Genetic risk of DO Flashcards
schizophrenia: population risk 1st degree relative risk if both parents have it risk of what other DO as well? heritability
1% 12% 47% schiz spectum schizoaffective depression 70-85%
Bipolar: population risk 1st degree relative risk if both parents have it risk of what other DO as well? heritability
0.6-1.8% (ot 1% of each type) 5-20% 50-75% depression schizoaffective cyclothymia ETOH
60-85%
genes involved: 5, 11, 18,21 X
MDD (men):
population risk
1st degree relative risk
risk of what other DO as well?
heritability
1-15%
9%
dysthymia
anxiety
ETOH
ADHD
40%
MDD (women):
population risk
1st degree relative risk
risk of what other DO as well?
heritability
2-25% 18% bipolar schizoaffective schizoprenia 40%
GAD, panic, OCD
prevalence
risk of first degree relative
heritability
1.5-3%
15-20%
40-50%
40-50% (60-7-% for OCD)
AN
BN
40-55% MZ, 11dz
35% MZ, 30 fx
Anorexia more than BN
Chance of sciz with velocardiofaciak
30%
Ocd
80-87% concordance in MZ
47-50% dZ
heritability is 60-70%
heritability of: ASD ADHD BAD schiz OCD ETOH AN Anx MDD
ASD: 90% ADHD: 60-90% schiz: 70-85% BAD: 60-85% OCD: 60-70% ETOH: 50-60% ED: 50-60% Anx: 40-50% (panic) MDD: 40%
Alcohol dehydrogenase gene
active allele protective
quickly turns alcohol to the toxic acetaldehyde
aldehyde dehydrogenase allele
inactive protective
accumulation of toxic acetaldehyde
D4 receptor gene
ADHD
MAOA
null allele impulsive aggresive
tryptophan hydroxylase
impulsivity
suicidality
MDD
BPD
5HT transporter (SCL6A4)
short allele neuroticism
ss> sl>ll in terms of depression in response to childhood maltreatment and number of stressful life events.
