Genetics Lecture 6 - Sequencing Techniques Flashcards
(6 cards)
1
Q
What does DNA Microarray highlight?
A
Deletions or insertions.
2
Q
What technique would you use to investigate a Dx of down syndrome?
A
Karyotype.
3
Q
Can sequencing pick up insertions or deletions?
A
No.
4
Q
Do microarrays give details regarding structure?
A
No, they would just show up as unhybridized and may be interpreted as a deletion.
5
Q
What is meant by “variance of unknown significance?”
A
Variances in SNPs may or may not be clinically significant.
6
Q
What does GWAS intend to solve? What is one major limitation?
A
Genome-wide association studies attempt to find correlation between specific SNPs and particular diseases. Large study groups are needed for the associations.
