General

Question 1

Alpha1 receptors

Answer 1

activation of receptors increases DAG and IP3—-> INCREASED CALCIUM LEVELS

postsynaptic
engage in downstream signaling

Question 2

alpha2 receptors

Answer 2

activation of receptor decreases cAMP production…inhibition of further release of NE

located presynaptically
function as autoreceptors

Question 3

alpha1 subtypes

Answer 3

1a
1b
1d

Question 4

alpha1 receptors involved in…

Answer 4

smooth muscle contraction

Question 5

alpha1 subtypes explains why…

Answer 5

drugs show preference based on anatomical locations

Question 6

a-blocker…MAIN adverse effect

Answer 6

first dose orthostatic hypotension!!!!!

most prominant w/ prazosin
not correlated w/ serum level
reduced dose, take w/ food and before bed

Question 7

Why do a-blockers cause orthostatic hypotension?

Answer 7

1. too rapid reduction of BP
2. effect of drugs on a2 receptors
   (increased release of NE…tachycardia)

Question 8

a-blocker adverse effects

Answer 8

first dose orthostatic hypotension

sinus-tach (angina, palpitations), syncope, vertigo (b.c a2 receptors blocked…inc NE release)