations : US - Abdomen: See where the SMA is in relation to the SMV (Normally SMA on left of SMV) Contrast abdominal scan: see where the DJ flexure is (usually to the left of vertebral bodies)
33
**What is the ligament of treitz**
Ligament of Treitz: Suspensory ligament arising from right crus of diaphragm and attaching at the DJ flexure and usually at the 3rd + 4th parts of duodenum
34
Microscopic difference between Thyroid: Follicular Adenoma Follicular carcinoma
Carcinoma has invasion of the capsule whereas adenoma do not.
35
**Posterior Interossus Nerve** Origin Topography Muscles Innervated
Origin - Division of the radial nerve (occurs by lateral epicondyle between brachialis and brachioradialis) Crosses supinator where it formally becomes the posterior interossues nerve Innervates - Supinator + Extensor carpi ulnaris **Extensor** digitorum, indices, digiti minimi, extensor pollicis longus + brevis, abductor pollicis longus
36
**Testicular Tumours** **RFs** **Investigations**
RFs- Cryptorchidism, Kinefelter's, Infertility, FH, Mumps orchitis Investigations - US, Tumour markets, CT- TAP for staging Classically Categorised: Seminoma (40 year olds) - AFP -ve, HCG \<20% +ve, LDH \<20% +ve Germ Cell (non-seminoma) (\<30 year olds) - 70% AFP +ve, 40% HCG +ve
37
Cranial Nerve IX and X Muscle exceptions
IX - This innervates Stylopharyngues - muscle for swallowing. **All other pharyngeal muscles are innervated by Vagus nerve** This is because the stylopharyngeus develops from III pharyngeal arch. CN IX is also developed from this arch. X - Cricothyroideus is innervated by the external laryngeal nerve. **All other laryngeal muscles are innerated by Recurrent laryngeal nerve** This is because Cricothyroideus originates from arch IV alongside the vagus nerve. the RLN originates from arch VI
38
**Causes of dysphagia**
Extrinsic: Mediastinal Masses, Cervical Spondylosis Oesophageal Wall: Achalasia, Diffuse oesophageal Spasm, Hypertensive Lower Oesophageal Sphincter Intrinsic: Stricture, Schatzki Ring, malignancy, Oesophagal Web Neurological: CVA, Bulbar Palsy, Multiple Sclerosis, Parkinson's Disease, Myasthaenia Gravis
39
On Sentinel Node Biopsy of breast what might you find?
Isolated Tumour Cells or Evidence of Micrometastases **Isolated Tumour Cells -** Do not require axillary clearance **Micrometastases -** Depends on the extend of nodes involved. If there are lots of suspect nodes then FNA of theese nodes is the first thing to do. In practice --\> Positive SNLB usually equates to axillary node clearance
40
**Current best practice.** **Varicose Veins** i) Investigation ii) Treatment
i) hand held doppler and then Venous Duplex ii) 1- Endothermal Ablation 2- Sclerotherapy 3 - surgery (trendelenberg procedure)
41
**Obturator Nerve** Roots Topography Actions
Roots - L2 ,3 and 4 Topography - roots combine in psoas major and descend to lateral sacral margin --\> Cros sacroiliac joint --\> Descend through obturator internus entering the obturator groove. Lies lateral to internal iliac vessel + ureter Actions - Cutaneous - Medial thigh Motor - External obturator, Adductor magnus - upper portion, Adductor Longus, Adductor Brevis and gracilis.
42
**Options if common bile duct has been opened/damaged?**
i) T Tube insertion and closure of the bile duct over it ii) Cholecoduodenostomy iii) Cholecojejunostomy
43
**Options for relieving malignant obstructive jaundice (pancreatic head ca / cholangiocarcinoma)**
i) ERCP ii) PTC + Drainage + Stent Insertion
44
Tongue Lymph Drainage
Anterior two thirds: Ipsilateral Drainage Posterior Third: Bilateral Drainage Tip of tongue: Submental --\> Deep cervical Midtongue: Submandibular --\> Deep cervical Posterior tongue: Deep cervical
45
**Tongue innervation + Nerve topography**
Anterior Two thirds: **Lingual nerve -** originates as a branch of mandibular nerve (V3). passes tensor veli palitini --\> joined by chorda tympani (facial nerve CN VII). Courses by junction of vertical/horizontal mandibular ramus --\> passes by the third molar . The Trigeminal Portion --\> Sensation (General Sensory) The Facial Portion --\> Taste (Special Sensory Posterior Third **Glossopharyngeal nerve -** Sensation + Taste (General and special senory)
46
Why may you have a normal ph acute mesenteric emobolus?
The bowel infarct --\> Lowers pH Vomiting --\> Raises pH
47
**Four mechanisms of vomiting**
**Gag** - Touch Receptors in throat (CN IX), Pharyngeal Cosntrictors (CNX + CNIX for stylopharyngeus) **Labyrnthine** disorders - Motion Sickness **Stomach and duodenal distension -** stretch receptors **Central (brain) -** chemically induced (drugs etc.)
48
**PR Bleeds** **Source**: Darker Blood Dark Blood Fresh red Blood Melaena **Investigations**
Darker Blood - Right sided bleed Dark Blood - Left sided bleed Fresh red Blood - Distal bleeding (haemorrhoids) Melaena - Upper GI **Investigations:** When blood --\> Flexi Sig first. If no lesion then consider colonoscopy When blood + unstable --\> Stabilise + CT Angio When melaena --\> OGD
49
**When to admit for acute lower GI bleeding**
Age \>60 Significant Co-Morbidity Unstable Profuse bleeding Aspirin/NSAID use
50
**Surgical options for splenic flexure malignancies:** **Obstructed** **Non-Obstructed**
**Obstructed** - i) Stenting ii) Extended Right Hemicolectomy. This involves taking the middle colic vessels (SMA) too unlike a right hemicolectomy. An ileo-colic anastamosis is fashioned. In general when performing resective colorectal surgery the arteries are followed and taken to ensure lymph nodes are removed as these are usually in close proximity to the arteries. Non-obstructed - i) Extended Right Hemi ii) Left hemi iii) Transverse colectomy (old-fashioned)
51
**Rectal Cancer** What is the margin requirement What precludes the use of Anterior Resection What is TME What surgery for obstructed rectal cancer What additional treatment can be offered to rectal cancer patients (surgery, chemo + ?)
**Margin -** 2cm margin requirement **Anterior resection is precluded if** there is sphincter involvement or if the margin would involve the sphincter --\> The surgery of choice would be an APER (Abdomino-Perineal Resection) **TME -** total mesenteric excision. This involves the dissection of mesorectal fat + lymph nodes **Obstructive rectal tumours --\>** Defunctioning Loop Colostomy( Differs from colonic tumours where aim can be to resect and anastamose immediately if safe) **Rectal cancer can be treated with radiotherapy as it is extraperitoneal**
52
Management of Weber Fractures
Weber Fractures - malleolar fractures A - Below syndesmosis. Full Weight Bearing with ankle boot B - At level of syndesmosis. If stable (Unimalleolar) then ankle boot and mobilise. If unstable - Below knee plaster and no weight bearing for six weeks C - Above level of syndesmosis - Inherently unstable. Fixation, syndesmosis reconstruction with screws.
53
By what mechanism does ECF Volume depletion cause Metabolic Alkalosis
Losing significant bodily fluid through vomiting or diuretics results in a loss of Na+ + Cl- This leads to RAAS activation --\> aldosterone causes increased ENaC channels so more Sodium crosses from lumen into cells. Luminal K+ channels upregulated so potassium is lost to the lumen. Na+K+ATPase at interstitial side of cells is upregulated ---\> K+ is moved into the cell whereas Na+ is moved into interstitium. These three transporter changes lead to an increase loss of K+ to the collecting duct lumen and a preservation of Na+ Loss of K+ Leads to K+/H+ Buffering. K+ moves from cells into ECF in exchange for H+ -----:\> **Alkalosis**
54
**Brisk duodenal ulcer** Treatment
Brisk Duodenal Ulcer - Usually posteriorly sited and invading the gastroduodenal artery. Duodenal ulcer pain occurs several hours after eating. Treatment: Resuscitate Surgery - Laparotomy --\> Duodenotomy. Underrunning the ulcer by biting above and below ulceration point which will also occlude artery. Transverse closure
55
**Gastric Ulcer Surgical Management** **Antral ulcer** **Lesser Curve Ulcer**
Antral Ulcer- Partial Gastrectomy (If underunning doesn't work) Lesser curve ulcer - Partial Gastectomy / Under Running (Usually involves Left gastric artery) Some patients will need a total gastrectomy.
56
Size threshold for surgical repair of rotator cuff tear
\> 2 cm
57
**Where do the rotator cuff muscles attach**
Lesser Tuberosity - Subscapularis (subscapualr fossa) Greater Tuberosity - Supraspinatus (supraspinatus fossa), Infraspinatus (infraspinatus fossa), Teres Minor (lateral border)
58
**Neer Classification**
For proximal humeral fractures Described as 2,3 or 4 part depending on how many fragments - Greater Tuberosity - LEsser Tuberosity - ARticular Surface - SHaft
59
Supports for the uteres
Central Perineal Tendon - Perineal body. This is essential. Extends between vagina and anus. Round ligament - Uterine horns --\> through inguinal canal --\> mons pubis Transverse Cervical/ Cardinal Ligament - Attaches to obutrator fascia on pelvc side wall Uterosacral ligament - from uterus to anterior aspect of sacrum
60
**what is the broad ligament**
The broad ligament is a fold of peritoneum that envelops the uterus, ovaries and fallopian tubes. It folds over the fundus of the uterus forming the: **Mesometrium (covers the uterus)** **Mesovarium (covers the ovaries)** **Mesosalpinx (covers the fallopian tubes)**
61
**investigating large bowel obstruction**
First line: DRE, AXR, ?Rigid Sigmoidoscopy Then: CT- AP If inconclusive --\> Gastrograffin follow through
62
**Impending signs of perf in LBO**
Caecal \>12 cm Competent Ileocaecal valve Caecal tenderness
63
Managing local anaesthetic toxicity Max Doses
Intralipid: Bolus- 1.5 ml/kg over 1 minute Infusion - 0.25 ml/kg/minute If prilocaine is used then administere methylene blue 1st dose - neat/ 2nd dose w/adrenaline **Lignocaine -** 3 mg/kg. 7 mg/kg Bupivicaine - 2 mg/kg 2 mg/kg Prilocaine - 6 mg/kg 9 mg/kg **Prilocaine**
64
**Procedures for lymphodoema**
Homans - skin preserving procedure ( where skin is good). Skin flaps formed and then underlying subcutaneous tissue excised Charles - skin and underlying subcut tissue all excised down to fascia. split skin grafts are applied. used for poor overlying skin condition. Lymphonvenous anastamosis - exclusively for proximal obstruction + good distal lymphatics. Anastamoses between distal lymph structure and deep vein.
65
Why is tissue black in gangrene?
Hb degeneration and deposition of iron sulphide
66
**Best test for vWD**
Bleeding Time (factor VIII may also be low) vWD can be Autosomal Dominant: Type I - Quantitative deficiency of vWF Type 2 - Qualitative impariment of synthesis of vWF Autosomal Recessive Type 3 - Absolute deficiency in vWF
67
**Causes of diarrhoea** Campylobacter Shigella Salmonella EColi Yersinia Vibrio Cholera
Camp - Most common. Gram Negative Rod (comma shaped). Reactive Arthritis, GBS Shigella - Gram negative bacilli. Dysentry Salmonella - Gram negative, facultative anaerobe, enterobactericiae. ECOLI - ETEC, EIEC, EHEC Yersinia Enterocolitica - Gram Negative coccobacilli. Terminal Ileitis - mimic Crohn's/ Appendicitis. Cholera - Gram Negative Rods. Watery diarrhoea
68
Sartorius
Supplied by Anterior Femoral Nerve (L2-L3) ASIS --\> proximal tibia Flexes - knee and hip Medially rotates femur.
