Generalized Anxiety Disorder Flashcards

(111 cards)

1
Q

What is generalized anxiety disorder (GAD)?

A

Excessive and persistent worrying that is hard to control, causes significant distress or impairment, and occurs on more days than not for at least six months.

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2
Q

What are common predictors (risk factors) of incident GAD?

A
  • Female sex
  • Poverty
  • Recent adverse life events
  • Unmarried status
  • Chronic physical illness (respiratory, cardiovascular, metabolic, cognitive)
  • Chronic mental disorder (depression, phobia, past GAD)
  • Parental loss or separation
  • Low affective support during childhood
  • History of mental problems in parents
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3
Q

What screening tool is used for generalized anxiety disorder?

A

The generalized anxiety disorder seven-item (GAD-7) scale.

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4
Q

What is the significance of a GAD-7 score of 10 or more?

A

It has good diagnostic sensitivity and specificity.

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5
Q

How are greater GAD-7 scores related to functional impairment?

A

Greater GAD-7 scores correlate with more functional impairment.

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6
Q

On what criteria was the GAD-7 scale developed and validated?

A

Based on DSM-IV criteria.

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7
Q

How often have you been bothered by feeling nervous, anxious, or on edge? (GAD-7)

A

Respond with: Not at all, Several days, More than half the days, Nearly every day.

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8
Q

What is the total score range for the GAD-7?

A

0 to 21.

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9
Q

What do scores of 5, 10, and 15 represent in the GAD-7?

A
  • 5 - Mild anxiety
  • 10 - Moderate anxiety
  • 15 - Severe anxiety
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10
Q

Does the GAD-7 have utility for disorders other than GAD?

A

Yes, it has moderately good operating characteristics for panic disorder, social anxiety disorder, and posttraumatic stress disorder.

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11
Q

What is the recommended cutoff for further evaluation when screening for anxiety disorders using the GAD-7?

A

A score of 10 or greater.

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12
Q
A
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13
Q

What is the primary characteristic of generalized anxiety disorder (GAD)?

A

Presence of generalized, persistent, and excessive anxiety.

GAD involves a combination of psychological and somatic complaints.

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14
Q

How long must excessive anxiety and worry occur to meet the DSM-5 criteria for GAD?

A

More days than not for at least six months.

This anxiety must be about a number of events or activities.

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15
Q

What does criterion B of the DSM-5 for GAD state?

A

Difficult to control the worry.

This reflects the uncontrollable nature of the anxiety experienced.

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16
Q

What are the six symptoms associated with anxiety and worry in GAD, represented by I CREST?

A
  • Restlessness or feeling keyed up or on edge (R)
  • Being easily fatigued or loss of energy (E)
  • Difficulty concentrating or mind going blank (C)
  • Irritability (I)
  • Muscle tension (T)
  • Sleep disturbance (S)

Only one symptom is required in children.

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17
Q

What is criterion D of the DSM-5 for GAD?

A

Causes clinically significant distress or impairment in social, occupational, or other important areas of functioning.

This highlights the impact of GAD on daily life.

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18
Q

What must be excluded to diagnose GAD according to criterion E?

A

Not attributable to the physiological effects of a substance or another medical condition.

Examples include drug abuse, hyperthyroidism, etc.

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19
Q

What does criterion F of the DSM-5 for GAD specify?

A

Not better explained by another mental disorder.

This ensures that GAD is diagnosed independently.

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20
Q

What are some clinical manifestations of GAD?

A
  • Difficulty relaxing
  • Headaches and pain in the neck, shoulders, and back
  • GIT symptoms

These manifestations can vary among individuals.

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21
Q

What percentage of individuals with current GAD had at least one concurrent disorder?

A

66%.

Common concurrent disorders include social phobia, panic disorder, and substance abuse.

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22
Q

What are some health risks associated with GAD?

A
  • Poor cardiovascular health
  • Coronary heart disease
  • Increased blood pressure

These risks highlight the physical health implications of GAD.

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23
Q

What medical conditions must be excluded when diagnosing GAD?

A
  • Endocrine conditions (e.g., hyperthyroidism)
  • Cardiopulmonary conditions (e.g., arrhythmia)
  • Neurologic diseases (e.g., temporal lobe epilepsy)
  • Other psychiatric disorders
  • Substance effects (e.g., caffeine)

This ensures that the symptoms are not due to other medical issues.

