General Pharma Flashcards by Shanzay A

Clearance Formula

Vd x Ke (elimination constant)

0.7 x Vd)/(T-half

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In first order kinetic (constant rate).. how long to steady state?

4-5 half-lives.

3.3 half-lives to reach 90% SS

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Tachyphylactic Drugs

Decrease response after initial admin

Nitrates, Niacin, Phenylephrine, LSD, MDMA

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Zero Order Elimination Drugs

Phenytoin
Ethanol
Aspirin (high conc)

Constant amount eliminated per unit time

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First Order

Constant Fraction eliminated per unit time

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Weak Acids

Phenobarbital
MTX
Aspirin(Salicylates)

Tx Sodium Bicard to Alkalize Urine

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Weak Base

TCA, Amphetamine

Tx Ammonium Cl to acidify urine

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Permissive

Cortisol on Catecholamines (NE, Epi)

Presence of Cortisol (A) required for full effect of NE & E (B)

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Torsades de Pointes

Anti Arrythmics (IA &amp; III)
Anti Biotics (Marcolides) eg Erythromicin
Anti PsyChotics (Haloperidol)
Anti Depressants (TCA)
Anti Emetics (Odansetron)

Prolongs QT Interval

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Coronary Vasospasm

Cocaine
AmphetamineSumatriptan
Ergot Alkaloids

(CASE)

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DCM

Anthracyclines like Doxorubicin, Daunorubicin

TX Dexrazoxane

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Lithium, Demeclocycline

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SIADH

Carbamezapine, Cyclophosphamide, SSRIs

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Acute Cholestatic Hepatitis, Jaundice

Macrolides like Erthromycin

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DRESS- DELAYED HS. 2-8 WEEKS

DRUG RXN WITH EOSINOPHILIA & SYST SS

Allopurinol
AntiConvulsants
AntiBiotics
Sulfa Drugs

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Gray Baby Syndrome

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Chloramphenicol

Thrombocytopenia

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Heparin
Vancomycin
Linezolid

Photosensitivity

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Sulfonamides
Amiodarone
Tetracyclines
5FU

Idiopathic Intracranial HTN

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GH
Tetracyclines
Vitamin A

Hemorrhagic Cystitis

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Prevent with Mesna

Cyclophosphamide
Isofamide

Interstitial Nephritis

"”5P’s”

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Diuretics (Pee)
NSAIDS (Pain-Free)
Penicillins and Cephalosporins
PPIs
rifamPicin
SulPha drugs

Dry Cough

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ACEI

Pulm Fibrosis

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MTX
Nitrofurantoin
Carmustine
Bleomycin
Busulfan
Amiodarone

Anti Muscaranic (NO SECRETIONS)

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Atropine
TCA
H1 Blockers
AntiPsychotics

Cisplatin (Ototoxic/Nephrotoxic)

May respond to | Amifostine

General Pharma Flashcards

(25 cards)