69
Which Coag factors to the following influence: Heparin Warfarin Liver Disease Disseminated Intravascular Coagulation
**Heparin -** 2,9, 10, 11 **Warfin -** 2, 7, 9 , 10 **Liver disease -** 1, 2 , 5 , 7, ,9, 10, 11 **DIC -** 1, 2, 5, 8, 11
70
**Lymphatic drainage of male genitalia** To the: Inguinal Nodes Iliac Nodes **Where is the external sphincter (urethral) in males?** **Where does sperm enter urethra?**
**Deep Inguinal Nodes -** Spongy urethra, Glans Penis **Iliac Nodes -** membranous urethra, prostatic urethra **External Sphincter surrounds -** Membranous urethra (membranous urethra extends from prostate --\> perineal membrane) **Where does sperm enter urethra -** prostatic urethra
71
**Colonic Polyp Risk (colonoscopy)** **Low** **Medium High**
Low: 1-2 adenomas - \< 1 cm **No follow Up** Medium: 3-4 adenomas/ 1 adenoma \>1cm - **3 year follow up** High: 5 or more Adenomas/ 3 adenomas + 1 being \>1cm - **1 year follow up**
72
**Infective organism:** **Large bowel ulcers and necrosis**
EnteroInvasive E Coli
73
**Structures passing through the Parotid Gland**
Facial Nerve (superficial) Retromandibular Vein ( next most superficial) External Carotid Artery (deep to the vein) Auriculotemporal nerve
74
**What is diaphragm disease**
Due to long term NSAID use Small bowel becomes seperated into compartments where there is thickened circular mucosal abd submucosal membranes ---\> focal areas of small callibre lumens --\> frequent small bowel obstructions
75
**Which nerve is responsible for flexing thumb**
Solely median nerve Forearm - flexor pollicis longus Hand - flexor pollicis brevis
76
**What drain is used surgically after CBD exploration?**
T Tube: Latex. This is to induce a fibrotic reaction so a tract will form
77
**What is sibson's fascia?**
Fascia overlying the apex of both lungs C7-first rib (inbetween thoracic cage + parietal pleura)
78
**Right Lung Anatomy**
Three Lobes - Seperated by oblique and transverse fissure Azygous Vein - Just above hilum Superior vena cava + inominate vein - Groove is further above hilum Oesophagus - Behind Hilum Inominate Artarey - Near apex IVC groove- near lower part of the oesophageal groove
79
**Left Lung Anatomy**
Two lobes - Seperated by oblique fissure Groove for aortic arch - Above HIlum Groove for subclavian artery - Furhter Above hilum Groove for descendign aorta - behind hilum Oesophagus - lower part of the lung
80
JVP Deflections a c v x y
**Ascents** **a** - trial contraction c - ventri**c**ular contration v - atrial **v**enous filling **Descents** x - atrial relaxation y - ventricular filling / atrial emptying
81
**Superficial peroneal nerve** **Deep peroneal nerve**
Arise when common peroneal bifurcates between fibula and peroneus longus **Superficial -** peroneal longus and brevis **Cutaneous -** lateral lower third of leg and most of dorsum of foot (except lateral foot which is supplied by sural nerve and medial leg which is supplied by saphenous nervee) **Deep -** Tibilaris anterior, peroneus tertius, Extensor hallucis longus, extensor digitorum longus + brevis Terminates into **medial** and **lateral branches** **C****utaneous supply** - first web space
82
**Psoas Major and Minor**
Major - originates from lumbar vertebrae and attaches onto lesser trochanter Innervated - Anterior Rami of L1-L3 Minor - High lumbar origin and attaches to pubic crest (superior) Innevated - anterior rami of L1
83
**Blood tests for carcinoid tumours** **Urine Tests**
Chromogranin A Neuron Specific Enolase Substance P Gastrin Urine- 5 HIAA 5 Hdyroxytriptamine
84
**Tumour Genetics Colorectal** FAP HNPCC Cowden Peutz Jehger
FAP - APC mutations (TS Gene) HNPCC - MSH2, MLH1, PMS2 + GTBP (Amsterdam Criteria, DNA Mismatch repair Genes) Cowden - PTEN (Autosomal Dominant) Peutz Jehger - LKB1, STK11
85
86
**Divisions of the laryngeal cavity**
Vestibule - Superior to vestibular folds Ventricle - between vestibular folds and vocal cord Infraglottic - vocal cord to cricoid cartilage
87
**Muscles of the larynx (6/7)**
Posterior Cricoarytenoid - Abduct vocal fold Lateral Cricoarytenoid - Adduct Vocal fold Thyroarytenoid - Relax Vocal Fold Transverse + Oblique Arytenoids - Close Rima Glottidis Vocalis - Relaxes posterior part of vocal ligament and tenses anterior part of vocal ligament Cricothyroid - Tenses vocal ligament (Innervated by External Laryngeal Nerve)
88
**Vascular Supply of Larynx** **Lymph Drainage**
Superior and Inferior Laryngeal Arteries ( branches of superior and inferior thyroid arteries ) Superior and inferior Laryngeal veins drain into the Superior and Middle thyroid veins Respectively **Lymph Drainage of Larynx:** Supraglottic - Upper Deep Cervical Subglottic - Prelaryngeal + Pretracheal + Inferior Deep Cervical Vocal Cords don't have lymphatic drainage
89
**Femoral Triangle:** **Borders** **Structures**
**Borders**: Lateral - Femoral Vein Medial - Lacunar Ligament Anterior - Inguinal Ligament Posterior - Pectineal ligament **Structures**: Lymphatic Vessels, Cloquet's Lymph Node
90
**Desmoid Tumours** Associated with which GI Disorder What Structures do they arise from
**Associated with FAP (APC Tumour Suppressor Gene Mutations)** **They are proliferations of myofibroblasts arising from Musculoaponeurotic Structures**
91
**Male Genital injuries** i) Meatal Haematoma, Perineal Haematoma, Urinary Retention ii) High Riding Prostate, Perineal Oedema/ Haematoma, Pelvic Fracture iii) haematuria, suprapubic pain, inability to retrieve all irrigation through bladder
i) Bulbar Urethral Rupture ii) Membranous Urethral Rupture iii) Bladder Rupture For Urethral Injury: Ix - Ascending Urethrogram Mx - Surgical Suprapubic Catheter For Bladder Injury: Intraperitoneal - Laparotomy Extraperitoneal - Conservative
92
**Diaphragmatic Apertures:** **T12** **T10** **T8**
T12 - Aortic T10 - Oesophageal Oesophagus + Vagus Trunks T8 - Caval IVC +Right Phrenic Nerve
93
**Classifying Open Fractures** **What should be empirically done**
Gustillo and Anderson Classification System: **I** Low Energy wound \<1cm **II** - \>1cm wound with modeate soft tissue damage **IIIA -** High Energy (\>1cm) + Adequate tissue coverage **IIIB** - High Energy (\>1cm) + Inadequate soft tissue coverage **IIIC -** High Energy (\>1cm) + Arterial Injury **Empirically -** Tetanus Prophylaxis + Broad Spectrum Abx + Check neurovascular status + Debride and lavage
94
**p53 germline mutations --\> Cancer\<45**
**Li-Fraumeni Syndrome** p53 is a tumour suppressor gene Individuals develop sarcoma \<45 years old
95
**Gardner Syndrome**
**APC Gene Mutations** Multiple Polyposis Supernumeray Teeth Jaw + Skull Osteoma Hypertrophic Retinal Pigment Thyroid Cancer Cutaneous Lesions
96
**Which hormones are reduced in stress response?**
Insulin Oestrogen Testosterone
97
**Superior Vena Cava** **Formation** **What joins before entering right atrium?** **Sites of collateralisation in SVCO**
Forms from - Right and left Inominate veins ( these respectively form from Internal + Subclavian Veins) **Azygous vein forms before entring right atrium - Forms from union of ascending lumbar veins and subcostal veins.** **Collateralisation -** Primarily Azygous Internal Thoracic Vein - originates at superior epigastric vein and terminates in brachiocephalic vein Long thoracic Vein - drains from serratus anterior and pectoralis major to axillary vein. A connection between LTV and superficial epigastric vein (the thoracoepigastric vein) alows shunting
98
**Median Nerve** Which branches supply what
**Median nerve supplies:** Flexor Carpi Radialis, Palmaris Longus, Flexor Digitorum Superficialis **Anterior interosseus nerve**: (branch given off in upper forearm) (Deep forearm muscles) Lateral part of flexor digitorom profondus, flexor pollicus longus, pronator quadratus **Palmar Cutaneous Branch:** (given off in the forearm) s Sensation to thenar eminence **Recurrent Muscular Branch:** (hand branch given off just after flexor retinaculum) Opponens Pollicis, Abductor Pollicis Brevis, Flexor Pollicis Brevis) **Digital Cutaneous branch:** (hand branch given off just after flexor retinaculum) Lateral lumbricals,
99
**Blood Supply to CBD**
Hepatic Artery and branches of Gastroduodenal artery
100
**Hepatobiliary Triangle**
Medially - Common Bile Duct Inferiorly - Cystic Duct Superiorly - Inferior Lobe of liver **Contents Cystic Artery**
101
**Workup in oesophogeal Ca**
Staging CT Diagnostic Laparascopy --\> look for peritoneal disease PET CT **If none of these are positive then proceed to consider for surgery** Distal Ca --\> Ivor Lewis Two stage Proximal --\> Mckeown three stage
102
**Blood supply to rectum** **What is the extraperitoenal rectum Surrounded by?** **Fascia surrounding rectum**
Three arteries **Superior -** From IMA **Middle -** From Internal Iliac **Inferior -** From Internal Pudendal (branch of internal iliac) **Extraperitoneal rectum is surrounded by -** Mesorectal fat containing lymph nodes (hence need for total mesorectal excision) **Anterior rectal fascia - Denonvillers** **Posterior rectal Fascia - Waldeyers**
103
Innervation of the infrahyoid strap muscles
**Sternohyoid - Ansa cervicalis** **Sternothyroid - Ansa Cervicalis** **Thyrohyoid - C1 Spinal nerve (through hypoglossal nerve)** **Omohyoid - Superior belly - Superior root of ansa cervicalis - C1)** **Inferior Belly - Ansa Cervicalis** **Ansa cervicalis - Cervical plexus exists in carotid triangle** **- Two roots -** Superior Originates from C1, Inferior orginiates from C2+C3
104
**Ligamentous Anatomy of the Ankle Joint** **Medial -** **Lateral -** 3 components **Between Tibia and Fibula -** 4 components
**Medial** - Deltoid Ligament **Lateral** - Lateral ligament complex: 3 components Anteriotalofibular ligament Calcaneofibular ligament Posteriotalofibular ligament **Syndesmosis -** ligament complex between distal fibula and tibia - 4 components Anterior-inferior tibiofibular ligament Transverse tibiofibular ligament Interosseus membrane Posterior-Inferior tibiofibular ligament
105
X Ray indicators of Ankle Syndesmotic Injury
Decreased tibiofibular overlap Lateral/Medial joint clear space Lateral Talar Shift
106
**principles for operating in acute cholecystitis**
\<48 hours surgery is a good idea \>5 days - surgery is best left deferred to 3 months to allow inflammation to settle
107
**Mucinous colorectal cancer at young age** **Family history**
Likely to be Lynch Syndrome or HNPCC
108
**Immunlogics and their uses** Bevacizumab Trastazumab Imatinib Basiliximab Cetuximab
Bevacizumab **(anti-VEGF)** - Colorectal, Renal, Glioblastoma Trastazumab **(anti-HER2) -** Breast Imatinib (**TK inhibitor) -** GIST, CML Basiliximab (**IL2 R) -** Post renal transplant Cetuximab (**Epidermal Growth Factor Receptor inhibitor)** - Colorectal
109
**Fistulae** **When is it safe to conersvatively manage?** **Drug therapy for high output fistula** **Contraindication to probing perianal fistulae** **How to delinieate fistula tract?**
**Conservative management -** In the absence of IBD or distal obstruction **Octreotide** si used to reduce pancreatic secretions in the context of high output fistulae **Perianal fistulae** should not be probed in teh context of **acute inlammation** Fistula anatomy can be delineated using CT and barium studies
110
**Management of Liver Metastases**
Patients with good physiological reserve - Chemotherapy + Surgical Resection 5 Year Survival can be as good as 20% With poor physiological reserve - Radiofrequency ablation
111
**Glucocorticoids** At a cellular level - MOA Metabolic effects Regulatory Effects
**They bind to intracellular receptors -**these migrate to the nucleus acting as transcription factors **Metabolic:** Decrease uptuake and utilisation of glucose --\> increase gluconeogenesis Increase protein catabolism Potentiate lipolysis **Regulatory:** Negative Feedback on hypothalamus Prevent vasodilation and fluid loss from vessels Increase osteoclastic activity/ Decrease osteoblastic activity Decrease inflammation (Decrease B/T Cell clonal expansion)
112
**Hip Joint** Vascular Supply Gold Standard Investigation for fractures if plain films are inconclusive Internal Fixation, Hemiarthroplasty or THR
**Vascular Supply** - Medial and lateral femoral circumflex arteries **(branches of profunda femoris)** which go onto anastamosis and enter the joint capsule **at the posterior neck base.** Ligament of teres provides small blood supply **Imaging -** MRI is gold standard if plain radiographs aren't good enough however in practice CT is sought **internal fixation -** Young displaced/undisplaced, Elderly undisplaced **Hemiarthroplasty -** Displaced **and** poor baseline mobility/ cognitive impariment/ medically unfit **THR -** Displaced **and** good baseline mobility/ no cognitive impairment/ medically fit
113
**Colonic cancers with threatened resection margin mangement** **Rectal cancers with threatened resection margin management**
**Colonic cancers** with threatened resection margin mangement - **Primary Resection** **Rectal cancers** with threatened resection margin management - **Long course chemotherapy.**
114
Nerve most commonly injured during superficial parotidectomy
**Greater Auricular Nerve** **-** ascending branch fo cervical plexus arising from 2nd and 3rd cervical nerves - Ascends sternoclediomastoideus coming underneath the platysma muscle - **Branches into anterior and posterior overly the parotid.**
115
**Pancreatic Adenocarcinoma** **RFs** **Most common Location** **Ix** **Mx**
RFs- Smoking, Diabetes, Adenoma, FAP **Most commonly in the head of pancreas** Ix - USS, CT Scan **IF on CT** it is deemed unresectable **no further staging** **IF on CT** it is deemed **resectable --\>** PET/CT, ERCP/MRI, Staging Laparoscopy (peritoneal disease) Mx - **Head -** Whipple's **Body/Tail -** Distal Pancreatectomy **Adjuvant Chemotherapy** **ERCP**
116
**Contents of the popliteal fossa**
**Most Medial** Artery Vein Tibial Nerve Common Peroneal Nerve Soemtimes sural nerve **Most Lateral**
117
**What level do the following branches come off the aorta?** Coeliac Superior Mesenteric Inferior Mesenteric
Coeliac - T12 Superior Mesenteric - L1 Inferior Mesenteric - L3
118
**What level do the following branches come off the aorta?** Inferior phrenic Lumbar Median Sacral
Inferior phrenic - T12 Lumbar - L1-L4 Median Sacral - L4
119
**What level do the following branches come off of the aorta?** Middle suprarenal Renal Gonadal Common Iliac
Middle suprarenal - L1 Renal - L1-L2 Gonadal - L2 Common Iliac - L4
120
**Colles Fracture**
Dinner fork deformity Transverse distal radius fracture Dorsal displacement and angulation
121
**Smiths Fracture**
(reverse colles') Distal Radius transverse fracture Volar angulation of fragment
122
**Bennett's Fracture**
Intraarticular fracture of 1st MCP Triangular fragment at ulnar base of metacarpal
123
**Monteggia Fracture**
**Ulnar fracture** Proximal radioulnar joint dislocation
124
**Galeazzi Fracture**
Radial shaft fracture Dislocation of distal radioulnar joint
125
**Barton's Fracture**
Distal Radius fracture (Colles or Smiths) **with** radiocarpal dislocation
126
**what nerve is responsible for otalgia post-tonsillar surgery**
Glossopharyngeal nerve
127
**What is the most common site of intessusception paediatric?**
Ileo-caecal - This is usually maanged by fluroscopically guided air insufflation Ileo-ileal is less common but needs a laparotomy
128
**Origins of gluteal arteries** **Gluteal Nerves**
Inferior gluteal artery - **anterior trunk of internal iliac artery** Superior gluteal artery - **posterior trunk of internal iliac artery** **Superior Gluteal Nerve -** L4, L5, S1 **Inferior Gluteal Nerve -** L5, S1, S2
129
**Epigastric Pain and Audible Bruit**
Median Arcuate Ligament Syndrome: The median arcuate ligament of the diaphragm compresses the coelic trunk and coeliac ganglia. Pain realted to meals.
130
Aortic Aneurysm - Iliac Involvement
Open Repair
131
**What is the level of the transpyloric plane** **Contents of the transpyloric plane (13)**
**Transpyloric plane - L1!** Pylorus of the stomach Left Kidney Hilum + Right Kidney Hilum (Note right lower than left) Gall bladder fundus Pancreatic Neck Duodenojejunal Fixture Superior Mesenteric Artery Portal Vein Left and right Colic Flexure Roof of the transverse mesocolon 2nd part of the duodenum Upper Part of conus medullaris Spleen
132
**Functional Renal Imaging** **DMSA** **Diethylene-triamine-penta-acetic acid** **MAG 3 Renogram** **Micturating Cystourethrogram** **Intravenous Urography** **PET/CT**
**DMSA** - Localises in the renal cortes. --\> Cortical defects, scarring, Ectopic or aborrhent kidneys. **Diethylene-triamine-penta-acetic acid DTPA -** Glomerular Filtration Agent. Provides useful information about eGFR **MAG 3 Renogram -** Secreted by tubular cells so good for imaging kidney in patients with existing renal impairment. **Micturating Cystourethrogram -** Assessment of bladder reflux. Bladder filled with contrast via catheter **Intravenous Urography -** Good for renal function, and detection of urinar tract calculi **PET/CT -** Staging
133
**Statistical Tests:** **T Test** **Fishers Exact Test** **Spearmans Rank Test** **Mann Whitney U Test** **Bonferroni Test**
**T Test -** normal distribution **Fishers Exact Test -** determines the signfificance of athe deviation from null hypothesis. **Spearmans Rank Test -** significant relationship between two sets of data **Mann Whitney U Test -** nonparametric test of the null hypothesis that sample from one group is equally likely to be lesser than or greather than sample from another group **Bonferroni Test -** counteracts problems of multiple comparisons
134
**Brachial PLexus Questions** In which fascia are the upper 3 rami of the brachial plexus contained within pre-axillary artery? Which part of the axillary artery does the plexus surround? where are the cords formed? Which divisions form which cords?
They are contained within the pre-vertebral fascia The plexus surrounds the second aprt of the axillary artery Cords are formed in the Axilla **Cords:** **Posterior Cord -** Dorsal divsions of C5- C8 (Upper, Middle and half of Lower Trunk) **Medial Cord-** Ventral divisions of C8-T1 (Lower Trunk) **Lateral Cord -** Ventral Divisions of C5-C7 (Upper and middle trunk)
135
**Brachial Plexus Questions:** **What are the terminal nerves of the brachial plexus (not branches)?** **What forms the:** Long Thoracic Nerve Dorsal Scapular Nerve Upper Subscapular Nerve Thoracodorsal Nerve Lower Subscapular Nerve Axillary Nerve Suprascapular Nerve Nerve to subclavius Lateral pectoral Nerve Musculocutaneous Nerve Medial Cutaneous nerve of the arm Medial cutaneous nerve of the forearm Ulnar Nerve
**Terminal Nerves are - Radial Nerve ( From Posterior Cord)** **Median nerve (Lateral and Medial Cord)** **Derived from:** **Roots:** Posterior- Long Thoracic Nerve- C5-C7 Dorsal Scapular Nerve - C5 Anterior - Nerve to Subclavius - C5-C6 **Trunks:** Suprascapular Nerve - Upper Trunk **Cords :** Upper Subscapular Nerve - Posterior Cord Thoracodorsal Nerve - Posterior Cord Lower Subscapular Nerve - Posterior Cord Axillary Nerve - Posterior Cord Lateral pectoral Nerve - Medial and Lateral Cord Musculocutaneous Nerve - Lateral Cord Medial Cutaneous nerve of the arm - Medial Cord Medial cutaneous nerve of the forearm - Medial Cord Ulnar Nerve - Medial Cord
136
**Describe Subclavian Steal syndrome**
Stenosis/ Occlusion of subclavian artery, proximal to the origin of the veryebral artery.
137
**What surgery for Conjugated hyperbilirubinaemia in baby?**
Biliary atresia: **Kasai procedure -** Roux-en-Y portojejunostomy if this fails ---\> Liver transplant
138
**Phrenic Nerve Topography**
C3- C5 Left: Deep to prevertebral fascia across scalenus anterior Crosses anterior to part 1 of subclavian artery Posterior to Subclavian vein and Internal Thoracic ---\> enters the thorax Lateral to left subclavian, aortic arch and left ventricle. Anterior to lung hilum and pierces diaphragm Right: Deep to prevertebral fascia across sclaneus anterior Croses anterior to 2nd part of subclavian artery Posterior to Subclavian vein and Internal Thoracic ---\> enters the thorax Travels anterior to right vagus and laterally to SVC passes over R atrium and exits through the caval opening at T8 of diaphragm
139
Cancer arising of the kidney due to long term inflammation?