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24
Q
A
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25
What role does patient education play in anxiety treatment?
It can help reduce anxiety by identifying and removing possible triggers, improving sleep quality/quantity, and increasing physical activity. ## Footnote Triggers include caffeine, stimulants, nicotine, dietary factors, and stress.
26
What is the recommended exercise regimen for reducing anxiety?
Exercising at 60% to 90% of maximal heart rate for 20 minutes three times weekly. ## Footnote Yoga is also effective for anxiety reduction.
27
How long should SSRIs or SNRIs be continued for anxiety treatment?
At least 12 months rather than the standard 6 months. ## Footnote This duration helps limit relapse.
28
How should medications for anxiety be titrated?
Slowly, once every week or twice, and not considered ineffective until titrated to the high end of the dose range and continued for at least 4 weeks.
29
What should be done if there is no response after 4-6 weeks on maximum dose of an SRI?
The medication should be tapered off and another medication, typically a different SRI, should be considered.
30
What should patients who experience a partial response to an SRI receive?
Adjunctive treatment with one of the second-line medications or with cognitive behavioral therapy (CBT).
31
List common side effects (S/E) of anxiety medications.
* Sexual dysfunction * GI abnormalities (nausea and diarrhea) * Insomnia * Withdrawal on discontinuation * Drug interactions * Weight gain * Agitation and/or hyperactivation
32
What is the recommended duration for psychotherapy or CBT for GAD?
Weekly for at least 8 weeks to assess its effect. ## Footnote Can include 10 to 15 60-minute sessions, with additional sessions if necessary.
33
What is the impact of combined treatment with medications and psychotherapy?
It reduces relapse.
34
What are second-line treatment options for generalized anxiety disorder?
* Tricyclic antidepressants (ICAs) * Benzodiazepines (e.g., lorazepam 1 to 2 mg/day in divided doses) * Pregabalin * Buspiron
35
What are the limitations of benzodiazepines in anxiety treatment?
Dependence and tolerance have limited their use.
36
When might a psychiatric referral be indicated?
If there is poor response to treatment, atypical presentation, or concern for significant comorbid psychiatric illness.
37
What is the focus of pharmacology in treating adults with GAD?
Understanding the medications used for treatment.
38
What role does patient education play in anxiety treatment?
It can help reduce anxiety by identifying and removing possible triggers, improving sleep quality/quantity, and increasing physical activity. ## Footnote Triggers include caffeine, stimulants, nicotine, dietary factors, and stress.
39
What is the recommended exercise regimen for reducing anxiety?
Exercising at 60% to 90% of maximal heart rate for 20 minutes three times weekly. ## Footnote Yoga is also effective for anxiety reduction.
40
How long should SSRIs or SNRIs be continued for anxiety treatment?
At least 12 months rather than the standard 6 months. ## Footnote This duration helps limit relapse.
41
How should medications for anxiety be titrated?
Slowly, once every week or twice, and not considered ineffective until titrated to the high end of the dose range and continued for at least 4 weeks.
42
What should be done if there is no response after 4-6 weeks on maximum dose of an SRI?
The medication should be tapered off and another medication, typically a different SRI, should be considered.
43
What should patients who experience a partial response to an SRI receive?
Adjunctive treatment with one of the second-line medications or with cognitive behavioral therapy (CBT).
44
List common side effects (S/E) of anxiety medications.
* Sexual dysfunction * GI abnormalities (nausea and diarrhea) * Insomnia * Withdrawal on discontinuation * Drug interactions * Weight gain * Agitation and/or hyperactivation
45
What is the recommended duration for psychotherapy or CBT for GAD?
Weekly for at least 8 weeks to assess its effect. ## Footnote Can include 10 to 15 60-minute sessions, with additional sessions if necessary.
46
What is the impact of combined treatment with medications and psychotherapy?
It reduces relapse.
47
What are second-line treatment options for generalized anxiety disorder?
* Tricyclic antidepressants (ICAs) * Benzodiazepines (e.g., lorazepam 1 to 2 mg/day in divided doses) * Pregabalin * Buspiron
48
What are the limitations of benzodiazepines in anxiety treatment?
Dependence and tolerance have limited their use.
49
When might a psychiatric referral be indicated?
If there is poor response to treatment, atypical presentation, or concern for significant comorbid psychiatric illness.
50
What is the focus of pharmacology in treating adults with GAD?
Understanding the medications used for treatment.
51
52
What does SSRI stand for?
Selective Serotonin Reuptake Inhibitor
