General Adult Flashcards
(44 cards)
Genetic risk of schizophrenia
Population risk - 1%
Grandchildren - 5%
Half-sibling - 6%
Full sibling - 9%
Child - 13%
Fraternal twin - 17%
Child (dual mating) - 46%
Identical twin - 48%
Risk of pueperal psychosis
Baseline risk - 1-2/1000
BPAD - 50%
Subsequent pregnancies 50-80%
OCD (history)
HPC (onset and duration)
Elicit core Sx (origin, nature, obsessions, compulsions)
Impact on functioning
Risk assessment (self, others, children)
Comorbidity (mood, enjoyment, sleep, appetite, hallucinations, delusions, passivity)
Substance use
Psychosis (MSE)
Core delusional belief (evidence, challenge)
Other delusions (persecution, grandiose, reference)
Hallucinations (auditory and other modalities)
Thought interference
Passivity experiences
Impact on mood
Substances
Risk
Questions about auditory hallucinations
Do you hear sounds or voices that others cannot?
How many voices?
Are they as clear as me speaking to you now?
What do they say?
Do they speak to you or about you or both?
Do they give you instructions or commands?
Do they comment on your actions?
How do you feel about them?
Could there be any alternative explanation?
Questions about non-auditory hallucinations
Has there been anything wrong with your sense of smell recently?
Have you noticed that food or drink tastes differently to normal? Strange taste in your mouth at other times?
Have you had any strange feelings in your body?
Have you been able to see things that others cannot? What kinds of things do you see?
Questions about thought interference
Do you feel that somebody is interfering with your thoughts? Who?
Do you ever feel that you have thoughts in your head that are not your own? Where do you think these come from?
Do you ever feel that other people can know what you are thinking?
Do you ever feel as though thoughts are being removed from your head?
Mania (history)
HPC (onset, duration)
Core mania symptoms (elation, irritability, energy, sleep, appetite, racing thoughts)
Grandiose delusions
Hallucinations (all modalities)
Thought interference and passivity
Risk (Police, spending, substances, promiscuity, self, others)
Delirium Tremens (history)
HPC (onset, duration)
Visual hallucinations (content, clarity, alternative explanation)
Hallucinations in other modalities
Orientation (time, place, person)
Alcohol history (quantity, duration, last drink, withdrawal, prev abstinence)
Risk (self, others)
Panic disorder (history)
HPC (onset, duration, first episode, frequency, triggers)
Physical symptoms
Psychological symptoms
DDx (generalised anxiety, social anxiety, phobia, OCD, PTSD, depression)
Impact on life and coping strategies
PPHx, FHx, brief PHx, PMHx, medications
Pass review (MSE)
Reason for admission and change since then
Auditory hallucinations
Delusional beliefs
Thought interference and passivity experiences
Mood (sleep, appetite, enjoyment)
Insight (understanding, medication)
Risk (plans at home, self, others, plan to return)
Psychotic depression (history)
HPC (onset, duration)
Nihilistic delusions (challenge these)
“How were things for you before you died”
Mood (sleep, appetite, enjoyment, energy, future)
Other psychotic symptoms
Risk
Adult ADHD (history)
Core features (hyperactivity, inattention, impulsiveness)
Impact on functioning (work, leisure, relationships, Police)
Childhood history (childhood symptoms, academic attainment, previous treatments, comorbid disorders)
Mood and substances
Risk (violence, impulsivity, driving)
Address other concerns
Panic disorder (explanation)
Clarify diagnosis and explain symptoms
Explain aetiology (stressors, FHx, personality)
Pharmalogical treatment
Psychological treatment (CBT)
Other concerns and leaflets
Hyperprolactinaemia (explanation)
Explain result and cause
Elicit symptoms (abnormal periods, breast changes, sexual dysfunction, fractures)
Screen for pituitory tumor (headaches, blurred vision, weakness, numbness)
Explain long-term side-effects (osteoporosis, risk of breast cancer)
Options for management (change antipsychotic, add aripiprazole)
Clozapine (explanation)
Clarify rationale and response rate (60%)
Explain side-effects
Explain monitoring (bloods - initially weekly, obs, ECG)
Missed doses (as soon as remembers, unless 4hours until next dose, retitrate if >48hrs)
Smoking and alcohol
Other concerns and leaflet
Lithium augmentation (explanation)
Lithium use: prophylactic in bipolar - ‘mood stabliser’.
Augement for treatment reistant depression.
Lowers risk of suicide.
Proven with scientific study - however unclear on how it works.