Squamous Cell Carcinoma
140
**Scalenus Anatomy** **Innervation** **Which structures pass through**
**Scalenus Anterior Medius and Posterior** **-**Anterior and medius both insert onto first rib Posterior inserts onto second rib **Innervation:** Spinal Nerves C4-C6 **Brachial Plexus and subclavian artery both pass inbetween scalenus anterior and medius**
141
Why use bupivicaine post-operatively over lidocaine?
It has a much longer duration of action than lignocaine and therefore can provide longlasting wound-site analgaesia
142
**What would be the LA of choice in regional block?**
Prilocaine - this is much less cardiotoxic
143
**Basilic Vein Path** **Cephalic Vein Path**
**Basilic** - is **Medial**. Originates from dorsla venous network ---\> passes most of the way superficially. Anterior to the antecubital fossa ---\> joins the cephalic vein the the median cubital vein Pierces the biceps fascia Ascending medially it becomes the axillary vein **Cephalic -** is **Lateral** Ascends lateralyl from the dorsal venous network. Travels lateral to antecubital fossa. Into Deltopectoral triangle inbetween pectoralis and deltoid Empties into axillary vein
144
**Prostate Disease-Which lobe** **BPH** **Carcinoma** **Prostate** **Arterial Supply** **Venous Drainage** **Lymph Drainage**
BPH - Median Lobe Carcinoma - Posterior Lobe **Arterial Supply -** Inferior Vesical Artery (branch of internal iliac) **Venous Drainage -** Prostatic Venous PLexus ( to paravertebral veins) **Lymph Drainage -** internal iliac (+sacral)
145
When are hepatocellular adenomas resected?
\>5 cm due to risk of rupture or In males due to high risk of malignancy
146
**Coeliac Artery** Branches of coeliac artery Level of coeliac artery from aorta
**Level - T12** **Branches:** **Left Gastric -** Oesophageal and stomach branches **Common Hepatic -** Proper hepatic (branches into left and right hepatic- right giving off cystic artery), Right Gastric, Gastroduodenal (branches into r. gastroepiploic + superior pancreticoduodenal) **Splenic Artery -** Dorsal pancreatic, Short Gastric, Left gastro-omental, Greater Pancreatic
147
**Anatomy of the foot arches**
Longitudinal: Posteriorly supported by calcaneum Laterally- passes over cuboid bone and lateral two metatarsal bones Medially - head of talus (summit) between the subtentaculum tali and navicular bone. Anterior pillar is navicular, cuneiforms and medial three metatarsals. Transverse: Between Anterior tarsus and posterior metatarsus.
148
**What constitutes:** Sub Talar Joint
Facet on lower surface of talus body + Posterior facet on the upper surface of calcaneus Synovial
149
**What constitutes:** **Talocalcaneonavicular joint**
Anteroinferiorly the navicular bone communicates with the subtentaculum tali of the calcaneus (Posteroinfeiorly) to provide a place for communication of the Talus to sit.
150
**Hip Joint** **Intracapsular ligamnets** **Extra Capsular Ligaments** **Majority of blood supply to head of femur?**
Intrcapsular - Transverse Ligament Ligament of Teres Extracapsular: Ilofemoral Pubofemoral Ischofemoral **Medial and lateral circumflex femoral arteries (both branches of profunda femoris/ inferior gluteal artery)**
151
**Which strucures pass through** **Inferior Sciatic Foramen** **Superior Sciatic Foramen** **Both**
**They are divided by sacrospinous ligament.** **Lesser** (Anterior - ischium tuberosity, Superior - Sacrospinous ligament + spine of ischium, Posterior - sacrotuberous ligament) Obturator Internus Tendon **Greater (**Anterior - greater sciatic notch of ilium, Posterior- sacrotuberous ligament, Inferior - sacrospinous ligament + ischial spine, superior - anterior sacroiliac ligament) **Nerves**- sciatic, Superior (above piriformis) and inferior gluteal nerves, posterior femoral cutaneous nerve, nerve to quadratus femoris, nerve to obturator internus) **Arteries + Veins -** Superior Gluteal A +V, Inferior Gluteal A+V, ) **Both** Pudendal Nerve Internal Pudendal A+V Nerve to obturator internus
152
**Deep Perineal Pouch** Anatomical Location Contents
Anatomical location: Bounded inferiorly by inferior fascia of urogenital diaphragm and superiorly by superior fascia of urogenital diaphragm Contents: Urethral sphincter Transversus Perinei Nerves - Dorsal nerve of penis, perineal nerve branches Vessels - Urethral artery, deep artery of penis, dorsal artery of penis, origin of artery to bulb of penis
153
**Left Common Carotid Anatomy** **Thorax -** **Neck -**
Originates from arch of aorta - **Thorax -** In contact with trachea, recurrent laryngeal nerve and oesophagus Left brachiocephalic vein passes anteriorly in front of it **Neck -** Runs beneath SCM and enters anterior triangle In carotid sheath with - vagus nerve, and (lateral to ) internal jugular vein vertebral artery and thoracic duct lie posterior to the artery in the neck **Bifurcate** at level of C3 vertebrae/ upper border of throid cartilage **Right Common Carotid -** **Same except** : Branch of brachiocephalic trunk. No thoracic duct on the right side
154
**Sulphur Granules and Gram Positive Organisms -** Histology
Actinomycosis - Forms multiple sinuses The sulphur granules (round or oval basophilic masses)
155
**Within what time should an open fracture be internally fixated?**
72 hours
156
**Malignant Fibrous Histiocytoma** Four SubTypes Treatment
**Subtypes**: Storiform - Pleomorphic Myxoid Giant Cell Inflammatory **Treatment:** Surgical resection + pseudocapsule resection Chemotherapy
157
**Large pathological deposit in bone** **?management**
Surgical Fixation - to prevent fractures
158
**When do you consider surgery for polyps?**
Incomplete excision of malignant polyp (endoscopically) Malignant sessile polyp Malginant peduncalated polyp with submucosal invasion Polyops with poorly differentiated carcinoma Familial polyposis syndromes
159
**Growth Plate Fracture Classifications**
**SALTER** **I S** traight through growth plate **II A** bove and through growth plate * *III B** elow and through growth plate * *IV T** hrough metaphysis epiphysis + growth plate **V E** Everyything (crush injury)
160
**Which space does LP go?**
Subarachnoid
161
**Popliteal Fossa** **Borders** **Contents**
Borders: Lateral: Biceps femoris, Lateral head of gastroc and plantaris Medial - Semimembranosis and semitendinosis, medial head of gastroc Floor - Popliteus, Femur Roof - Superficial and deep fascia Contents: Vascular: Popliteal artery, Popliteal Vein, Short Saphenous Vein Nerves: posterior cutaneous nerve of thigh, tibial nerve, genicular branch of of obturator nerve
162
**Which vein is related to:** **Sural Nerve** **Saphenous Nerve**
Sural nerve: Short Saphenous Vein: Lateral side of foot. Passes inferio-lateral to the lateral malleolus. Enters popliteal fossa between gastroc heads. Saphenous Nerve: Long saphenous Vein: Medial side of foot. Passes anterior to medial malleolus. Traverses the medial posterior femoral epicondyle. Migrates laterally on anterior thigh.
163
**Common extracolonic manifestation of FAP**
Duodenal and gastric polyps
164
**Paediatric Neck Masses:** Cyst above the hyoid Cyst below the hyoid Anterior to SCM at the angle of mandible Posterior to SCM
Cyst above the hyoid - **dermoid -** heterogenous appearane Cyst below the hyoid - **Thyrogossal cyst -** thin walled and anechoic Anterior to SCM at the angle of mandible - **branchial cyst -** failure of obliteration of usualy 2nd arch. anechoic. can become infected Posterior to SCM - **cystic hygroma -** can be closely aassocated with surrounding structures. lymphatic malformation
165
**Paediatric fluid management**
100 ml/kg/day - first 10 kg 50 ml/kg/day - second 10 kg 20 ml/kg/day - subsequent kgs Neonates: First day- 50-60 ml /kg/day Second day - 70 - 80 ml/ kg / day Third day - 80 - 100 ml /kg / day fourth day - 100-120 ml/kg/day 5-8 days - 120-150 ml /kg / day
166
**Oxygen Dissociation Curve** **Causes of Right Shift** **Causes of left shift**
Right shift - Reduced affinity for oxygen --\> increased oxygen delivery **High** High H+ (Acidosis) High temp High 2-3 DPG CO2 Left shift - higher affinity for oxygen--\> lower oxygen delivery **Low** Low H+ (alkalosis Low Temp Low 2-3 DPG **DPG - is high in conditions where there is reduced oxygen delivery to tissues - High Altitude, Low Hb**
167
**Tymus Histology** **ARterial Supply** **Venous Drainage**
Encapsulated Lobular Structure originating from III and IV pharyngeal arches Cortex - Lymphocytes Medulla - Concentric epithelial cells with keratinsed centre Arterial Supply: Internal mammary artery (or pericardiophrenic arteries) Venous Supply: Left Brachiocephalic vein
168
Scaphoid abdomen
Abdomen sucked inwards: Think diaphragmatic hernia in newborn
169
**management of diverticular stricture + LBO**
Laparatomy and hartmann's Dilating - contraindicated Stenting - often not useful
170
**Wound healing - Predominant Cell Types** **Inflammation** **Regeneration** **Remodelling (Contraction)**
**Inflammation** Neutrophils. Early phase (first week) **Regeneration** Fibroblasts. (8 weeks) Microvascularisation **Remodelling (Contraction)** Differentiated fibroblasts. Microvessels regress so the scar looks pale.
171
Exposure to vinyl chloride
Hepatic Angiosarcoma
172
**Ileostomy effluent**
Na - 126 mmol/ L K+ - 22 mmol/L
173
**Contents of Cavernous Sinus**
O TOM CAT Ophthalmic nerve Trochlear Nerve Ophthalmic nerve (V1) Maxillary nerve (V2) Internal Carotid Artery Abducens Nerve
174
**Foramen of Munro** **Magendie** **Lushka**
**Munro:** Lateral Ventircles into Third ventricle **lushka:** Anteromedial apertures of the fourth ventricle **magendie:** Posteriorinferor of the fourth ventricle
175
**what provides sensory innervation to posterior thigh**
Posterior Cutaneous Nerve of thigh: Direct branch of Sacral PLexus
176
**SMA** **Origin from Aorta** **Branches**
L1 Inferior Pancreatico-duodenal artery Jejunal and Ileal Arcades **ileocolic** **right colic** **middle colic**
177
**Musculocutaneous Nerve** **Origin?** **Action?**
Origin: Branch of Lateral Cord of brachial plexus Action: Continues into forearm as **lateral cutaneous nerve of forearm** Innervates - coracobrachialis, brachialis, biceps brachii
178
**Structures passing through foramen ovale** **Through which bone is the foramen**
Sphenoid bone **OVALE** O - tic ganglion V - V3 Mandibular nerve A - accessory meningeal artery L - lesser petrosal nerve E- missary veins
179
**Location and content of following skull foramina** **Ovale**
**Ovale** (sphenoid) Otic Ganglion, V3, Accessory Meningeal Art., Lessor Petrosal Nerve, Emissary Veins
180
**Spinosum**
**Spinosum** (Sphenoid) Middle Meningeal Artery, Meningeal branch of mandibular nerve
181
**Rotundum**
**Rotundum** (Sphenoid) V2
182
**Foramen Lacerum - Location and contents**
**Lacerum** (Sphenoid) ICA, Nerve + Art. of pterygoid canal
183
**Jugular Foramen - Location and Contents**
**Jugular** (temporal) Inf. Petrosal Sinus, IX, X, XI, Sigmoid Sinus (becomes Int. jug), Meningeal branches of occipital and ascend. pharyngeal art.
184
**Foramen Magnum -** location and contents
**Foramen Magnum** (occipitaL) Medulla oblongata, Ant. + Post. Spinal Art. , Vert. Art
185
**Stylomastoid Foramen - Location and contents**
**Stylomastoid** **Foramen** (Temporal) Stylomastoid Artery, CNVII
186
Superior Orbital Fissure - Location and contents
**Superior Orbital Fissure (Sphenoid)** III, IX, V1, Recurrent meningeal artery, VI, Superior Ophthalmic Vein
187
**Lymph Drainage of Auricle (Ear)** **Lateral upper Half** **Cranial Superior half** **Lower half and lobule**
**Lateral upper Half -** Superficial parotid **Cranial Superior half -** deep cervical + Mastoid **Lower half and lobule -** Superficial cervical
188
**parotid malignancy:** perineural skip lesions Most common derived from secretory portion
perineural skip lesions **- Adenoid Cystic Carcinoma** 35% 5 year survival. Tendency for visceral spread Most common- **Mucoepidermoid carcinoma** Don't usually metastasise derived from secretory portion - **Adenocarcinoma**
189
**Pharyngeal Pouch is between?**
Diverticulum between cricopharyngeus and thyropharyngeus
190
**Oesophagus:** **Arterial** **Venous** **Lymphatic** Beginning and termination Location of strictures
**Upper Third:** Arterial **- Inferior Thyroid Artery** Venous - **inferior thyroid vein** lymph - **Deep cervical** **Middle Third:** Arterial - **Aortic Branches** Venous - **Azygous** Lymph - **Mediastinal** **Lower Third:** Arterial - **Left Gastric** venous - **left gastric** lymph - **gastric** **Begins - C6, Ends , T11** **Strictures:** Cricoid, Aortic Arch, Left Bronchus, Oesophageal Hiatus
191
**Urine Calcium-Creatinine Clearance in :** **Primary Hyperparathyroidism** **Familial Hypocalciuric Hypercalcaemia**
**Primary Hyperparathyroidism (Kidneys try to remove calcium)** \>0.01 **Familial Hypocalciuric Hypercalcaemia (Autosomal Dominant loss of calcium sensing --\> High PTH despite high calcium, normal calcium resorption despite high calcium)** \<0.01
192
**Drug Causes of Gynaecomasti**
Digoxin, Cimetidine, Dopamine receptor antagonists, Methyldopa, Cannabis, Oestrogens, Anabolic Steroids, **Spiro**, Finasteride Heroin Isoniazid etc. rare causes
193
**Branches of External Carotid Artery**
MASS FLOP Maxillary Ascending Pharyngeal Superior Thyroid Artery Superficial temporal artery Facial Artery Lingual artery Occipital Artery Posterior Auricular Artery
194
**Branches of subclavian artery**
VIT C&D Verterbral Internal thoracic Thyrocervical Trunk ( Inferior Thyroid, Suprascapular, Transverse Cervical) Costocervical Trunk (superficial intercostal + deep cervical) Dorsal Scapular (joins with transverse cervical) becoming Transverse Cervical --\> Superficial and Deep descending branches
195
**What is in cryoprecipitate**
VIII Fibrinogen XIII vWF
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What is anular ligament? What articulates with the capitulum? What articulates with trochloea?
**Anular ligament-** Proximally located liagment between ulnar and radius to permit supination and pronation movements at the proximal radioulnar joint **Capitulum -** Distal end of humerus. This articulates with the concave groove on the radius head **Trochlea -** articulates with ulnar.
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Occluded posterior nasal airway in newborns
**choanal atresia** Cyanotic episodes when feeding
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Bilateral pulmonary infiltrates CVP Reading \<18 mmHg \>18 mmHg
\<18 mmHg = ARDS (fat embolus, sepsis, acute pancreatitis, trauma, lung injury, head injury) Low tidal volume ventilation, diuresis \>18mmHg = Pulmonary Oedema
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**Margins for melanoma resection**
Breslow thickness score: 1mm - 1cm margin 1-2mm - 1-2cm margin 3-4mm - 2-3 cm margin \>4mm - 3 cm margin Lymph resection + isolated limb chemotherapy infusion as adjuncts
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**Malignancy Arising as a result of chronic oedema**
Lymphangiosarcoma - these are agressive lesions
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What happens to the rectal stump
202
**Ventilation** **What are the three cerebral areas responsible for ventilation and what do they respond to?** **Any non-cerebral areas involved?**
**Medulla** **Oblongata** This responds to increased interstitial H+ to increase ventilation (to blow off CO2). The **Apneustic** Centre in pons instigates inspiration whereas the **Pneumotaxic** Centre, also in the pons, inhibits inspiration. **Peripheral chemoreceptors** are in the carotids and arch of aorta --\> these respond to arterial pO2, pCO2 and H+
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**Ulnar Nerve** Origin Innervates? (10) Relationship to ulnar artery Topography
**Origin** - C8 T1, derived from **medial** cord of plexus **Innervates**: **Muscular Branch -** Flexor Carpi Ulnaris+ Flexor Digitorum Profondus (medial) **Deep Branch-** Flexor Digiti Minimi Abductor Digiti Minimi Opponens Digiti Minimi Adductor pollicis Interossei Muscles Medial 2 lumbricals (III and IV) Flexor Pollicis Brevis Palmaris brevis **Also -** **Dorsal** cutaneous branch, **palmar** cutaneous branch, **Superficial** (medial digits) branch Medial to the ulnar artery **Topography:** Medial side of upper arm then passes posterior to medial epicondyle Pierces two heads of flexor carpi ulnaris and travels deep to this near the ulna bone
204
**where does the chorda tympani arise and from what?**
Inside the facial canal from the facial nerve - so not effected in facial nerve lesion at the parotid
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**Facial Nerve Topography** order of canals through whence it travels? 3 branches within facial canal? 2 branches immediately after exits the temporal bone? branches of facial nerve at parotid gland?
