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1
Q

Due to defect in melanocytes dis?

A

1) vitiligo
2) piebaldism
3) lentigens due to inc melanocytes

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2
Q

Due to defect in melanosomes dis?

A

1) tanning

2) nevus acromicus

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3
Q

Due to defect in melanogenesis dis?

A

1) melasma
2) freckles
3) albinism

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4
Q

Skin lesion in peutz jeughers?

A

Perioral lentigens

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5
Q

xeroderma pogmentosum, due to defect in?

A

DNA repair mechanism where nucleotide excision repair defect

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6
Q

Skin lesion in xeroderma pigmentosum?

A

1) Freckles

2) squamous cell ca

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7
Q

Ceruloderma due to defect in?

A

Defective migration of melanocytes to stratum Basale

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8
Q

Melanocytes derives from?

A

Neural crest cells

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9
Q

Merkel cells location?

A

In rete ridges in stratum basale

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10
Q

Langerhan cells present in

A

Stratum spinosum

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11
Q

Granules in langerhan cells

A

Birbeck granules - racquet shapes granules

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12
Q

Langerhan cells immunohistochemistry?

A

Positive for CD1a, CD207 (langerin), S100

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13
Q

Langerhan cells dec in

A

1) psoriasis

2) sarcoidosis

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14
Q

Langerhan cells inc in

A

Langerhan cell histiocytosis (LHC) or histiocytosis X

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15
Q

Types of LHC

A

1) eosinophilic granuloma
2) hand schuller Christian dis
3) Literer siwe dis
4) hashimoto pritzker dis

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16
Q

Lesions in eosinophilic granuloma?

A

Osteolytic lesions on temporoparietal skull

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17
Q

Triad in hand schuller Christian dis?

A

1) multiple bone defects
2) di
3) exophthalmos/ proptosis

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18
Q

Literer siwe dis clinical features?

A

1) Seborrhic dermatitis over
- scalp
- t zone
- nasolabial folds
- retroauricular area
- presternal area
- interscapular area
2) bone inv
3) hepatosplenomegaly
4) lymphadenopathy

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19
Q

LHC Age wise dis ?

A

Eosinophilic granuloma- <8y
Hand schuller Christian dis - <5y
Literer siwe dis- <2y
Hashimoto pritzker dis - since birth

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20
Q

Derivatives of cells of epidermis?

A

1) keratinocytes- ectoderm
2) melanocytes - neural crest cells
3) merkel cells - ectoderm>neural crest cell
4) langerhan cells - bone marrow

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21
Q

Epidermal turnover time?

A

52-75days (14+14+28)

22
Q

Epidermal turnover time dec in?

A

Psoriasis (4days)

23
Q

Desmosomes made of?

A

Desmosomal protein cld calcium dependant desmosomal Adhesion molecule

24
Q

Desmosomal protein belong to 3 types of gene family?

A

1) cadherin
2) plakin
3) armadillo

25
Types of desmosomal protein?
1) desmoglein 2) desmocolin 3) desmoplakin 4) plakoglobin
26
Granules in str granulosum?
Keratohyaline granules which synthesise filaggrin
27
Membrane coating granules are cld
Odland bodies
28
Odland bodies fncn
To syn lipid memb
29
Due to def str granulosum dis?
1) icthyosis vulgaris (autosomal dominant) Due to def fliaggrin 2) asteototic eczema (due to old age or cold)
30
Str lucidum translucent due to?
Elaidin refractive protein
31
Str lucidum present in?
Palms and soles
32
Parakeratosis seen in? (Presence of nucleus in str corneum)
1) psoriasis 2) eczema 3) actinic keratosis 4) seborrhic dermatitis 5) sq cell CA
33
Dyskeratosis seen in?
1) sq cell CA 2) Bowen dis 3) pagets dis 4) hailey hailey dis 5) darrier dis
34
In acute eczema, histology seen is?
Spongiosis and ballooning
35
In chronic eczema, histologic feature seen is?
Acanthosis
36
Regular acanthosis in?
Psoriasis | Chronic eczema
37
Irregular ancanthosis in
Lichen planus
38
Histology in lichen planus?
Irregular acanthosis | Hypergranulosis
39
Histologic feature in psoriasis
Angranulosis | Regular acanthosis
40
Neutrophilic microabsecc in
Cld papillary tip microabscess seen in dermatitis herpetiformis
41
In psoriasis, microabscess seen?
Munro microabscess | Kogoj pustules
42
Lymphocytic microabscess in
Also cld pautrier m/a seen in mycosis fungoides
43
Eosinophilic microabscess in?
Also cld intraepidermal eosinophilic m/a seen in pemphigus vegetans
44
Defect in BPAG1/BP230 Lead to?
- bullous pemphigoid | - dermatitis herpetiformis
45
Defect in BPAG2/BP180 lead to?
- Bullous pemphigoid - herpes gestationalis - linear IgA dis - lichen planus pemphigoides
46
Defect in collagen 7 lead to?
Epidermolysis bullosa dystrophicans
47
Collagen in dermis?
Type 1 and type 3
48
Str corneum becomes in preterm develops within?
2-3 weeks postnatal
49
Malpighian layer of epidermis?
Str basale + str spinosum
50
Integumentary system has?
``` Skin Hair Nails Glands Subcutaneous tissue ```
51
Mutations in desmosomes are the main cause of
Arrythmogenic right ventricular cardiomyopathy

Derma (6 decks)

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