General Immuno

Question 1

Dendritic cell role and location

Answer 1

Skin, mucosa, lymphoid tissue
Process antigens and present them to T cells, create cytokines,

Question 2

Monocyte function

Answer 2

INNATE IMMUNE RESPONSE, Largest WBC, produced in bone marrow, can differentiate into macrophages and dendritic cells.

Question 3

Macrophage function

Answer 3

Innate and adaptive responses, release cytokines, engulf and digest organisms, process antigens and present them to T lymphocytes

Question 4

Enzyme required for generation of NADPH in pentose pathway for oxidation of ROS (glutathione)

Answer 4

Glucose-6-dehydrogenase

Question 5

Substrates of purine synthesis

Answer 5

Aspartate, glutamine, glycine, and carbons from 1C metabolism

Question 6

Pyramidines

Answer 6

Thymine, cytosine, uracil

Question 7

Purines

Answer 7

Adenine, guanine

Question 8

Adaptive immunity cells

Answer 8

T cells, B cells, circulating ABs

Question 9

Innate immune cells

Answer 9

Neutrophils, macrophages, monocytes, dendritic cells, NK cells, complement.

Question 10

Innate immunity proteins and pathogen recognizition

Answer 10

TLRs, lysozymes, complement, CRP, defensins, cytokines

Question 11

Adaptive immunity proteins and pathogen recognition

Answer 11

Immunoglobulins, cytokines, memory cells (activated B and T cells)

Question 12

MHC 1

Answer 12

TCR and CD8, 1 long and 1 short chain

Question 13

MHC 2

Answer 13

TCR and CD4, 2 equal length chains

Question 14

HLC B27 diseases

Answer 14

Psoriatic arthritis, ankylosis spondylitis, IBD arthritis, reactive arthritis

Question 15

HLC DQ2/8 diseases

Answer 15

Celiac disease

Question 16

HLC DR3 diseases

Answer 16

DM1, SLE, Graves disease, Hashimotos, Addison disease

Question 17

HLC DR4 diseases

Answer 17

Rheumatoid arthritis, DM1, Addison disease

Question 18

NK Cells

Answer 18

Lymphocyte, innate immune system, Perforin and granzymes to induce apoptosis

Question 19

B Cells

Answer 19

Humoral immunity, recognize and present antigen, produce AB, maintain immunologic memory

Question 20

T Cells

Answer 20

Cell mediated immunity, CD4 and CD8, type IV hypersensitivity

Question 21

Type 1 hypersensitivity rxn

Answer 21

Immediate allergy response (anaphylaxis, allergic asthma), IgE mediated

Question 22

Type 2 hypersensitivity rxn

Answer 22

IgG mediated, cell destruction, inflammation, cellular dysfunction, myasthenia gravis/ good pastures/ AI hemolytic anemia/ rheumatic fever

Question 23

Type 3 hypersensitivity rxn

Answer 23

Ag-Ab IgG complexes that attract neutrophils and release lysosomal enzymes, SLE/ RA/reactive arthritis/ PSGN/ IgA vasculitis

Question 24

Type 4 hypersensitivity rxn

Answer 24

Delayed, no AB involvement, direct cell cytotoxicity or inflammatory rxn, contact dermatitis

Question 25

IL-1

Answer 25

Fever, acute inflam, activates endothelial adhesion molecules, induces chemokine recruitment of WBCs

Question 26

IL-6

Answer 26

Fever, stimulates acute phase proteins (CRP, ESR)

Question 27

TNF-alpha

Answer 27

Activates endothelium, causes WBC recruitment, leads to vascular leaks

Question 28

IL-8

Answer 28

Chemotactic factor for neutrophils

Question 29

IL-12

Answer 29

Induces differentiation of T cells into Th1 cells, activates NK cells

Question 30

Secreted by macrophages

Answer 30

IL1/6/8/12, TNF-alpha

Question 31

Secreted by T cells

Answer 31

IL2&3

Question 32

Secreted by Th1

Answer 32

Interferon-gamma

Question 33

Secreted by Th2

Answer 33

IL-4/5/10/13