**I)** It enters the internal adutiory meatus travles through the facial canal and then exits via the stylomastoid foramen **ii) Greater petrosal nerve, nerve to stapedius and chorda tympani** **iii)** Posterior auricular nerve, branch to posterior belly of digastric +stylohyoid muscle **iv)** temporal, zygomatic, buccalis, marginal mandibular nerve, cervical
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**Sensory innervation of the mouth** Inferior Molars Inferior Canines and incisors Gingiva and supportive structures Upper teeth
Generally - **upper teeth** by the **maxillary nerve** **and lower teeth** by the **mandibular nerve** **Lower Teeth:** Molars - inferior alveolar nerve Canines and incisors - Incisive branch of inferior alveolar gingiva and supportive - lingual nerve **Upper teeth:** Superior alveolar plexus: Molars - Posterior Superior alveolar nerve (SAN) premolars - middle SAN front teeth - anterior SAN
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**Giant Cells** most commonly arise from?
Macrophages - Giant cells are collections of distinct cell types
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**Any distant metastases in oesophageal/gastric ca?**
Not for surgery and chemotherapy reserved for young and fit
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**Below which blood pressure does renal autoregulation of flow fail?**
\<80 systolic blood pressure
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WHat is a: Bankart Lesion Hill Sachs Lesion
**Bankart Lesion -** avulsion of anterior glenoid labrum **Hill Sachs Lesion -** chondral impaction on posteriosuperior humeral head from contact with glenoid rim
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**What stimulates insulin release(6)**
Glucose Amino Acids Secretin/CCK/Gastrin Vagal Cholinergic Action Fatty Acids Beta **adrenergic** drugs (blockers block release)
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**Ansa Cervicalis** Origin What fascia is it posterior to What does it innervate
Origin - C1 (superior root), C2-3 (inferior root) Posterior to - Pretracheal fascia Innervates - sternohyoid, sternothyroid, omohyoid
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**Anal Sphincter** Smooth and striated components Nervous supply
**Smooth muscle-** upper two thirds of anal canal **Striated muscle** - superficial to smooth muscle but surrounds the entire canal **Nerve supply-** inferior rectal branch of pudendal nerve **and** perineal nerve
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**Radial Nerve** Origin Innervates Branches
Origin: **Posterior** Cord of brachial plexus, C5 to T1 **Innervates:** **main branch -**Triceps, Anconeus, Brachioradialis, Extensor Carpi Radialis **posterior interossues nerve** (deep branch)- Supernator, extensor carpi ulnaris, extensor digitorum, extensor digitorum, extensor indicis, extensor digiti minimi, extensor pollicis longus and brevis, abductor pollicis longus **sensory -**
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**Axilla** **aBoundries** **Contents**
Boundaries: Anterior - pec major, Posterior - lat dorsi Medial - serratus anterior + chest wall Lateral - Humeral Head **Contents:** Long Thoracic Nerve Thoracodorsal Trunk Axillary Vein Intercostobrachial nerves Lymphatics
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**Lymphatic drainage** **Inferior to the dentate line** **Superior to the dentate line**
**Inferior to the dentate line -** Inguinal lymph nodes **Superior to the dentate line** - Mesorectal
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**Which genetic condition do you see plexiform neurofibromas?**
NF Type I - can cause accelerated growth of limb
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**5 investigations for incidental adrenal lesions** **Beyond which size lesion shoudl you worry?**
Morning and midnight plasma cortisol Dex Suppression Test 24 Hour urinary cortisol 24 hour urinary catecholamines Serum potassium, aldosterone and renin \>4cm is 25% risk of malignancy
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**Absence Vas Deferens?**
Cystic Fibrosis
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**Inguinal Canal** Borders Contents Where do the testes lymph drain
Borders: Anterior - Aponeurosis of external Oblique Posterior - Transversalis Fascia Floor - Ingiinal Ligament and Lacunar Ligament (medially) Roof - Arching fibres of the transversus abdominus and internal oblique Superficial ring - External Oblqieu Deep ring - Transversalis Fascia **Contents** **3 Fascia -** External Spermatic Fascia (External oblique), Cremasteric Fascia (internal oblique), Internal Spermatic Fascia (transversalis fascia) **3 Arteries -** Testicular Artery, Artery to vas, Cremasteric Artery **2 Veins -** Testicular Vein (Left into left renal, right into IVC), Pampiniform Plexus, **3 Others -** Vas Deferens, Lymphatics **3 Nerves -** Genitofemoral, Ilioinguinal, Iliohypogastric **Where do testes drain to? -** para aortic
221
What is the inverse of odds ratio?
Number needed to treat
222
Smooth abdominal swelling in child - no worrying features. Mobile
Mesenteric cyst - usually need to be surgically removed - can undergo torsion rupture
223
**hyposplenism blood film (4)**
Howell - Jolly body Target Cells Pappenheimer cells Irregularly contracted erythroyctes
224
**What do you incise for median sternotomy?**
Interclavicular ligament + interclavicular fossa Sternum with bone saw pericardium
225
**Masounieve Fracture**
Medial malleoulus Fracture Spiral fracture of proximal 1/3 fibula dorsal tibiofibular syndesmosis
226
**key anatomical deformities of tallipes equinovarus (5)**
Adductes and inverted calcaneus Wedged shaped calcaneal articular surface +head of talus tibio-talar plantar flexion medial talar neck inclination medially displaced navicular and cuboid
227
**Parathyroid neoplasms:** Most common cause? Indications for surgery in primary hyperparathyroidism?
Commonly - adenoma Indication for surgery: Ca++ \>1 above normal Calciuria \>400 mg/day Decreased creatinine clearance Life threatening hypercalcaeima Nephrolithiasis \<50 years age Neuromuscular symptoms Reduction in bone mineral density
228
**what regulates ion exchange in the salivary glands?**
Aldosterone
229
Management of traumatic pneumothorax and why?
Chest drain - Usually in context of traumatic pneumothorax there is damage to lung parenchyma = High chance of tension pneumo development
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**Describe the trendelenberg procedure**
Head tild and legs abducted Oblique incision medial to artery Ligation of tributaries Saphenofemoral junction double ligated Stripping of vein proximal (knee or upper calf)
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**Muscles attaching to the greater trochanter of femur** **POGGGO**
Piriformis Obturator Internus Gemelli, Gluteus medius, Gluteus Minimus Obturator Externus
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**What is the blood supply to the omentum**
Left Gastroeipoloic Artery (branch of splenic) Right Gastroepiploic Artery (branch of gastroduodenal)
233
**What is common liver fluke?** **Disease?**
Fasciola Hepatica **Disease:** **Two -** Acute - fever, abdo pain, rash, and hepatomegaly Chronic - Obstructive jaundice due to worm maturing in bile ducts
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**What enters the IVC and at what level?**
Inferiorly: I LIKE TO RISE SO HIGH Common Iliacs fuse at **L5** Lumbar veins **L1-L5** Right Gonodal vein (Left generally drains into Left renal vein) **L2** Suprarenal veins and renal veins **L1** Hepatic vein, inferior phrenic vein **T8 -** also caval hiatus (diaphragmatic)
235
**Body Fluid Volumes**
60% of a person is fluid **Intracellular - 60%** **Extracellular - 40%** **Plasma - 5%** **Interstitial - 24%** **Transcellular - 3%**
236
**Treatments for meconium ileus**
PR Contrast (diagnostic and therapeutic) N-Acetyl Cysteine Enemas
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**Nerve fibres:** **A alpha** **A beta** **B fibres** **C Fibres**
**A alpha** - Motor proprioception **A beta -** touch and pressure **A delta -** myelinated pain fibres **B fibres -** autonomic **C Fibres -** unmyelinated c fibres
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**Red streaks and tender mass on limb?**
Lymphadenitis
239
**External urethral sphincter supply**
Supplied by pudendal branches (S2-S4) Pudendal nerve also supplies - external anal sphincter + cutaneous innervation to the perineum
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241
**Structures posterior to the medial malleolus** **Anterior to medial malleolus** **Posterior to lateral malleolus:**
**Posterior to medial malleolus:** Tibialis Posterior Tendon Flexor Digitorum Longus Posterior Tibial Artery Tibial Nerve Hallucis Longus **Anterior to medial malleolus:** tibialis anterior tendon great saphenous vein **Posterior to lateral malleolus:** short saphenous vein, sural nerve (superficial) peroneus longus tendon, peroneus brevis tendon (deep)
242
**Lichen Sclerosus - pathophysiology** **Treatment**
Pathophysiology - Abnormal fibroblast proliferation Treatment: 1 - High dose corticosteroid 2 - Calcineurin inhibitors (Tacrolimus) 3- Retinoids, methotrexate, steroid injections, photopherapy, cyclophosphamide
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**Which sarcomas metastasise to lymphatics**
SCARE Synovical Sarcoma Clear Cell Sarcoma Angiosarcoma Rhabdomyosarcoma Epitheloid sarcoma
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Which drug prevents conversion of plasminogen to plasmin?
Tranexamic Acid
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Which clotting factors are particularly heat sensitive?
Factor V Factor VIII Hence FFP is frozen
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**Branches of the external carotid artery**
**Some anatomists like freaking out poor medical students** Superior Thyroid Aryery Ascending Pharyngeal Linguial Artery Facial Artery Occipital Artery Posterior Auricular Maxillary Artery Superior Temporal Artery
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**Staging for perthe's disease**
**catterall staging system** **I -** Clinical + Histological **II -** Sclerosis +/- cystic changes **III -** Loss of integrity of femoral head **IV -** Loss of acetabular integrity
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**Muscular Compartments of lower limb**
**Anterior Compartment** innervated by - Deep Peroneal Nerve Tibialis Anterior, Peroneus Tertius, Extensor Hallucis longus, Extensor Digitorum Longus **Peroneal Compartment** innervated by - Superficial peroneal nerve peroneus longus, peroneus brevis **Superficial Posterior compartment** innervated by - tibial nerve Gastrocnemius, Soleus **Deep posterior compartment** innervated by - tibial nerve flexor digitorum longus, flexor hallucis longus, tibialis posterior
249
**What is laplace's law?**
hollow circumferential organs: total wall tension depends on: i) circumference of wall ii) Thickness of wall iii) wall tension
250
**Adrenal Anatomy** **Arterial Supply** **Venous drainage** **Adrenal Relations**
Adrenal Arteries: **Superior** from **inferior phrenic artery** **middle** from **aorta** **inferior** from **renal artery** Adrenal Veins: **Left** - into renal vein (as for testicular vein) **right -** directly into IVC **Adrenal Relations:** **Right: Posterior -** Diaphragm**, Anterior -** Hepatorenal pouch **+** bare area of liver**, Inferior -** Kidney**, Medial -** IVC **Left: Posterior -** diaphragm crus **, Inferior -** kidney**, Anterior -** pancreas and splenic vessels
251
**What is a hadfield's procedure**
Total Duct Excision (For mammary duct ectasia)
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**Anterior and posterior relations of carotid sheath**
**Anterior:** Hypoglossal Nerve Ansa Cervicalis Omohyoid Muscle Only on right - Recurrent laryngeal nerve **Posterior:** C6 - Cervical Sympathetic Chain C7 - vertebral artery, thoracic duct Inferior thyroid artery
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**Why might gastritis cause anaemia?** **Which form of gastritis is foveolar hyperplasia associated with?** **factors increasing gastric acid production?** **Factors decreasing Gastric Acid production?** **(where are these produced)**
**Anaemia:** Loss of parietal cells - Loss of intrinsic factor production - loss of B12 absorption - macrocytic anaemia **Foveolar hyperplasia -** Reflux gastritis --\> due to bile reflux into the stomach **factors increasing gastric acid production?** Vagal stimulation, histamine, gastrin **Factors decreasing Gastric Acid production?** Cholecystokinin, secretin, somatostatin Gastrin - G cells in antrum of stomach CCK - I Cells in small intestine Secretin - S Cells in small intestine Somatostatin - D Cells in pancreas/stomach Vasoactive intestinal peptide - small intestine/ pancreas
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**Difference between gastroschisis and omphalocele?**
Gastroschisis - Right of umbilicus Bowel outside of abdominal wall not covered by peritoneum Omphalocele (Exomphalos) - Through umbilicus. The protruding GI organs are covered by peritoneum
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**The lifecycle and treatment of :** Ascariasis Enterobius Vermicularis Strongyloidiasis Anclyostoma Duodenale Giardiasis Cryptosporidium
**Life Cycle** **Treatment** Ascariasis (roundworm) Ingestion -\> lung migration -\> cough and autodigest Mebendazole Anclyostoma Duodenale (Hookworm) Skin penetration -\> Lung migration -\> cough and autodigest -\> Hooked to small intestine luminal wall Mebendazole Strongyloides Skin penetration -\> lung migration -\> Cough and autoingest Mebendazole Enterobius Vermicularis Oral ingestion. Pruritis Ani. Mebendazole Giardiasis Ingestion of cysts Metronidazole Cryptosporidium Ingestion of cysts Metronidazole
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**Dose of heparin for:** ## Footnote **Vascular Bypasses** **Cardiopulmonary bypasses**
**Vascular Bypasses** 3000 units prior to cross clamping **Cardiopulmonary bypasses** 30,000 units priot to initiating bypass
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**Amputation** Removal of femoral condyles Retention of patella
Gritti Stokes Amputation Patella is swung posteriorly to cover distal femoral surface
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Gross Thyroid Anatomy ## Footnote **Vascular supply of thyroid** **Arterial** **Venous**
Apex of thyroid cartilage to 4/th/5th tracheal ring. R + L lobe with isthmus in the middle. **Arterial:** **Superior Thyroid** (first branch of external carotid) **Inferior thyroid** (from thryocervical trunk - subclavian artery) **Venous SUpply:** **Superior** and **Middle** thyroid vein - Into Internal Jugular Vein **Inferior** thyroid vein - into brachiocephalic veins
259
**Flexor tendons in carpal tunnel (9)**
4 FDP 4 FDS 1 Flexor Pollicis Longus
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**Types of electrosurgical current**
Blend - Less power than cutting. Alternates between cutting and coagulating Coagulate - Modulated current with high peak voltage. Cut - High power and current. Little thermal damage Fulgurate - Electrode not in contact with tissue. Low amplitude/ high voltage. Local superifical tissue destruction Dessicate - Electrode in contact with tissue. Low current/ high voltage. Loss of cellular water but not protein
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262
**Descending Thoracic Aorta** **Relations** **branches**
**Relations** Anterior - Left Lung root, Pericardium, Oesophagus, Diaphragm Posterior - Vertebral Column, Azygos Vein, Right - Hemi Azygos Veins, Thoracic Duct Left - Left Pleura and lung **Branches** Bronchial Artery, Mediastinal Artery, Posterior Intercostal ARteries, Oesophageal Arteries
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**Sympathetic Ganglia Locations** **Cervical** **Thoracic** **Lumbar** **Damage to which causes:** **Horner Syndrome** **Ejaculatory problems**
Cervical: Superior - C2,C3 Middle - C6 Stellate - C7 Thoracic ganglia are segmentally arrange Lumbar ganglia - descend posterior to median arcuate ligament of diaphragm and lie anterior to vertebrae and medial to psoas **Horner Syndrome - T1** **Ejaculatory problems -** **L1**
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**Relations of the caecum**
Posterior: Psoas, Gonadal Vessels, Ureter, Iliacus, Femoral nerve, genitofemoral nerve, Anterior: Greater Omentum
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**Thoracic Duct** Where does it enter thorax What is it continuation of What does it drain What importantly doesnt it drain Relation to oesopahgus
**Thoracic Duct:** Enters the thorax alongisde the oesophagus at the oesophageal hiatus of **T12** It is a continuation of the **cisterna chlyii** The lymphatics of the **left** head and neck drain **directly** into the thoracic duct, which itself drains into the **left** **brachiochephalic** **vein**. the **right** side of the head and neck drain into the **right** lymphatic duct **which drains** into the **mediastinal duct** and then into the **right brachiocephalic vein** It lies **posterior to the oesphagus** then passing to the **left at T5**
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**Actions of PTH**
Bone - Osteoblasts binding --\> inreased RANKL expression --\> Activation of osteoclasts ---\> increase resorption Kidney - Resorption of calcium and mangesium from DCT. Decreased resorption of phosphate GI - PTH increases Vit D activation --\> increased GI calcium absorption
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**Localised oesophageal tumours with no mets:** **SCC vs ADenocarcinoma**
For SCC trial of chemoradithoerapy can be curative whereas for Adenocarcinoma surgery is the only curative option
268
**WHy does H Pylori cause increased acid production?** **How can the duodenum have ulcers with H Pylori infection**
Urease enzyme hyrdrolyzes urea --\> Ammonia Ammonia causes antral G cells to produce more gastrin H Pylori itself causes ulcers due to chronic inflammatory changes. The duodenum comes to have these changes when it becoems colonsed. This occurs when the duodenal mucosa undergoes metaplasia as a result of excess acid --\> then allowing the H Pylori organisms to colonise the metaplastic tissue
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**ureter anatomy** Releation to iliac vessels and uterine artery Blood Supply
Releation to iliac vessels and uterine artery: Anterior to iliac bifurcation, posterior to uterine artery Blood Supply: Segmental: Renal, aortic, gonadal, common iliac, internal iliac
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**Features of MEN conditions**
271
Digastric nervous supply
Anterior - Mylohyoid Nerve Posterior - Facial Nerve
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**Which artery do the following branch from?** **Superior Cerebellar Artery** **Anterior Inferior Cerebellar Artery** **Posterior inferior cerebellar artery**
**Basilar Artery** Superior Cerebellar Artery Anterior Inferior Cerebellar Artery **Vertebral ARtery** Posterior inferior cerebellar artery
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**Branches of:** **Vertebral Artery** **Basilar Artery** **Internal Carotid Artery**
**Vertebral Artery** Anterior Spinal ARtery, Posterior Spinal ARtery, Posterior Inferior Cerebellar Artery **Basilar Artery** Superior Cerebellar Artery, Anterior Inferior cerebellar Artery, Pontine ARteries, Labyrynthine ARtery, Posterior cerebral artery **Internal Carotid Artery** PComm,Anterior Cerebral Artery (AComm exists between htese two), Middle Cerebral ARtery, Anterior Choroidal ARtery
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**Seminoma Subtypes (4)**
Classical (lmyphocyte infiltrate in stroma) Spermatocytic (tumour cells remember spermatocytes) Anaplastic Syncitiotrophoblast Giant Cells
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Attachments of the extensor retinaculum of the wrist
Medial - pisiform and triquetral Lateral - Radius
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Management of Low Grade DCIS vs LCIS
DCIS - WLE LCIS - Monitoring
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**Drug Causes of hyper uricaemia (8)**
Ciclosporin Alcohol Nicotinic Acids Thiazides Loop Diuretics Ethambutol Aspirin Pyrazinimide
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**Which muscles form the pes anserinus?** **Where is it?**
Sartorius Gracilis Semintendinosis It is on the anteromedial proximal extermitiy of the tibia
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**Quadrangular Space** **Borders** **Contents**
Borders: Lateral - humerus, Superior - subscapularis + teres minor, Inferior - teres major, Medial - tricpes long head Content: Axillary Nerve Posterior Circumflex ARtery
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**Branches of the axillary artery** **Relations of axillary artery**
**First** **Part**: Superior Thoracic ARtery Above Pec Minor Axillary artery + vein enclosed within the axillary sheath. Anterior - Clavipectoral fascia, Posterior - Serratus Anterior, Long thora nerve, first intercostal space. **Second** **Part**: Thoraco-acromial and lateral thoracic arteries Behind Pec minor Here the cords relate to the artery true to their names. **Third** **Part**: Subscapular, anterior circ and posterior circ arteries Inferior to pec minor Posterior - subscapularis, lat dorsi, teres major
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**Relations of brachiocephalic artery** **Where does it bifurcate**
Right brachiocephalic vein + vagus - **laterally** trachea - **posteromedially** inferior thyroid vein - **anteriorly** **Bifurcates at level of sternoclavicular joint**
282
What is para- amino hippuric acid (PAH) used to measure?
