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FA Points > General Pharma > Flashcards

General Pharma Flashcards

1
Q

Clearance Formula

A

Vd x Ke (elimination constant)

0.7 x Vd)/(T-half

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2
Q

In first order kinetic (constant rate).. how long to steady state?

A

4-5 half-lives.

3.3 half-lives to reach 90% SS

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3
Q

Tachyphylactic Drugs

A

Decrease response after initial admin

Nitrates, Niacin, Phenylephrine, LSD, MDMA

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4
Q

Zero Order Elimination Drugs

A

Phenytoin
Ethanol
Aspirin (high conc)

Constant amount eliminated per unit time

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5
Q

First Order

A

Constant Fraction eliminated per unit time

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6
Q

Weak Acids

A

Phenobarbital
MTX
Aspirin(Salicylates)

Tx Sodium Bicard to Alkalize Urine

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7
Q

Weak Base

A

TCA, Amphetamine

Tx Ammonium Cl to acidify urine

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8
Q

Permissive

A

Cortisol on Catecholamines (NE, Epi)

Presence of Cortisol (A) required for full effect of NE & E (B)

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9
Q

Torsades de Pointes

A 
Anti Arrythmics (IA & III)
Anti Biotics (Marcolides) eg Erythromicin
Anti PsyChotics (Haloperidol)
Anti Depressants (TCA)
Anti Emetics (Odansetron)

Prolongs QT Interval

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10
Q

Coronary Vasospasm

A

Cocaine
AmphetamineSumatriptan
Ergot Alkaloids

(CASE)

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11
Q

DCM

A

Anthracyclines like Doxorubicin, Daunorubicin

TX Dexrazoxane

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12
Q

DI

A

Lithium, Demeclocycline

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13
Q

SIADH

A

Carbamezapine, Cyclophosphamide, SSRIs

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14
Q

Acute Cholestatic Hepatitis, Jaundice

A

Macrolides like Erthromycin

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15
Q

DRESS- DELAYED HS. 2-8 WEEKS

DRUG RXN WITH EOSINOPHILIA & SYST SS

A

Allopurinol
AntiConvulsants
AntiBiotics
Sulfa Drugs

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16
Q

Gray Baby Syndrome

A

Chloramphenicol

17
Q

Thrombocytopenia

A

Heparin
Vancomycin
Linezolid

18
Q

Photosensitivity

A

Sulfonamides
Amiodarone
Tetracyclines
5FU

19
Q

Idiopathic Intracranial HTN

A

GH
Tetracyclines
Vitamin A

20
Q

Hemorrhagic Cystitis

A

Prevent with Mesna

Cyclophosphamide
Isofamide

21
Q

Interstitial Nephritis

"”5P’s”

A 
Diuretics (Pee)
NSAIDS (Pain-Free)
Penicillins and Cephalosporins
PPIs
rifamPicin
SulPha drugs
22
Q

Dry Cough

A

ACEI

23
Q

Pulm Fibrosis

A 
MTX
Nitrofurantoin
Carmustine
Bleomycin
Busulfan
Amiodarone
24
Q

Anti Muscaranic (NO SECRETIONS)

A

Atropine
TCA
H1 Blockers
AntiPsychotics

25
Q

Cisplatin (Ototoxic/Nephrotoxic)

A

May respond to

Amifostine

FA Points (1 decks)

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