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Neoplasia > General Neoplasia > Flashcards

General Neoplasia Flashcards

(80 cards)

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1
Q

Down’s

A

ALL,AML

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2
Q

Xeroderma pigmentosum, albinism

A

Melanoma, basal cell carcinoma, and especially squamous cell carcinoma of skin

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3
Q

Chronic atrophic gastritis, pernicious anemia, post surgical gastric remnants

A

Gastric adenocarcinoma

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4
Q

Tuberous sclerosis (facial angiofibroma, seizures, mental retardation

A

Giant Cell astrocytoma, renal angiomyolipoma, and cardiac rhabdomyoma

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5
Q

Actinic keratosis

A

squamous cell carcinoma of skin

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6
Q

Barrett’s esophagus (chronic GI reflux)

A

esophageal adenocarcinoma

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7
Q

Plummer-Vinson syndrome (decreased iron)

A

Squamous cell carcinoma of esohagus

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8
Q

Cirrhosis (alcoholic, HepB or C)

A

Hepatocellular carcinoma

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9
Q

Ulcerative collitis

A

Colonic adenocarcinoma

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10
Q

Paget’s disease of bone

A

secondary osteosarcoma and fibrosarcoma

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11
Q

Immunodeficiency states

A

Malignant lymphomas

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12
Q

AIDS

A

Aggressive malignant lymphomas (non-Hodgkin’s) and Kaposi’s sarcoma

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13
Q

Autoimmune disease (Hashimoto’s thyroiditis, maysthenia gravis)

A

Lymphoma

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14
Q

Acanthosis nigricans (hyperpigmentation and epidermal thickening)

A

Visceral malignancy (stomach, lung, uterus)

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15
Q

Dysplastic nevus

A

Malignant melanoma

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16
Q

Radiation exposure

A

Leukemia, sarcoma, papillary thyroid cancer, breast cancer

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17
Q

abl

A

CML, tyrosine kinase; OG

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18
Q

c-myc

A

Burkitt’s lymphoma, transcription factor; OG

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19
Q

bcl-2

A

Follicular and undifferentiated lymphomas, anti-apoptosis; OG

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20
Q

HER2/neu (c-erbB2)

A

Breast, ovarian, and gastric carcinomas, tyrosine kinase; OG

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21
Q

ras

A

Colon cancer, GTPase; OG

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22
Q

L-myc

A

Lung tumor, transcription factor; OG

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23
Q

N-myc

A

Neuroblastoma, trasncription factor; OG

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24
Q

ret

A

MEN 2A and 2B, Tyrosine kinase; OG

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25
c-kit
GIST, cytokine receptor; OG
26
Rb
TS; retinoblastoma, osteosarcoma: inhibits E2F and blocks G1 to S
27
p53
TS; most cancers, Li Fraumeni: trasncription factor for p21 and blocks G1 to S
28
BRCA1
TS; breast and ovarian: DNA repair protein
29
BRCA2
TS; breast and ovarian: DNA repair protein
30
p16
TS; melanoma
31
BRAF
TS; melanoma: B-raf
32
APC
TS; colorectal cancer (associated with FAP)
33
WT1
TS; Willms' Tumor (nephroblastoma)
34
NF-1
TS; NeuroFibromatosis type 1: RAS GTPase activating proten (RAS-GAP)
35
NF-2
TS; NeuroFibromatosis type 2: Merlin (schwannomin) protein
36
DPC4
TS; Pancreatic Cancer (Deleted in Pancreatic Cancer)
37
DCC
TS; Colon cancer (Deleted in Colon Cancer)
38
PSA
use to follow prostate cancer
39
Prostatic acid phosphatase
prostate carcinoma
40
CEA
CarcinoEmbryonicAntigen, nonspecific. Produced by 70% of colorectal and pancreas cancers. Also gastric, breast, medullary thyroid carcinomas
41
alpha-fetoprotein
fetal albumin. Hepatocellular carcinoma, nonseminomatos germcell tumors
42
beta-hCG
Hydatidifrom moles, choriocarcinomas (gestational trophoblastic disease)
43
CA-125
ovarian cancer
44
S-100
melanoma, neural tumors, schwannomas
45
AlkPhos
mets to bone, liver, or Paget's of bone
46
Bombesin
Neuroblastoma, lung, gastric cancer
47
TRAP
Hairy Cell leukemia (a B-cell neoplasm)
48
CA-19-9
Pancreatic adenocarcinoma
49
Calcitonin
Medullary thyroid carcinoma
50
HTLV-1
Adult T-cell leukemia/lymphoma
51
HBV, HCV
Hepatocellular carcinoma
52
EBV
Burkitt's Hodgkin's, nasopharyngeal carcinoma (China), CNS lymphoma (immune compromise)
53
HPV
cervical (16,18) penile/anal, upper respiratory SCC
54
HHV-8
Kaposi's, body cavity fluid B-cell lymphoma
55
H. pylori
GASTRIC adenocarcinoma and lymphoma
56
Schistosoma heamatobium
bladder cancer
57
Clonorchis sinensis
cholangiocarcinoma
58
Aflatoxins (aspergillus)
Hepatocellular carcinoma
59
Vinyl chloride
Liver angiosarcoma
60
Carbon tetrachloride
Liver centrolobular necrosis, fatty change
61
Nitrosamines (smoked food)
Gastric cancer
62
Cigarette smoke
SCC of larynx and lung, small cell of lung, renal cell carcinoma, transitional cell carcinoma, pancreatic adenocarcinoma
63
Asbestos
Bronchogenic carcinoma > mesothelioma
64
Arsenic
SCC of skin, Angiosarc of liver
65
Naphthaline (analine dyes)
Transitional cell carcinoma
66
Alkylating agents
Leukemia
67
Cushing's syndrome
ACTH or ACTH-like peptide, Small Cell Lung Cancer
68
SIADH
ADH, Small Cell lung cancer and intracranial neoplasms
69
PTHrP
Hypercalcemia, squamous of lung, renal cell, breast
70
1,25-(OH)2 D3
Hypercalcemia:Hodgkin's lymphoma, some non-Hodgkin's lymphoma
71
EPO
polycythemia: renal cell, hemangioblastoma, hepatocellular, pheo
72
Lambert-Eaton syndrome (muscle weakness)
Ab anti- presynaptic Ca++ channels at NMJ: Small Cell Lung cancer
73
Psammoma bodies
Papillary (thyroid), Serous (ovary), Meningioma, Mesothelioma
74
Top 3 Male incidence
Prostate, Lung, Colon
75
Top 3 Female incidence
Breast, Lung, Colon
76
Top 2 Mortality Male
Lung, Prostate
77
Top 2 Mortality Female
Lung, Breast
78
Mets to brain
Lung>breast>GU>osteosarc>melanoma>GI
79
Mets to Liver
Colon>>stomach>pancreas
80
Mets to bone
prostate/breast>lung>thyroid,testes

Neoplasia (1 decks)

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