Renal Plasma Flow
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**What does sistrunks procedure involve**
Thyroglossal Cysts: Involves resection of: cyst, track, central hyoid portion + wedge of tongue muscle behind hyoid resection
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**TB or Sarcoid?** Asteroid Bodies Extensive Necrosis
Asteroid Bodies - Sarcoidosis Extensive Necrosis - Tuberculosis
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**When do you offer long course neoadjuvant chemoradiotherapy for rectal cancer??**
T4 tumours
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**Where are the following valves located in CXR?** **Tricuspid** **Mitral** **AOrtic**
**Tricuspid -** 5th ICS on right **Mitral -** 4th ICS on left **AOrtic -** 3rd ICS on right
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**lymph drainage of female internal genitalia** **Ovaries** **Uterine Fundus** **Uterine Body** **Cervix**
**Ovaries -** Para aortic **Uterine Fundus -** Para aortic + Inguinal **Uterine Body -** Iliac Lymph nodes **Cervix -** Presacral, Internal Iliac and External Iliac
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**Management of Axillary Vein Thrombosis**
Acute - Catheter GUided tPA Heparin / Warfarin if chronic
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**Hepatocellular Carcinoma** Staging System? Treatment?
**Barcelona Clinical Liver Classification** 0 - \<2 cm - resection A - \>3 cm / \<3 nodules. radiofrequency ablation or transplant B - \>3 nodules. Transarterial chemoembolisation C - Advanced tumours/ Portal vein invasion. Sorafenib D - supportive
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Air fluid level in chest in baby
Bronchogenic Cyst This should be CTd Thorascopic Resection at 6 weeks
291
**Subclavian Artery Branches**
Vertebral Artery Internal Thoracic Artery Thyrocervical Trunk Costalcervical Trunk Dorsal Scapular Artery
292
**Cellular characteristic of Hurthle Cell Tumours**
OXyphil Cells Scanty Thyroid Colloid This is a form of follicular
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**Where do the following genitalia structures arise/drain?** **Artery of Vas Deferens** **Creamsteric Artery** **Pampinofrm Plexus**
**Artery of Vas Deferens -** Inferior Vesical Artery (from internal iliac artery) **Creamsteric Artery -** Inferior Epigastric Artery (from external iliac artery) **Pampinofrm Plexus -** Venous Plexus (into testicular vein - left into renal vein, right directly into IVC)
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Best and worst prognostically Hodgkin's Lymphoma's? Alll Hodgkin's Lymphoma's
**Best - Lymphocyte Rich** **Worst - Lymphocyte Deplete** **Other Subtypes:** Nodular Sclerosing Mixed Cellularity Nodular Lymphocyte - predominant
295
**Which fascia contains the base of the penis?**
Bucks Fascia
296
**Erb's Vs Klumpke's Palsy**
**Klumpke's: (C7-T1)** Claw Hand (MCP extension/ IP flexion) Loss of sensation over medial forearm/hand Horner's Syndrome Loss of wrist flexors **Erb's Palsy: (C5-C6)** Waiter's Tip Extended Elbow, Pronates Forearm Adducted and internally rotated shoulder Impairment to - wrist extensors, Elbow flexor, external rotators
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**Muscles innervated by buccal branch of CN VII (6)**
**Buccal (Buccal membrane - mouth)** Zygomaticus Minor Risorius Buccinator Levator Anguli Oris ORbicularis Nasalis
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**Common Carotid:** **Pulse palpable at -** **Bifurcates at -**
Palpable at C6 against the transverse process of vertebra Bifurcates at C4
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**Merkel Cell Tumour** Histologically Related to? Treatment
Histologically : Sheets + nodules of hyperchromatic epithelial cells with ++ mitosis and apoptosis Lymphovascular invasion Related to sunlight damaged skin Treatment: Surgical excision (1 cm margin) + SLNB if \>10mm lesion Adjuvant radiotherapy
300
**Which RLN has a more superiorly situated course?**
The **RIGHT** Remeber that this one arches around the subclavian posteriorly, whereas the left branches more distally and branches-\>arches around the anterior aspect of the arch of the aorta
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**Arterial Supply to the nose**
Sphenopalatine Artery (Maxillary ARtery ) Greater Palatine Artery (Maxillary Artery) Facial Artery (Anteriorly) Most Bleeding from Keisselbach's Plexus
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**Goodsalls Rule**
Anterior fistulae - internal opening opposite the external opening Posterior fistulae - curved track that passes toward the midline (6 o clock)
303
**Constirctions of oesophagus (ABCD)**
Arch of Aorta Left Main Bronchus Cricoid Cartilage Diaphragmatic Hiatus
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**Cryotherapy shouldn't be used for..** **Radiotherapy shouldn't be used for..** **in context of cutaneous malignancy**
Cryotherapy - shouldnt be used for deep lesions Radiotherapy - shouldnt be used for lesions in regions which are prone to radionecrosis (nose)
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**in DIC which components of clotting are depleted fastest**
V, VIII and Platelets
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Signet Ring Cell proliferation in stomach
Linitis Plastica - Stomach Doesnt Distent on OGD
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**The oesophagus doesn't have which mucosal layer?**
Serosa
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309
**Effects of Adrenaline**
**Alpha -** Peripheral Vasoconstriction Insulin inhibition Glycogenolysis in liver/muscle and glycolysis in muscle **Beta -** 1 - Cardiac chronotrope + inotrope, increased renin secretion 2 - Skeletal muscle vasodilation + coronary artery vasodilation. Bronchodilation Glucagon secretion, ACTH secretion, Lipolysis in adipose tissue
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**Muscles Supplied by the Ansa Cervicalis**
**Ghost Thought Someone Stupid Shot Irene** Geniohyoid Thyrohyoid Superior Omohyoid Sternothyroid Sternohyoid Inferior Omohyoid
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**Common peroneal nerve** **Roots** **Where does it bifurcate**
**Roots -** L4 - S2 **Where does it bifurcate** Bifurcates at neck of fibula after descending posterior to biceps femoris into lateral part of popliteal fossa
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**Retromandibular Vein** **What are its tributaries** **Where does it go**
Arises from the joining of the maxillary vein and superficial temporal vein Descends through the parotid gland
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**Associations with anal fissure**
STI IBD Leukaemia TB
314
**DTPA vs MAG3**
DTPA - good for assessment of GFR MAG3 - good for assessment of renal function in patients with known impairment
315
**Which structures lie in the free border of lesser omentum?**
Hepatic Artery, CBD and Portal Vein
316
**Contrainidications to surgical resection in lung malignancy?**
SVCO FEV1 \<1.5L Malignant Pleural Effusion Vocal Cord Paralysis Tumor near hilum
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contents of porta hepatis
Common hepatic Duct Hepatic Artery Portal Vein Nerve Fibres Lymphatic Drainage
318
Calculating NNT?
1/(Control rate - Experimental Rate)
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**Digastric Muscle innervation**
Anterior Belly - Mylohoid Nerve Posterior Belly - Facial Nerve
320
**Sessile Serated Polyps** Best management?
These are more commonly found on the right Should be removed
321
**Displaced Anatomical Humeral Head Fractures require...**
Hemiarthroplasty - Due to high risk of AVN
322
**Lesions giving early para-aortic lymphadenopathy**
Ovarian Testicular Uterine Fundus
323
**Contents of superior mediastinum**
Arch of aorta SVC Brachiocephalic Veins Thoracic Duct Trachea Oesophagus Thymus Vagus Nerve Left RLN Phrenic Nerve
324
**Contents of middle mediastinum**
Aortic Root Pericardium Heart Arch of azygos vein Main Bronchi
325
**Contents of :** **Anterior Mediastinum** **Posterior Mediastinum**
Anterior: Thymic remnants, LNs, Fat Posterior: Oesophagus, Thoracic Aorta, Azygos Vein, Thoracic Duct, Vagus Nerve, Sympathetic Nerve Trunks, Splanchnic Nerves
326
**Rockall Score** **WHen?** **Components?**
Following Endoscopy for UGI haemorrhage Components: A Age B BP C Co-morbidities D Diagnosis E vidence of bleeding
327
**Kocher Criteria for Septic Arthritis**
**WIFE** WCC \>12 I - inability to weight bear Fever ESR \>40
328
**Lateral Hip rotators** **Nerve supplies**
Piriformis - Ventral Rami of S1/S2 Obturator Internus - Nerve to obturator internus Superior Gemellus - Nerve to obturator internus Inferior Gemellus - Nerve to quadrator Femoris Quadrator Femoris - Nerve to quadrator Femoris
329
330
331
**Drug Treatment for Colonic Pseudoobstruction**
Neostigmine
332
**Basal Cell Carcinoma Margin for Excision**
5 mm
333
**Neck Surface Anatomy**
C3 - Hyoid C4 - Thyroid Cartilage Notch C6 - Cricoid
334
**What are the attachments of the spleen?**
Ileorenal Ligament (to the posterior abdominal wall) Gastrosplenic ligament ( to the stomach)
335
**Hydrocele treatment in :** **adults** **children**
Adults - lords/ jabourlay's - plication/otomy of sac + ligation of PPV Children - ligations of PPV
336
**management for biliary leak post lap chole**
ERCP + Stent
337
**Biliary Decompression as an adjunct to curative pancreatic surgery**
ERCP + Stent Do not surgically bypass them
338
**Features of von hippel-lindau syndrome**
Cerebellar hameangiomas Retinal Haemangiomas renal cysts phaeochromocytomas extra-renal cysts: epididymal, pancreatic, hepatic endolymphatic sac
339
Enterocutaneous fistula at the umbilicus due to....
Failure of obliteration of omphalpmesenteric duct
340
**Indications for surgery in hyperparathyroidism**
Age \>50 Serum Calcium \> 1 above mornal hypercalciuria \>400 mg/day Creatinine clearance \<30% Renal stones Neuromuscular Symptoms Reduction in bone density
341
**Pink Serous Fluid discharge after laparatomy?**
Think about early dehiscence
342
**Management of sudden full dehiscence**
Analgaesia, IV fluid, IV abx Cover wound with saline gauze Return to theatre STAT
343
**Which nerve wraps around the middle meningeal artery\>**
Auriculotemporal nerve - branch of the mandibular nerve.
344
Mass posterior to angle of mandible
Parotid Gland Tumour
345
**Double Stranded DNA Virus** **Single Stranded RNA Virus**
DS DNA - HEP B SS RNA - HEPC + HIV
346
**Where is bucks fascia**
Bucks fascia is continuous with the external spermatic fascia into the penis
347
**Musculocutaneous Nerve** Roots Innervates Topography
Roots - C5-C& Innervates - Biceps, Brachialis, Corachobrachialis topography - Arises from lateral cord (C5-C7) of brachial plexus. Travels between the heads of the biceps muscles. Then inbetween biceps and brachialis. Terminates in forearm as the lateral cutaneous nerve of the arm
348
**Does UC affect the anal canal**
No It starts from the rectum. Spares the anal canal and the transition zone
349
CXR features of aortic disruption
Trachea deviated to the right Left Bronchus depression Most disruption is in proximal descending aorta
350
**Greater Sciatic Foramen** **Boundaries** **Contents**
Boundaries: Anterolateral - Greater sciatic notch of ilum Posteriomedial - sacrotuberous ligament Inferior - Sacrospinous ligament Superior - Anterior sacroiliac ligament Contents: **Nerve:** **Sciatic** nerve **Superior** + **inferior** gluteal nerves **Pudendal** Nerve Posteror Femoral Cutaneous Nerve Nerve to quadrator femoris Nerve to obturator internus Vessels: **Superior + Inferior Gluteal Vessels** **Internal pudendal vessels**
351
**Which breast cancer is more common in women breast feeding or who are pregnant**
Inflammatory Carcinoma - THese are more aggressive
352
**Popliteal pulse disappears when leg fully extended**
Popliteal fossa entrapment syndrome main differential here would be adductor canal compression syndrome
353
**Bariatric Surgery Selection Criteria**
\>40 BMI \>35 + Other significant disease that can be helped with wieght loss 6 months of other measures have not helped Fit for surgery Commit to follow up + specialist management
354
**BEst way to assess for upper airway compression?**
Flow Volume Loop
355
**Anaerobic Organism complicating difficult operations\>**
Bacteroides Fragilis - Gram Neg, Anaerobe, Rod Shaped Involved in majority of peritoneal infections
356
**Branches of the external iliac artery**
Inferior Epigastric Artery (Anastamoses with superior epigastric artery, which is a branch of internal thoracic artery) Deep Circumflex Iliac ARtery Terminates as Femoral Artery
357
358
**Obstructive Jaundice in the context of HIV patient likely to be due to...**
Sclerosing Cholangitis 2o to - CMV, Cryptosproidium or Microsporidia
359
**Branches of the posterior cord of the brachial plexus**
Subscapular Nerves ( Subscapularis) T - horacodorsal A - xillary R - adial
360
**What does serotonin do to vessels?**
Intact vessels - Vasodilation Damaged vessels/tissue - vasoconstriction
361
**Four drugs commonly associated with parotid enlargement**
Thiouracil Isoprenaline Phenylbutazone Oestrogen Contraceptic pills
362
**What is a:** **Pilon Fracture**
Pilon Fracture - Distal Tibia including the articular surface with ankle Tilloux Fracture - Child fracture involving the distal tibial epiphysis. Is an avulsion fracture due to the anterior tibiofibular ligament pull in an abduction injury.