Interacts with ACE-I, diuretics, NSAIDS.
Risk of dehydration
Risk of damage to thyroid and kidneys.
Can exaccerbate acne and psoriasis.
Pregnancy: Used in caution due to teratogenic risks.
Baseline bloods: FBC, U+E, TFT, ECG, Calcium.
Monitoring is weekly until steady state. Lithium levels 3 monthly. TFTs U+Es 6 monthly. Annually BMI (risk of weight gain).
Narrow therapeutic window.
Side effects:
Increased thirst, fine tremor, weight gain.
Long term: Nephrotoxic, thyroid/parathyroid.
Signs of toxicity - Diarrhoea, coarse tremor, confusion, neurological symptoms, coma.
Discontinuation may lead to relapse.
ECT (explanation)
Medically induced seizure
Life threatening depression - requiring urgent treatment
6-12 sessions 2 x per week
Amnesia around event. Headache. Disorientation:
Rarer and longer term - more persistent memory loss -typically - autobiographical memory loss.
Supervision of anaethetist - risk of anaesthetic 1:100000
Can return home or to ward, will need adequate support around this.
Not like media. It is painless, controlled.
Relapses can be common, may need further ECT sessions/other treatments.
Schizophrenia (explanation)
Type of psychotic disorder
Severe mental illness - often misrepresentated
+ve symptoms:
Hearing/seeing./feeling/smelling things that are not there (hallucinations)
Unshakable belief something that is objectively untrue (delusion)
Confused/muddled thoughts (thought disorder).
-ve symptoms:
similar to depression
Social isolation
anhedonia
Self-neglect
Loss of motivation.
-ve often develop for years - prodromal stage. Missed diagnosis ie depression.
Psyhotic - for acute +ve symptoms.
Genetics, enviromental (drugs/ trauma),
Antipsychotics mainstay treatment. CBT P also helpful. Chronic, relapsing emiting
Schizophrenia (Hx from CPN)
Timecourse
Fluctuations in symptoms
Thought interference:
Insertion, withdrawal, broadcast.
Auditory hallucinations: commentary, arguing, thought echo.
‘Made’ experiences (created externally).
Passivity phenomena (physical sensations felt coming into body from external).
Delusional perception: Real perception lead to sudden strong belief with no relation to initial experience.
Screen -ve symptoms
MHx and Drug Hx.
Assess functioning.
FHx.
Rule out mood disturbance, other psychotic illness, ?relapse
Bipolar disorder (explanation)
mental health disorder that is
characterised by severe shifts in mood state that can affect energy, thinking, behaviou, risk and sleep.
Chronic disorder. Typically involving relapses - periods stability followed by mania/depression
Mania: excited, happy, energetic, irritable, hypersexual, risk taking, aggression, less sleep, racing thoguhts, over confidence.
Depression: low mood, anhedonia, anergia, poor sleep/over sleep, poor ocncentration, social isolation, suicidal thoughts.
Hypomania: Less than week, less intesne symptoms.
Can be associated with psychosis - loss of touch with reality, delusions such as grandiosity in mania, or belief that dead when depressed - mood congruent + hallucinations.
1-3% affected. Delay in diagnosis.
Mood stablisers mainstay Tx. Many types.
Lithium in pregnancy (explanation)
Teratogenic - risk of ebsteins anomoly (heart defect - tricuspid valve abnormality). Small increase in risk (found in some studies)
1:20,000 base risk. 1:1000 if on Li.
General risks: Insufficient evidence if Li causes miscarriage, stillbirth, low birth weight.
Evidence of reduced muscle tone, issues feeding, sedation.
Alternative options:
Can swap to antipsychotic (quetiapine)
If well/stable, can consider no medication - but HIGH risk of relapse due to incr risk secondary to mania.
Can consider continuing Lithium - accepting risk of teratogenicity - as changes in physiology during pregnancy.
Lithium levels tend to DECREASE - dose need to INCREASE.
After birth - this is reversed.
During: 4 weekly blood tests - at 36 weeks, weekly.
No impact on conception
Lithium not whilst breast feeding.
Treatment-resistant Depression (treatment)
ECT
Combination therapy - SSRI + mirtazapine or venlafaxine and mirtazapine.
Use of antipsychotic adjunct
Use of lithium adjunct
Utilising psychological therapies in combination.
Ongoing research into new medications such as Esketamine spray
OCD (explain medications)
SSRI’s used - often high doses.
Clomipramine - Can be added
Antipsychotic medications can be used second lien.
Combination with therapy ERP best.