General and Receptor locations and effects

Question 1

alpha1 adrenergic responses

Answer 1

Gq–>cGMP–>PLC–>IP3 and DAG–> Calcium

Blood Vessels
vasoconstriction

Question 2

Central alpha2a adrenergic

Answer 2

Gi–>block adenylate cyclase–>decrease cAMP

inhibit vasomotor center (RVLM)
decrease sympathetic outflow

Question 3

beta adrenergic responses

Answer 3

Gs–>cGMP–>adenylate cyclase–>cAMP——–>protein kinase activation–>enzyme-PO4——->biological effect

(cAMP)

Heart

Question 4

NE—->B1 receptors (heart)

Answer 4

stimulatory

Major

Question 5

NE—->B2 receptors (heart)

Answer 5

stimulatory

Minor

Question 6

NE—->a1 receptors (heart)

Answer 6

stimulatory

Minor

Question 7

ACh—->M2 (heart)

Answer 7

inhibitory

Question 8

NE—->a2 (sympathetic nerve terminal)

Answer 8

inhibitory

Question 9

ACh—->a2 (sympathetic nerve terminal)

Answer 9

inhibitory

Question 10

NE—–>b2 (sympathetic nerve terminal)

Answer 10

stimulatory

Question 11

NE—–>a2 (blood vessel)

Answer 11

vasoconstriction

Minor

Question 12

NE——->a1 (blood vessel)

Answer 12

vasoconstriction

Major

Question 13

NE——>b2 (blood vessel)

Answer 13

vasodilation

Minor

Question 14

ACh——>M2 (blood vessel)

Answer 14

vasodilation

Question 15

Release ACh

Answer 15

Parasympathetic nerve terminal

Sympathetic Cholinergic nerve terminal

Question 16

Release NE

Answer 16

Most postganglionic sympathetics

Question 17

Release Epinephrine

Answer 17

Adrenal medulla