363
**Which Cord of the brachial plexus do the following nerves come from?** **Axillary Nerve** **Medial Pectoral Nerve** **Lateral Pectoral Nerve** **Medial Brachial Cutaneous Nerve** **Medial Antebrachial Cutaneous Nerve** **Subscapular Nerves** **Thoracodorsal nerve**
Posterior Cord (C5-T1) Posterior divisions of all trunks) - Subscapular Nerves, Thoracodorsal Nerve, Axillary Nerve Lateral Cord (C5-C7 Ventral Divisions of Upper and Middle Trunk) Lateral Pectoral Nerve Medial Cord (C8-T1 ventral Divisions of lower trunk) Medial Pectoral Nerve Medial Brachial Cutaneous Nerve Medial ANtebrachial Cutaneous Nerve
364
**where are most anal fissures?**
Posterior midline (90%) Anterior midline (10%)
365
**Nephroblastoma vs Nueroblastoma distinguishing features**
**nephroblastoma:** (Wilm's) Arise from the kidney. Associated with Hypertension No Calcification on CT **Neuroblastoma:** Arise from neural crest (often from adrenal Gland) Calcification on CT
366
**Ventricular Tachycardia** Drug therapies
Amiodarone Lidocaine Procainamidwe **NOT VERAPAMIL**
367
**Drug cause of SIADH**
Carbamezapine, SSRIs, Sulfonylureas, TCAs, vincristine, cyclophosphamide
368
**Sites of ectopic testes**
Superficial Inguinal Pouch Base of Penis Femoral Triangle Perineum
369
Multifocal high grade dysplasia of oesophagus Treatment?
**Resection** In old patients might be a place for local treatment - Endoscopic resection, photodynamic therapy
370
**Strangulation risk** **Femoral** **Indirect Inguinal** **Direct Inguinal**
**Femoral - 40%** **Indirect Inguinal - Greater than direct inguinal** **Direct Inguinal - 3%**
371
**Post Test Probability**
Post Test Odds/ (1+ Post Test Odds) Way of calculating the prevalence of a condition in a population that have had an intervention
372
**where are most gastrinomas found?** **Three hallmark features for diagnosis of gastrinoma**
Duodenum, then pancreas **Features:** Fasting hypergastrinaemia Increased basal acid output Secretin Stimulation Positive
373
**What is the remnant of the urachus?** **What is the arterial supply to the bladder?** **What is the venous drainage of the bladder?** **What is the lymph drainage of the bladder?**
Median umbilical ligament Arteries supplying the bladder: Inferior and superior vesical arteries from the **internal iliac artery** Venous drainage of the bladder: Vesicoprostatic venous plexus -\> drains into the internal iliac vein Lymph drainage of the bladder: External iliac nodes (lesser so to the internal and obturator nodes)
374
**indications for CABG** **Conduits for CABG**
LMS/ LAD/ Left Circ Triple Vessel Disease Diffuse Disease **Conduits** Internal Mammary Artery Radial ARtery Long Saphenous Veins
375
**Basophilic and mucoid material between intimal elastic fibers of an artery?**
Cystic Medial Necrosis Seen in age related degeneration + marfan's syndrome
376
**ABx MOA** **Inhibiting Cell Wall FOrmation** **Inhibiting Protein Synthesis** **Inhibiting DNA Synthesis** **Inhibiting RNA Synthesis Cell Membrane**
**Inhibiting Cell Wall FOrmation** Penicillin, Cephalosporin, Glycopeptide **Inhibiting Protein Synthesis** **50S -** Macrolide, Linezolid, Chloramphenicol **30 S -** Aminoglycloside, Tetracycline, **Inhibiting DNA Synthesis** **DNA Gyrase** - Fluroquunilone Metronidazole, Sulphonamide, Trimethoprim **Inhibiting RNA Synthesis** Rifampicin **cell Membrane** Polymxin
377
**Nerve Roots** **SUperior gluteal nerve** **Inferior Gluteal Nerve**
Superior - L4- S1 Inferior - L5 - S2
378
**relations of submandublar gland**
**Superficial**: Lymph Nodes Facial Vein Marginal mandibular nerve + cervical Nerve **Deep:** Facial Artery Mylohyoid Muscle + Hypoglossus Wartons duct Lingual nerve Submandibular Ganglion Hypoglossal nerve
379
**Femoral Nerve** **Roots** **Innervates**
Roots - L2 - L4 Innervates : Lateral cutaneous nerve of thigh, Intermediate cutaneous nerve of thigh, Saphenous nerve Vastus muscles, Quad femoris, Sartorius, Pectineus
380
Calculating Relative risk
Experimental Event Rate / Control Event Rate = Relative Risk
381
**Testing for HIV**
HIV PCR p24 antigen test
382
**Breast Anatomy** **ARterial Supply** **Venous Drainage** **Lymph Drainage**
**Arterial Supply:** Internal Mammary External Mammary (lateral breast) Anterior intercostal arteries Thoraco-acromial artery **Venous Drainage:** Superficial venous plexus --\> subclavian, axillary and intercostal veins **Lymph -** **Axillary Nodes** Internal mammary chains
383
**Crohn's Rectal Disease**
Can't make an ileoanal pouch- lots of cx Need end stoma
384
385
**Muscles attaching to the radius**
Radial **Tuberosity** - Biceps Brachii **Body: Upper third -** Supinator, FDS, FPL **Middle third -** Pronator Teres **Lower part** - Pronator quadratus + Supinator tendon **Lower end:** 3 Grooves for tendons: Extensor muscles (carpi, pollicis longus, indices)
386
**Pressure for pneumoperitoneum**
7-15 mmHg
387
**Right Coronary ARtery supples:** **Left Coronary Artery Supplies:**
**Right Coronary ARtery supples:** RA Part of RV SA node (usually), AV Node Posterior Third of interventricular septum **Left Coronary Artery Supplies:** LA LV Part of RV SA node (less usually) anterior two thirds of interventricular septum
388
**Coronary Sinus** Where is it What drains into it
**Posterior** part of **coronary** **groove** Receives blood from: **great** cardiac vein on **left** **middle** cardiac vein on **right** **small** cardiac vein on **right**
389
**Which veins drain the loose areolar tissue of scalp?**
Emisary veins (potential for spread of infection to cranial cavity)
390
**Perforated appendicitis - where is fluid most likely to collect**
pelvis
391
**Which muscle relaxants do not cause histamine release**
Verocuronium + Suxamethonium
392
**Where does sciatic nerve bifurcate and what into**
Bifurcates at superior aspect of the popliteal fossa: Tibial Nerve and Commmon Peroneal NErve
393
**Mediators of acute inflammation**
Serotonin Histamine Prostaglandin Leukotrienes TNF Interleukins
394
**Structures within the right atrium**
Musculi Pectinati Crista Terminalis Fossa Ovalis opening of coronary sinus
395
**Causes of pruritis ani**
Systemic - DM, High Bili, Aplastic Anaemia, Leukaemia Mechanical - diarrhoea, constipation, anal fissure Infections- Stds Dermatological disease Drugs - Quinidine, Colchicine
396
**Treatment of cyclical mastalgia**
Evening primrose oil, flax seed oil Danazol, tamoxifen
397
**Scrotal Sensation**
Anterior - Ilioinguinal Nerve (L1) Posterior - Pudendal Nerve ( S2-S4)
398
**Branchial Cyst** **Cystic Hygroma** **Locations on examination?**
Branchial Cyst - Anterior to SCM Cystric Hygroma - Posterior to SCM
399
**Structures anterior to posterior in the hilar area:** **Right Lung** **Left Lung**
**Right Lung** **1.** Superior to hilum : SVC, Azygos Vein, Inominate Artery **2.** Behind the hilum:pulmonary ligament, Oesophagus (Superiorly). IVC (inferiorly just anterior to oesophagus ) **Left Lung** **1.** Superior to hilum: Arch of aorta, Subclavian artery, left inominate vein **2.** Behind the hilum: pulmonary ligament, descending aorta, oesophagus (inferiorly)
400
**NPI Equation**
(0.2 x size of tumour) + Nodes + Grade Nodes: 0 nodes = 1 1-3 nodes = 2 \>3 nodes = 3 Grade: 1=1 2=2 3=3
401
**How to differentiate between Anclyostoma Duodenale + Ascariasis infections?**
Anclyostoma - stool microscopy just larvae (if you're lucky) Ascariasis - worms and eggs
402
**Myocardial Action Potential**
**Rapid Depolarisation - Na+ Influx** **Early repolarisation - K+ Efflux** **Plateue - Slow Ca++ Influx** **Final repolarisation - K+ Efflux**
403
**Monteggia vs Galeazzi**
Montegia - Ulnar Fracture + Proximal radioulnar dislocation Galeazzi - Radial Fracture + Distal radioulnar dislocation
404
**Structures passing posterior to lateral malleolus**
Peroneus longus and brevis
405
**Actinomycysosis** **Best Diagnosis?**
Gram Positive Anaerobic Bacilli Diagnosis is through open drainage and culturing of material
406
**Jugular Anatomy** External Internal
External - Superficial to SCM Internal - Deep to SCM in carotid sheath medial to common carotid. External: Formed from joining of posteior division of retromandibular vein + Posterior auricular vein joins subclavian vein and then internal joins more medially to form inominate vein
407
408
**Cervical Drainage**
Through broad ligament to external iliac nodes Uterosacral fold to presacral Accompanying uterine vessels to internal iliac
409
**Which structures are superior/deep to the extensor retinaculum** **What are the attachments of the retinaculum**
Superficial - Veins(cephalic and basilic veins) and Nerves (Dorsal cutaneous of ulnar nerve + Superficial of radial nerve) Deep - Tendons **Attachments** Ulnar side - Psisform And triquetrium Radial side - radial bone
410
Axillary LNs If palpable/image confirmed lymphadenopathy? If no lymphadenopathy?
If palpable/image confirmed lymphadenopathy then proceed to **FNAC** If no lymphadenopathy then **Sentinel Lymph Node biopsy at surgery**
411
**Axillary Artery:** **Parts** **Branches**
**From upper border of first rib (underneath the clavicle) to lower border of teres major** Parts: 1 - Superior to pec minor. Associated with brachial plexus and axillary vein 2 - Behind pec minor Cords of the plexus location are synonymous with their names here 3 - Inferior to pec minor Branches **High Thoracic** **Thoracoacromial** **Lateral thoracic** **Subscapular** **Posterior circumflex** **Anterior circumflex**
412
**Where does the chorda tympani unite with the lingual nerve?**
Near the lateral pyerygoid
413
**Which pharnygeal arches are the following structures derived from:** **Superior parathyroid glands** **Inferior parathyroid glands**
Superior - Fourth Pharyngeal Arch Inferior - Third Pharyngeal Arch
414
**Structures at risk in carotid surgery**
Hypoglossal Nerve Greatuer Auricular Nerve Superior Laryngeal Nerve Common Facial + Internal Jugular Vein
415
Why might the APTT be long in someone with Anti Phospholipid Syndrome?
They might have Lupus Anticoagulant. ALthugh in vivo this is prothrombotic, in vitro it increases APTT
416
**From where does the scaphoid bone get its blood supply?**
From its distal end via a small branch of the radial artery
417
**What goes through:** **Caval Hiatus** **Oesophageal Hiatus** **Aortic Hiatus**
Caval - IVC + Right Phrenic Oesophageal - Oesophagus + Vagal trunks Aortic - Aorta + Thoracic Duct
418
**Nerves at risk in submandinbular gland excision**
Hypoglosal Nerve Lingual Nerve Marginal Mandibular Nerve
419
**Limited liver mets in colorectal malignancy....**
Chemotherapy + Resection. Radiofrequency ablation for those not fit for surgery
420
**Actions of corticosteroids**
**Metabolic** Decreased uptake/utilisation of glucose Increased gluconeogenesis Increased hyperglycaemia Increased protein catabolism Lipolysis **Regulatory** Negative feedback on hypothalamus CNS - decreased vasodilation/ decreased fluid exudation Decreased osteoblastic/ Increased osteoclastic Decreased inflammation
421
**Branches of the vagas nerve**
Right - Recurrent laryngeal at the level of Right Subclavian artery in neck Left - RLN at level of aortic arch Both give off: **Superior and Inferior cervical cardiac branches** Right - Both Posterior to subclavian Left - Superior branch between arch of arota and trachea Whereas inferior tracks along with the vagus **Thoracic and cardiac branches (in thorax)**
422
**Where do the different rotator cuff muscles attach to fibrous capsule**
Superior - Supraspinatus Anterior - Subscapularis Posterior - Teres Minor + Infraspinatus
423
**left renal vein interesting anatomy**
It crosses the aorta just inferior to the SMA Receives tributaries from the testicular vein, suprarenal vein + inferior phrenic vein Level is at about L1/L2
424
**Feeding in oesophageal perforation**
Should be through TPN as any other feeding can cause delayed healing or leak through perforation
425
**Treatment of pancreatitic pseudocyst**
Endoscopic or radiological cystgastrostomy
426
**nerve roots for** **Superior Gluteal nerve** **Inferior Gluteal nerve**
SGN - L4 - S1 IGN - L5 - S2
427
What muscle is associated with the pudendal canal? Which space is it located within?
Obturator Internus Ischioanal fossa
428
Bacteria most commonly associated with synergistic gangrene
E Coli + Bacteroides
429
**Where are musculi pectinati predominantly ofund**
Right atrium - internal muscular ridges on the anterolateral surface of the chamber
430
**Lymph drainage of ureter**
Upper - Para Aortic Lower - Common Iliac
431
**Flattened Face =**
**Le Fort 2 or Le Fort 3 fracture**
432
**What is in the lung pleural reflection?**
Bronchus, Pulmonary Artery, Pulmonary Vein
433
**Relations of Coeliac Trunk**
Anterior - Lesser Omentum Right - Right coeliac ganglion + caudate lobe of liver Left - Left coeliac ganglion + gastric cardia Inferiorly - pancreas + renal vein
434
Laparotomy approach in children
Transverse Supra Umbilical incision
435
**Trotter's Triad**
Nasopharyngeal Carcinoma Unilateral Conductive Hearing Loss Ipsilateral Facial Pain Ipsilateral Palatal Paralysis
436
**Thoracic Duct Path**
Starts at joining of left and right lumbar trunk + intestinal trunk (cisterna chylii) Traverses diaphragm through aortic hiatus then ascends between aorta and azygos vein Terminates in the left inominate vein
437
Process of gastric dumping syndrome
Load enters the jejunum fast --\> Water enters the lumen --\> Distension of the jejunum and then diarrhoea Also causes insulin release (hypoglycaemia )
438
439
**Salter Harris Classification System**
**I ( Straight) -** Through Physis **II (Above)** - Through physis and above to involve metaphysis **III ( Lower)** - Through physis and below to involve epiphysis **IV (Through)** - Through metaphysis, physis and epiphysis **V (****Everything Ruined)** - Crush / Compression
440
**Ansa Cervicalis** **Roots** **Innervates** **Location**
Roots - Upper C1, Lower C2-C3 Innervates - Sternohyoid, Sternothyroid, Omohyoid - innervation comes from **inferior part of muscle** Location - Anterior to carotid sheath within the pre tracheal fascia
441
**Where do these arteries originate?** **Artery of Vas** **Cremasteric Artery**
**Artery of Vas -** Inferior Vesicular Artery **​Cremasteric Artery -** Inferior epigastric artery
442
**What does mandibular nerve innervate (motor)**
Masseter Temporalis Medial and Lateral Pterygoid Tensor Veli Palatini Tensor Tympani Mylohyoid Anterior belly of digastric
443
**Quadratus Lumborum** Origin Insertion Action Innervation
Origin - Medial aspect of iliac crest and iliolumbar ligament Insertion - 12th Rib ACtion - Pulls rib cage inferiorly. Lateral flexion of spine Innervation - Anterior Rami of T12-L3
444
**Multiple lytic / lucent appearances on X Ray** **(Soap Bubble)**
Osteoclastoma (Giant Cell Tumour)
445
**Where is the coeliac plexus** **What contribuets to it**
Plexus is at T12/L1 inbetween oesopahgus (anterior) and aorta (posterior) It receives contributions from Greater splanchnic nerves, lesser splanchnic nerves, Vagus Nerves and Phrenic Nerves
446
**Innervation to external urethral sphincter** **Autonomic Control of the bladder** **Innervation to internal urethral sphincter**
**External -**Pudendal Nerve (L2-L4) **Autonomic control of bladder -** Hypogastric plexuses **Internal -** Sympathetic fibers from T10 - L2 through inferior hypogastric plexus
447
How does tranexamic acid work\>
Inhibits plasmin which is responsible for fibrin degradation
448
**Location of the brcahial plexus in the neck**
Roots enclosed within an extension of prevertebral fascia Deep to platysma, omohyoid, transverse cervical artery + supra clavicular nerves.