53
Name three SSRIs
* Citalopram * Escitalopram * Sertraline
54
What is the initial daily oral dose of Citalopram in mg?
10 mg
55
What is the initial daily oral dose range for Sertraline?
25 to 50 mg
56
What is the initial daily oral dose of Paroxetine in mg?
10 to 20 mg
57
What is the initial daily oral dose of Fluoxetine in mg?
10 to 60 mg in divided doses
58
What does SNRI stand for?
Serotonin-Norepinephrine Reuptake Inhibitor
59
Name two SNRIs
* Duloxetine * Venlafaxine (extended-release)
60
What is the initial daily oral dose of Duloxetine in mg?
30 mg
61
What is the daily oral dose range for Venlafaxine?
75 to 225 mg in divided doses
62
What is a characteristic of SSRIs relevant to GAD treatment?
Lower risk of insomnia/agitation
63
What is a common side effect associated with Paroxetine?
Greater risk of insomnia/agitation
64
What type of drug is Buspirone?
A nonbenzodiazepine anxiolytic
65
What is a key feature of Pregabalin?
A GABA analog calcium-channel modulator anticonvulsant
66
What is the initial daily oral dose of Mirtazapine?
15 mg
67
What is a potential side effect of Quetiapine?
Sedation, extrapyramidal effects, weight gain, and metabolic side effects
68
What is the initial daily oral dose of Imipramine in mg?
75 mg in divided doses
69
What is a notable risk of using tricyclic antidepressants?
Cardiotoxic in overdose
70
True or False: Withdrawal symptoms are present if Buspirone is not tapered.
False
71
Fill in the blank: Venlafaxine can lead to increased _______ and heart rate with increasing doses.
blood pressure
72
What is a characteristic of Duloxetine in relation to painful conditions?
Useful for treatment of comorbid painful conditions
73
What is a side effect associated with the use of SSRIs?
Can prolong QT interval with increasing blood levels
74
Fill in the blank: Mirtazapine is noted for being _______.
sedating
75
What is a common side effect of Fluoxetine?
Greater risk of insomnia/agitation
76
What is the initial daily oral dose of Quetiapine?
25 to 50 mg
77
What is the onset time for Pregabalin when starting treatment?
Onset within days of starting treatment
78
What is the maximum daily dose many patients require for Pregabalin?
Up to 300 mg/day
79
What is a major concern with the use of Quetiapine?
Rarely tardive dyskinesia
80
What is a significant characteristic of SNRIs?
Greater risk of gastrointestinal complaints
81
What is the classification of Imipramine?
A tricyclic antidepressant
82
What does SSRI stand for?
Selective Serotonin Reuptake Inhibitor
83
Name three SSRIs
* Citalopram * Escitalopram * Sertraline
84
What is the initial daily oral dose of Citalopram in mg?
10 mg
85
What is the initial daily oral dose range for Sertraline?
25 to 50 mg
86
What is the initial daily oral dose of Paroxetine in mg?
10 to 20 mg
87
What is the initial daily oral dose of Fluoxetine in mg?
10 to 60 mg in divided doses
88
What does SNRI stand for?
Serotonin-Norepinephrine Reuptake Inhibitor
89
Name two SNRIs
* Duloxetine * Venlafaxine (extended-release)
90
What is the initial daily oral dose of Duloxetine in mg?
30 mg
91
What is the daily oral dose range for Venlafaxine?
75 to 225 mg in divided doses
92
What is a characteristic of SSRIs relevant to GAD treatment?
Lower risk of insomnia/agitation
93
What is a common side effect associated with Paroxetine?
Greater risk of insomnia/agitation
94
What type of drug is Buspirone?
A nonbenzodiazepine anxiolytic
95
What is a key feature of Pregabalin?
A GABA analog calcium-channel modulator anticonvulsant
96
What is the initial daily oral dose of Mirtazapine?
15 mg
97
What is a potential side effect of Quetiapine?
Sedation, extrapyramidal effects, weight gain, and metabolic side effects
98
What is the initial daily oral dose of Imipramine in mg?
75 mg in divided doses
99
What is a notable risk of using tricyclic antidepressants?
Cardiotoxic in overdose
100
True or False: Withdrawal symptoms are present if Buspirone is not tapered.
False
101
Fill in the blank: Venlafaxine can lead to increased _______ and heart rate with increasing doses.
blood pressure
102
What is a characteristic of Duloxetine in relation to painful conditions?
Useful for treatment of comorbid painful conditions
103
What is a side effect associated with the use of SSRIs?
Can prolong QT interval with increasing blood levels
104
Fill in the blank: Mirtazapine is noted for being _______.
sedating
105
What is a common side effect of Fluoxetine?
Greater risk of insomnia/agitation
106
What is the initial daily oral dose of Quetiapine?
25 to 50 mg
107
What is the onset time for Pregabalin when starting treatment?
Onset within days of starting treatment
108
What is the maximum daily dose many patients require for Pregabalin?
Up to 300 mg/day
109
What is a major concern with the use of Quetiapine?
Rarely tardive dyskinesia
110
What is a significant characteristic of SNRIs?
Greater risk of gastrointestinal complaints
111
What is the classification of Imipramine?
A tricyclic antidepressant