449
**Causes of avascular necrosis** **Plastic RAGS**
Plastic Rags Pancreatitis Lupus Alcohol Steroids Trauma Idiopathic, Infection Caisson Disease, Collagen Vascular Disease Radiotherapy, RA Amyloid Gaucher Disease Sickle Cell Disease
450
**Directions of External Carotid Branches**
Anterior: Superior Thyroid Lingual Facial Posterior: Occipital posterior auricular Deep: Ascending Pharyngeal
451
452
**Where is the intercostal bundle**
Lies in the **subcostal groove** Vein is most superior (least easily damaged) Artery Nerve (most inferior)
453
**Cutaneous innervation of foot** Dorsolateral lateral plantar dorsum first web space proximo-medial heel
**Dorso**-**lateral** - Sural **Lateral** **Plantar** - Lateral Plantar Nerve **Dorsum** - Superficial peroneal **First Web Space** - Deep Peroneal **Proximo-medial** - Saphenous nerve **Heel** - Calcaneal Branch of Tibial Nerve
454
**Treatment of haematocele?**
Surgical Exploration + Repair through scrotal approach
455
**Where does the cervical sympathetic chain lie?**
Between the: Carotid Sheath (anteriorly) Prevertebral Fascia (Posteriorly)
456
**Biceps Femoris** Origin Insertion Innervation Blood Supply
Origin - Ischial Tuberosity (long), Linea aspera/ Supracondylar ridge of femur (short) Insertion - Fibular Head Innervation - Sciatic nerve (Tibial - Long, Common Peroneal - Short) Blood Supply - Profunda Femoris, Inferior Gluteal, Superior Politeal Branches
457
**What influences release of histamine from enterochromaffin cells in stomach?**
Elevated Serum Gastrin
458
**Grading of knee collateral injury**
1 - Soem fibre disruption, no laxity (Conservative) 2 - Some ligament laxity (casting/ splinting) 3 - Joint instability, ligament is torn (Surgical Reconstruction)
459
**Statistics:** **Likelihood ratio for positive test result** **likelihood ratio for negative test result**
PTR - Sensitivity/ (1-specificity) NTR - (1-sensitivity)/specificity
460
**Describe lesser omentum**
Double layer of peritoneum extending from liver to the -stomach and duodenum Divided into two portions: hepatogastric ligament (attaches to lesser curve of stomach), hepatoduodenal ligament WIthin the folds - left and right gastric arteries hepatic artery, CBD, Portal vein, LNs, and hepatic plexuses
461
**Describe Greater Omentum**
Double layer of peritoneum extending from greater curvature of stomach over the top of the small intestines and then coming back to cover the transverse colon Subdivisions: Gastrophrenic, Gastrocolic, +Gastrosplenic Ligament Blood Supply - Left (from splenic artery) and Right (gastroduodenal branch) Gastropeiploic Arteries
462
**Posterior Triangle of neck contents**
**Nerves:** - Accessory nerve, phrenic nerve - Trunks of brachial plexus Cervical Plexus Branches - Supraclavicular nerve, Transverse Cervical Nerve, Greater Auricular Nerve, Lesser occipital nerve **vessels:** EJV, Subclavian artery **Muscles;** Inferior belly of omoyhyoid, Scalene **Lymph Nodes;** supraclavicular, occipital
463
**What is the only muscle of the foot not innervated by the tibial nerve?**
Extensor Digitorum brevis ( Common Peroneal nerve)
464
**Pituitary Anatomy**
In the sella turcica of the sphenoid bone. Covered by dura here. Originates from rathkes pouch (pharynx) Anterior side conected to hypothalamus by portal vein whereas posterior side connected via neurones **anterior hormones:** GH, LH, FSH, ACTH, MRH, TSH **posterior hormones:** ADH, Oxytocin
465
**Sciatic nerve topography**
Convergence of L4-S3 Anterior rami at the inferior border of piriformis and emerges through the inferior part of greater sciatic foramen From here it descends underneath gluteus maximus Splits into Common peroneal + Tibial nerve superior to popliteal fossa
466
**Anterior Interosseus Nerve Injury**
Loss of pronation of the arm (pronator quadratus) Loss of flexion of lateral fingers and thumb (FPL + FDP)
467
**Greater Sac** **Lesser Sac**
**Greater Sac** Peritoneum encasing the majority of the intraperitoneal abdomen (save the lesser sac) **Lesser Sac** ​ Is the encasing of the cavity that is formed by the greater and lesser omentum. Margins: Anterior - Quadrate lobe of liver, stomach, lesser omentum, gastrocolic ligament Posterior - left kidney, adrenal gland, pancreas Inferior - Greater Omentum Superior - Liver Lateral - Spleen and ligaments anterior/posterior to the spleen
468
**lateral malleolus** **Posterior structures**
Posterior: Peroneus longus and brevis tendons Sural nerve Short Saphenous Vein
469
**Causes of thrombocytopenia** **Severe** **Moderate**
Severe- ITP, TTP, DIC, Haem Malignancy Moderate - HIT Drugs - quinine, diuretics, sulphonamide, thiazide, aspirin Alcohol liverdisease hypersplenism Viruses Pregnancy SLE/Antiphospholipid Syndrome B12 Deficiency
470
**What are the branches of the maxillary artery**
Inferior alveolar Middle meningeal
471
**Adductor Longus** Origin Insertion Innervation
Origin - Anterior body of pubis Insertion - middle third of linea aspera Innervation - Obturator Nerve (L2-L4)
472
Adults: Where does spinal cord terminate Where does dural sac end
Spinal cord - L1 (L3 in newborns) Dural Sac - S2
473
**Laxatives** Bulk forming laxatives Osmotic Laxatives Stimulant Laxatives
**Bulk forming laxatives** Bran, Psyllium, Methylcellulose **Osmotic Laxatives** magnesium sulphate, magnesium citrate, sodium phosphate, sodium sulphate, potassium tartate, polyethylene glycol, docusate **Stimulant Laxatives** Senna Picosuphate ricinoleic acid bisacodyl
474
**Types of DCIS**
Comedo - Linear branching microcalcificaition Cribiform, micropapillary - multifocal
475
**Pectoralis Major** Origin Insertion Nerve SUpply Actions **Pectoralis Minor** Origin Insertion Nerve SUpply Actions
**Major** Origin - medial two thirds of clavicle, manubrium and sternocostal angle Insertion - lateral edge of bicipital groove of humerus Nerve SUpply - Lateral Pectoral nerve Actions - Adducts + Medial ROtates humerus **Minor** Origin - Costochondral Junctions of third to fith ribs Insertion - Coracoid process of scapula ( medial border+ superior surface) Nerve SUpply - Medial + Lateral Pectoral Nerve Actions - Draws scapula inferiorly/ anteriorly against thoracic wall.
476
**What drains into the** **SMV** **IMV**
SMV - up to the splenic flexure IMV - beyond the splenic flexure
477
**Regarding Nerve Transection Injuries - what is the prognosis/ course of action** **Clean Simple Transection** **Complicated Transection**
Clean Simple Transection - the proximal axon will degenerate back to the first node of ranvier. Wallerian degeneration will causae the distal axon to degenerate too. The proximal axon will grow at a rate of 1mm per day Complicated Transection - Axonal growth will be impaired in the setting of fracture, haemorrhage, infection etc... Therefore practice is to delay approximation of the distal+proximal axons for a few weeks
478
**Where does the female urethra drain lymphatic wise too**
Internal Iliac Nodes
479
**Where is a hypervascular bone primary most likely to come from**
Kidney
480
**Main difference between T Tests/ Fishers + Chi**
T Test - Compares normally distributed data Fishers + Chi - Tests categorical data
481
**Quadrate lobe**
Functionally part of left lobe of liver Anatomically associates with right lobe of liver
482
**Oesophagogastric Junction Tumours**
Type 1 - true oesophageal (barrett's) Type 2 - of the gastric cardia/ intestinal metaplasia Type 3 - Sub cardial cancers that spread across the junction Depending on staging these are treated by oesaphogogastrectomy
483
**Innervation of lacrimal duct**
PNS Greater Petrosal nerve (Branch of CNVII in the facial canal) --\> Pterygopalatine ganglion ---\> gland innervated through zygomatic / lacrimal branches of maxillary nerve
484
What is the thoracic outlet?
Where the subclavian vein, artery and brachial plexus exit the thorax. In between first rib and the clavicle
485
**Which nerve supplies abductor pollicis longus?**
Radial
486
Ear Nerves: What supples sensation to external ear? What innervates stapedius? What innervates tensor tympani?
What supples sensation to external ear? - Greater Auricular Nerve (Cervical Plexus C2-C3) + Auriculotemporal nerve ( Mandibular Nerve) What innervates stapedius? Nerve to stapedius ( CN VII) What innervates tensor tympani? CN V
487
Composition of cervical canglion
Superior : C1 - C4 Middle: C5- C6 Inferior: C7-C8
488
**Any rupture of urethra from membarnous urethra onwards ... Where doe urine accumulat?**
Connective tissue of the scrotum: Fascia adherence prevents urine from going posteriorly or laterally so it tracks retrograde
489
**Borders of the** **Deep Perineal prouch** **Superficial Perineal Pouch** **Muscles of perineal body**
**Deep Perineal pouch** Superiorly - fascia of perineal floor Inferiorly - Perineal membane **Superficial perineal pouch** Superficial - perineal membrane Inferiorly - Superficial perineal fascia **perineal body:** Just superior to the anus. Muscles - Levator Ani, Bulbospongiosus, Transverse perineal muscles, External Anal Sphincter, External urethral sphincter.
490
**Duke Classification System**
A - Confined to bowel B - Involving bowel wall C - Nodal Mets D- Distant mets
491
**Biopsy features of barret's oesophagus**
Goblet Cell metaplasia Oesphageal Glands
492
**Which rectal cancer patients require neoadjuvant radiochemotherapy**
T4
493
**Radial Nerve Injury in the :** **Shoulder** **Arm** **Forearm**
Shoulder - Triceps Long Head Arm - Impairment to elbow extension Forearm - Wrist, finger extension and supination
494
**Contents of** **Superficial perineal Pouch** **Deep Perineal Pouch**
Deep: Urethral Sphincter Urethra Vagina Deep Transverse Perineal Muscle Superficial: Erectile Tissue Superficial Transverse, Ischiocavernosus, bulbospangiousis Bartholin's Glands
495
**Levator Ani Muscles**
Three paired muscles - pubococcygeus, puborectalis, ileococcygeus **Perineal Body to** pubic bodies of hip bone(anterior), to obturator internus (lateral), ischial spines of hip bone (posterior)
496
**Relations of the prostate gland**
Anterior - Venous PLexus, Pubic Symphysis Posterior - Denonvilliers Fascia, Rectum, Ejaculatory Ducts, Lateral - Venous Plexus, Levator ani
497
**First Line therapy for Nasopharyngeal Carcinoma**
Radiotherapy
498
**Tetralogy of Fallot** **Feature**
VSD Overarching Aorta Right Ventricular Hypertroply RV outflow Obstruction Right to left shunting
499
**Oxyphil Cells on thyroid histology =**
Follicular carcinoma
500
**Thing in relation to carotids**
Inferior thyroid artery passes posterior to common carotids Thoracic Duct crosses the left common carotid Recurrent laryngeal nerve crosses the right common carotid
501
**larynx:** Superior to vestibular folds Between vestibular folds, superior to vocal cords vocal cords to inferior bord of cricoid cartilage
**Vestibule -** Superior to vestibular folds **VEntricle -** Between vestibular folds, superior to vocal cords **Infraglottis -** vocal cords to inferior bord of cricoid cartilage
502
**Differentiating feature of** **Central Horner's** **Pre Ganglionic Horner's Post ganglionic Horner's**
**Central Horner's -** Anhidrosis of ipsilateral face arm trunk * *Pre** **Ganglionic** **Horner's** - Anhidrosis of ipsilateral face * *Post ganglionic Horner's -** Anhidrosis of NOTHING
503
**Which surgical device is good for managing splenic bleeding?**
Argon plasma coagulation system
504
**Which arteries make up kiesselbach's plexus?**
Greater Palatine artery + SPhenopalatine Artery ## Footnote **(Both Maxillary Artery Branches - From ECA)**
505
**What is a bankart lesion**
Injury to anterior inferior glenoid labrum This can cause recurrent anterior shoulder dislocation
506
**Renal Tubular Acidosis** **Type 1** **Type 2** **Type 4**
Type 1 (Distal Tubule) - Impaired H+ Secretion, Hypokalaemia Type 2 (Proximal Tubule)- Impaired Bicarb Reabsorption, Hypokalaemia Type 4 (Collecting Ducts) - Addison's/Ald Resistance Hyperkalaemia
507
**If the external fistula opening is at th following o clock where can you expect to find the internal opening** 2 o clock 4 o clock 7 o clock 11 o clock
2 o clock + 11 o clock are **anterior** - so the internal opening will be in a straight line from the external opening at the same o clock trajectory. 4 o clock + 7 o clock are **posterior** - so the internal opening will be in the midline at **6 o clock** after havine a curvilinear route
508
**What are the posterio/medial relations of the left lobe of liver?**
Proximal stomach + abdominal oesophagus
509
**Which valves have chordae tendinae**
Mitral and Tricuspid Mitral - 2 Cusps (one anterior)
510
**Which two cranial nerves originate from between the posterior cerebral artery and the superior cerebellar artery**
Trochlear Nerve + Occuluomotor nerve
511
**Which clotting constituents are consumed most quickly in DIC**
V, VIII and platelets
512
**Layers of bowel wall**
Mucosa Submucosa **Submucosal Plexus (Meissner's)** Muscular Layer (First circular and then longitudinal - **Auerbach's plexus is in between them)** Serosa
513
**Dark blood on aspiration in priapism?**
This indicates low flow priapism - the penis needs to be decompressed by further aspiration
514
**Where are the motor root fibers of the trigeminal nerve?**
In the pons - distinctly not part of the trigeminal ganglion
515
**Carcinoid Tumours - management** **\<2 Cm And in the appendix** **\>2 cm**
\<2 cm and in appendix - **Just appendicectomy** \>2 cm - **Radioisotipe scanning.** If radioisotope scanning demonstrates --\> lymph involvement then right hemi if margins on histology demonstrate compromise --\> right hemi
516
517
**Contents of anterior triangle of neck**
Submandibular Gland Supra and infrahyoid muscles, Digastric Muscle Carotid Sheath ( Vagus, Carotid, Jugular) Ansa Cervicalis, Internal Jugular Vein, External jugular Vein, Anterior Jugular Vein
518
**Associations of oesophageal atresia**
Distal tracheoosophageal fistula is teh common varient Associated with VACTERL (**Vertebral** anomalies, **anal** atresia, cardiac anomalies, thracheosophageal fistula/esophageal fistula, renal anomalies, limb defecvts).
519
**Long Thoracic Nerve**
Ventral rami of C5- C7 ---\> inferior route iether infront or behind middle scalene muscle. Descends overlying the serratus anterior muscle
520
**Renal stoens associated with...** **inborn errors of metabolism** **purine metabolism disorders** **infection**
**inborn errors of metabolism** - Cystine (radio-dense) **purine metabolism disorders -** Uric Acid (radiolucent) **infection -** Struvite (radio-dense)
521
**In children - are teratomas usually malignant or benign**
Benign - so if there is a testicular mass in a child with ?metastatic disease its probably not teratoma
522
523
**Where does the root of the :** **Right lung pass** **Left Lung Pass**
Right lung - SVC and Right Atrium Left Lung - Desceinding Aorta, Aortic arch
524
**Pancreatic Relations**
Posterior: IVC, CBD, Renal Veins, SMA, SMV, Portal Vein, Diaphram, Psoas, Kidney, Adrenal, Aorta Anteror: 1st Part of Duodenum, Pylorus of stomach, Gastroduoednal ARtery, SMA + SMV, Stomach, DJ Flexure, Splenic Hilum Superior: Coeliac Trunk, SPlenic artery, Common Hepatic ARtery
525
**Mutation associated with** **FAP** **Lynch** **Cowden** **MYH associated Polyposis** **Peutz jehgers**
FAP - APC Lynch - DNA mismatch repair genes Cowden - PTEN MYH associated polyposis - MYH Peutz Jehgers - STK11
526
Management of \>1 cm sessile serrated polyps
Polypectomy
527
**Fracture Healing Stages**
Clot and haematoma formation Clot Organisation ( Collagen) Bone production from periosteum Cartilage production (mesenchymal cells) Callus formation ( connective tissue + hyaline cartilage) Endochondrol ossification of cartilage **Trabecular bone formation --\> Compact bone by osteoclast mediated resorption of trabecular bone**
528
**types of colonic peristalsis** **what does circular muscle do** **what does longitudinal muscle do**
Colonic peristalsis: Mas movement - waves of peristalsis through the whole colon Segmental Contraction - Local contractions to maximise absorption Antiperstaltic contractions - slow down food bolus toward ileum Circular muscle - contracts behind food bolus longitudinal muscle - propels food bolus forwards
529
**WHere do the following originate** **Long Head BIceps** **Long Head Triceps**
Long head biceps - Supragelnoid Tubercle Long head Triceps - Infraglenoid tubercle
530
531
**Iliacus** Origin Insertion Innervation Action Arterial Supply
Origin - Superior 2/3 of iliac fossa Insertion - Lesser trochanter of femur Innervation - Femoral nerve Action - Thigh Flexor Arterial Supply - Femoral Artery
532
**What are the end branches of posterior tibial artery**
Medial and lateral planter arteries
533
**Hip Fracture management** Subtrochanteric Reverse Oblique Inter-Trochanteric
Subtrochanteris - Intramedullary Nail Reverse Oblique - Intramedullary Nail Inter-trochanteric - DHS / IM Nail if unstable
534
**Spinal Cord Lesions: Signs and causes** Dorsal Column Spinothalamic Central Cord Lesion Osteomyelitis Infarction Cord Compression Brown- Sequard
**Dorsal Column** - Vibration and proprioception lost. Tabes Dorsalis, SACD **Spinothalamic -** Loss of pain/temp. Syringomyelia **Central Cord Lesion** - Syringomyelia **Osteomyelitis -** Cervical region / Thoracic Region. Usually back pain **Infarction -** 2o to aortic surgery..Doral Columns Signs **Cord Compression -** UMN signs. Malignancy, haematoma, fracture **Brown- Sequard -** Hemisection of spinal cord. Ipsilateral paralysis, loss of proprioception and fine discrimination. Contralateral loss of pain and temp
535
**What test can be used to compare two or more sets of non-parametric data?**
Kruskal Wallis One way variance test
536
**Relations of the IVC**
Anterior: Small Bowel, 1 + 3 of duodenum Head of pancreas, Liver, Bile Duct RIght common iliac, Right gonadal artery Posterior: right renal artery, right psoas, right sympathetic chain, coeliac ganglion
537
**Borders of anatomical snuffbox**
Posterior - EPL Anterior - APL, EPB Proximal- Radial Styloid Process Distal - Apex of snuffbox Floor - Scaphoid + trapezium
538
**layers of periosteum**
Outer -Fibrous layer (Fibroblasts) Inner - Cambium layer ( osteogenic - containing osteoid progenitor cells) Sharpey's fibers connect it to bone
539
**What are the compartments of the knee joint** **Bursae of knee joint** Anterior Lateral Medial **Which meniscus is attached to respective collateral ligament**
**Compartments** Tibiofemoral Patellofemoral **Bursae of knee joint** Anterior - Prepatellar Bursa, Deep Infrapatellar bursa (tibia and patellar ligament, Superficial infrapatellar bursa (tibial tuberosity and skin) Lateral - Between: i) lateral Gastroc and joint capsule, ii) lat colat lig + biceps tendon, iii) lat colat lig + popliteus tendon Medial - Between: i) medial gastroc + joing capsule ii) medial colat lig + pes anserius tendons, iii) membranosus + medial tibial condyle + medial gastroc head **Medial meniscus is attached to respective collateral ligament**
540
**Musculocutaneous nerve continues into the forearm as the..**
Lateral cutaneous nerve of the forearm
541
**Adductor Canal**
Lateral- Vastus Medialis Posterior - ADductor Longus and MAgnus Anterior - Sartorius Contents - Saphenous Neve, Superficial Femoral Vein, Superficial Femorl ARtery
542
Drugs to manage VT
Amiodarone Lidocaine Procainamide
543
**Brachial Plexus** **What are the roots of the BP ensheathed within in neck?** **What structures overly the brachial plexus in the neck?**
In the neck the BP is enclosed within an extension of the prevertebral fascia In the neck the brachial plexus is deep to: Platysma, Supraclavicular Nerves, Inferior belly of omohyoid, Transverse Cervical Artery. They then pass deep to the clavicle and suprascapular vessels on the way into the axilla
544
**Why is facial vein more at risk than facial artery in submandibular gland surgery?**
The facial vein is more superficial a structure - it descends on the surface of the mandible and then superficial to the gland itself. The facial artery ascends from deep to the artery. then overlies the mandible
545
**Branches of the mandibular nerve**
Auriculotemporal Lingual Inferior Alveolar Nerve to mylohoid Mental
546
**What are the subtriangles of teh anterior neck triangle?**
Submandibular (Digastric) - Gland, Nodes, Facial A+V, CNXII **Digastric Muscle** Muscular - Strap Muscles, EJV **Omohyoid Muscle** (Anterior - Mylohyoid(CN V3), Posterior - Facial) Carotid - Sheath, Ansa Cervicalis
547
List Some Cardiac Inotropes
Phosphodiesterase Inhibitors Adrenaline Noradrenaline Dopamine Dobutamine
548
**Bladder cancer Treatment**
Superficial - TURBT Superficial but high grade/risk, recurrence - intravesical chemotherapy \>T2 - radical cystectomy
549
**Lymphatic Drainage of:** **Scrotum** **Testes** **Prostate**
Scrotum - Inguinal Testes - Para- Aortic Prostate - Internal Iliac
550
Ligaments of the Liver
**Ligamentum Teres** Remnant umbilical vein - joins left portal vein branch in porta hepatis **Ligamentum Venosum (Posterior)** Remnant of ductus venosus - **Falciform Ligament** Double peritoneal fold from umbilicus to anterior hepatic surface where divides into coronary and left triangular ligaments
551
**Pelvic Floor Muscles** Floor Lateral Wall Where is the perineal body
**Pelvic Floor:** Floor - Levator Ani (Pudendal Nerve - Pubococcyg., iliococcyg, puborectalis), Coccygeus Lateral Wall - Piriformis + Obturator Internus The perineal body is inbetween the urogenital and rectal hiatus
552
**Anatomical boundaires of the perinuem**
Diamond shaped structure Anteriorly - Pubic Symphysis Posteriorly - Tip of coccyx Laterally - inferior pubic rami, inferior ischial rami and sacrotuberous ligament
553
**Muscles of the perineal body**
Levator Ani Bulbospongiosus Superficial and deep transverse perineal muscles external anal sphincter external urethral sphincter
554
**Nerves associated with pharyngeal arches**
I - Trigeminal II - Facial III - Glossopharyngeal IV - Vagus VI - Vagus + RLN
555
556
**Which abdominal viscera are retroperitoneal?**
Adrenals, Kidneys, Ureters Aorta + IVC Rectum Duodenum ( except proximal 2cm ), oesopahgus, pancreas Colon - not transverse or sigmoid
557
**Which muscles cross the internal jugular vein?**
Omohyoid Sternocleidomastoideus
558
**Lymph Drainage of the female urethra**
Internal Iliac Node (Whole length of the urethra)
559
**Branches of thoracoacromial artery**
Pectoral - Breast and Pectorals Acromial - Deltoid and joint capsule Clavicular - sternoclavicular joint Deltoid - travels between pec major and deltoid in deltopectoral groove
560
561
**Structures passing behind the medial malleolus:** **Anterior to Posterior**
Anterior : Tibialis Posterior Flexor Digitorum Lonugs Posterior Tibial Vein Posterior Tibial Artery Nerve Flexor Hallucis Longus
562
563
**Treatments for extravasation injury** Doxirubicin Contrast media, TPN, Vinca Alkaloids Vinca Alkaloids ALone
Doxirubicin - COld Compress Contrast media, TPN, Vinca Alkaloids - Hyaluridonase Vinca Alkaloids ALone - Warm Compress
564
**Breast Treatment** **When to use chemo** **When to use radio**
Chemo: Downstaging \>Grade 3 Lesions Axillary node Disease Radio: WLE Post Mastectomy - Large lesion, High Grade Lesion, vascular invasion
565
**What is in the middle mediastinum (5)**
Pericardium Heart Aortic Root Arch of azygos vein Primary bronchi
566
**Defect in osteopetrosis**
Osteoclast function impaired - So defective bone resorption
567
**Cardiac Surgery Qs** **Incisions** **Cardiopulmonary bypass -** What is cannulated How much heparin **Conduits for bypass**
**Incisions - Midline sternotomy/ Left Submammary Incision** **Cannulated -** Aortic Roots + Right Atrium Heparin - 30,000 iU of unfractionated **Bypass Conduits-** Internal mammary, Radial, Long saphenous
568
Borders of the triangular interval Content
Medial - Long head of triceps Lateral - Shaft of humerus Superiorly - Teres major Transmits the radial nerve from the axilla into the arm
569
**HIV Testing: Window for positivity** p24 antigen Antibody
p24 antigen : 3-4 weeks Antibody: 4-6 weeks
570
**Glasgow Pancreas Score**
P - PaO2 \<8 A - Age \>55 N - Neutrophils \>15 C - Calcium \<2.0 R - enal Urea \>10 E - Enzymes LDH Raised / AST raised A - ALbumin \>32 S - Hyperglycaemic
571
**Stucturs in the right atriu**
Musculi Pectinati Crista Terminalis Opening of coronary sinus Fossa Ovalis
572
**Artery Locations:** **Anterior Tibial** **Posterior** **Tibial** **Peroneal**
Anterior TIbial - In the anterior compartment (very close to deep peroneal nerve) Posterior Tibial - In the deep posterior compartment - more medial Peroneal - In the deep posterior compartment - more lateral Both of these are very close to the fibula + tibial nerve (their veins are either side of the tibial nerve)
573
**Difference histologically between necrosis apoptosis**
Necrosis: Cell Membrane Problems Lysosomes Cellular Swelling Inflammation Apoptosis: Fragments of nucleus No inflammation Cell Membrane Intact No lysosomes
574
**Structures posterior to medial malleolus:** Anterior to posterior
Tom Dick and Very Nervous Harry Tibialis Posterior Flexor Digitorum Profundus Tibial Artery and Vein Tibial Nerve ( supplies all intrinsic foot apart from Extensor hallucis Longus - Common peroneal Nerve) Flexor Hallucis Longus
575
**Borders of the tympanic cavity**
Lateral - Tympanic membrane Medial - Bulge formed by **facial nerve**/ lateral wall of inner ear Roof - Temporal bone Floor - Temporal Bone (known as jugular wall) related to **internal jugular** Anterior Wall - bony plate. auditory tube + tensor tympani. related to **ICA** Posterior wall - mastoid wall borders the cavity from mastoid air cells. Mastoid antrum is a connection the air cells
576
**Borders of the antecubital fossa** **Where does the brachial artery bifurcate** **Where does the ulnar artery lie in relation nerve**
Lateral - Brachioradialis Medially - Pronator Teres Superiorly - Line between the humeral condyles Floor - Supinator + Brachialis Contents - Medial to lateral - bicept tendon -\> brachial artery -\> median nerve Brachial artery bifurcates - radial head Ulnar artery is lateral to ulnar nerve
577
**Layers of the SCALP?**
Skin Dense Connective Tissue Epicranial APoneurosis Loose Areolar Tissue ( Emissary Veins here) Periosteum
578
**Pterygopalatine Fossa** **Borders** **Contents**
**Borders: Anterior**- Posterior wall of maxillary sinus **Posterior -** Sphenoid bone (pterygoid process) **inferior -** palatine bone and canal **Superior -** inferior orbital fissue **medial -** perpendicular plate of palatine bone **lateral -** pterygomaxillary fissure **Contents:** Maxillary Nerve (Foramen Rotundum opens here) Maxillary artery Pterygopalatine ganglion (Greater petrosal nerve of VII)
579
**Infratemporal Fossa** Borders Contents
Borders: **Lateral -** Mandible condyle/ramus **medial -** lateral pterygoid plate, palatine + superior constrictor muscles **anterior** - posterior body of maxillary sinus **posterior -** carotid sheath **roof -** sphenoid wing **floor -** medial pterygoid **contents** related to ovale and spinosum medial and lateral pterygoids mandibular nerve, otic ganglion, chorda tympani, maxillary artery + vein Middle Meningeal vein (Artery is associated with the roof)
580
**vertebral Column** Arches- Pedicles - Lamina - Spinous Processes - Rib articulations
Arches - exend posteriorly from the body to create the vertebral foramen through which spinal cord is transmitted Pedicles - Body to transverse process Lamina - transverse to spinous process SPinous Processes - Posterior most structure in the vertebrae. Cervical are bifid **Rib -** Superior + inferior demi facet - either side of vertebral body articulates with inferior/superior rib Costal facet of transverse spinous process - articulates with rib corresponding to that vertebrae
581
**Which back muscles are involved in rotating the head?** **Of the deep spinal muscles:** **What are the intermediate and deep ones**
Splenius Capitis + Cervicis Intermediate : Medial to lateral Spinalis, Longissimus, Iliocostalis Deep: Multifidus + Semispinalis
582
**Forearm Compartments**
**Anterior Superficial:** Flexor Carpi Ulnaris Palmaris Longus (median nerve deep to this near wrist) Flexor carpi Radialis Pronator Teres **Anterior Intermediate:** Flexor Digitorum Superficialis **Anterior Deep:** Flexor Digitorum Profundus, Flexor Pollicis Longus, Pronator Quadratus **Posterior Superficial:** Brachioradialis Extensor Carpi Radialis longus + brevis Extensor Digitorum Extensor Digiti Minimi Extensor carpi ulnaris Anconeus **Posterior Deep:** Supinator Abductor Pollcis Longus Extensor Pollicis Longus + Brevis Extensor indicis proprius
583
Which flexor of the arm is innervated atypically?
Brachioradialis - innervated by the radial nerve
584
**Nerves of lumbar plexus (6)**
**Lumbar Plexus : L1-L4** **IlioHypogastric - L1.** Internal Oblique + Transversus Abdom. **Ilioinguinal - L1.** Internal Ob + Transvers. Abd. Enters inguinal canal by piercing through the internal oblique **Genitofemoral - L1-L2.** Genital Branch - Cremaster Musc. Lateral Cutaneous Nerve of Thigh - L2-L3 **Obturator Nerve- L2-L4.** Obt. Extern, Adduct Long + Mag + Brev. (sometimes pectineus) + Gracilis **Femoral Nerve - L2-L4.** Quad Femor. Vastus Musc. Sartorius. Pectineus. Iliacus
585
**Branches of thyrocervical trunk**
**Inferior Thyroid** **Suprascapular** **Transverse Cervical** The subscapular artery from the axillary artery (3rd part) anastamoses with the suprascapular + transverse cervical
586
**Branches of the costocervical trunk**
**superficial intercostal** **deep cervical**
587
**What happens to the dorsal scapular artery?**
Dorsal Scapular Artery: **Joing the superficial cervical artery (Thyrocervical Trunk and becomes:** **Transverse Cervical** This has superficial and deep branches
588
589
**Branches of the sacral plexus**
S1-S4 (sciatic receives lumbar roots L4-L5) **Superior Gluteal Nerve - L4, L5, S1** Glut Med+ Min. TFL **Inferior Gluteal Nerve -** **L5 S1 S2.** GLut Max **Sciatic Nerve** - **L4 - S3.** Posterior thigh muscles + Part of aductor magnus. All muscles of lower leg via common peroneal + tibial branches **Posterior Cutaneous nerve of the thigh - S1 - S3** **Pudendal Nerve - S2-S4.** External urethral + anal sphincter. Levator Ani + perineal muscles **Nerve to piriformis** **Nerve to quadrator femoris** **Nerve to obturator internus**
590
**Piriformis**
Nerve - Nerve to piriformis S2-S4 to Lesser trochanter
591
**What do the following anastamose with + Signficance:** **Inferior Thyroid Artery** **Deep Cervical Artery** **Dorsal Scapular Artery**
**Inferior Thyroid Artery** Anastamoses with the superior thyroid artery --\> This is significant in Subclavian Steal as retrograde flow happens through this link **Deep Cervical Artery** Descending branch of occipital artery --\> Again another site of collateralisation in Subclavian Steal **Dorsal Scapular Artery** Circumflex Scapula Artery (from subscapular artery) + Suprascapular artery --\> Forms the scapular anastamosis.