Genito-urinary medicine Flashcards

(44 cards)

1
Q

Mechanism of action of contraception:

  • COCP
  • POP
  • Desogestrel
  • Implant
  • Depo provera
  • IUS
  • IUD
A

COCP: prevents ovulation, thickens cervical mucus and thins endometrium

POP: thickens cervical mucus, and alters endometrial lining

Desogestrel: inhibits ovulation and thickens cervical mucus

Implant: prevents ovulation, thickens cervical mucus

Depo provera: inhibits ovulations, thickens cervical mucus, thins endometrial lining

IUS: prevents endometrial proliferation and causes cervical mucus thickening

IUD: decreased sperm motility and survival

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2
Q

Advice on taking the COCP

A
  • If started on first 5 days of cycle, no additional contraception needed
  • If started at any other point, used additional contraception for 7 days
  • Take pill for 21 days and then stop for 7 (or use placebo for 7)
  • Reduced efficacy if vomited within 2 hours of taking pill, or if taking CYP450 inducers (PCBRAS)
  • Should be taken at the same time every day
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3
Q

Advised on missed COCP

A

1 missed pill at any point of cycle: take the missed pill even if it means taking two pills in one day. continue as normal, no additional contraception needed.

2+ pills missed:

  • take last missed pill even if it means taking 2 pills in one day, leave any earlier missed pills
  • Use condom until pill has been taken for 7 consecutive days
  • If pills are missed in days 1-7 of cycle: emergency contraception needed if unprotected sex occurred in pill-free week or in week 1
  • If pills are missed in days 8-14: take last missed pill even if it means taking 2 in one day, leave any earlier missed pills, use condom for 7 days, no emergency contraception needed
  • If pills are missed in days 15-21: finish current pack and start new pack, omitting the pill free week, no emergency contraception needed
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4
Q

COCP contraindications where disadvantages outweigh the advantages

A
>35y and smoking <15/day
BMI>35
FHx VTE in first degree relative <45y
BRCA1/2 carrier
Controlled HTN
Immobility

DM diagnosed >20yrs ago depending on severity

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5
Q

COCP contraindications carrying an unacceptable health risk

A
>35y smoking >15/day
Migraine with aura
Hx VTE
Current breast cancer
Uncontrolled HTN
Major surgery with prolonged immobilisation
Hx of IHD/stroke
Breast feeding <6wks post-partum

DM diagnosed >20yrs ago depending on severity

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6
Q

Pros vs cons of COCP

A

Pros:

  • failure rate 0.3% if used perfectly
  • doesnt interfere with sex
  • easily reversible
  • reduced risk of ovarian, endometrial and colorectal cancer
  • may protect from PID
  • makes periods lighter, regular and less painful
  • reduced incidence of acne, ovarian cysts and benign breast disease

Cons:

  • people may forget to take it
  • no STI protection
  • increased risk of VTE
  • increased risk of breast and cervical cancer
  • increased risk of stroke and IHD
  • headache, nausea, breast tenderness
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7
Q

Common adverse effect of POP

A

Irregular vaginal bleeding

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8
Q

Advice on taking POP

A
  • If started on days 1-5: no contraception needed
  • If started at any other time: contraception for 2 days
  • should be taken at the same time everyday without a pill free break
  • Most POPs have a 3 hour window every day where you have to take your pill
  • Desogestrel has a 12 hour window
  • If you have D+V then assume the pill has been missed and take action
  • CYP450 inducer reduce efficacy
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9
Q

Advice for missed POP

A

If missed but still within 3hours (<12hr if desogestrel) - continue as normal

If missed and >3hrs (>12hrs for desogestrel) - take missed pill ASAP, continue rest of pack as normal, use extra contraception for 48 hours

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10
Q

Advice on contraception following insertion of IUS

A

If inserted on days 1-7 of cycle: no additional contraception needed

If inserted at any other point of the cycle: extra protection for 7 days

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11
Q

Side effects and risks associated with IUS

A

Side effects: initial frequent uterine bleeding, but then usually people become amenorrhoeic or have intermittent light bleeding, with reduced dysmenorrhoea

Risks:

  • Uterine perforation
  • Small increased risk of PID in the first 20 days
  • Expulsion in the first 3 months
  • If you become pregnant, it is more likely to be ectopic (although absolute number of ectopics is reduced compared to population because there is a reduced number of pregnancies on IUS)
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12
Q

Indications and contraindications of IUS

A

Indications: first line for menorrhagia, contraception, HRT (with unopposed oestrogen HRT to prevent endometrial hyperplasia)

Contraindications:

  • current/recurrent PID or STI
  • current pregnancy
  • uterine abnormality distorting the uterine cavity
  • cervical/endometrial cancer
  • breast cancer in last 5 yrs
  • current DVT/ PE
  • IHD
  • liver disease
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13
Q

What is the IUS also called? What does it secrete?

A
IUS = mirena coil
Releases levonorgestrol (progesterone)
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14
Q

IUD (copper) contraception advice following insertion

A

Effective immediately following contraception, no need for extra protection

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15
Q

Risk of copper IUD

A

Makes periods heavier, longer and more painful
Uterine perforation
Expulsion
Small risk of PID in first 20 days
Increased proportion of pregnancies are ectopic

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16
Q

Implant contraception advice following insertion

How long to wait to insert it after TOP

A

Additional protection needed for 7 days if not inserted on days 1-5

Can be inserted immediately following TOP

Best contraceptive option for young people

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17
Q

Side effects and contraindications of implant

A

Side effects: irregular/ heavy bleeding, headache, nausea, breast pain

CYP450 inducers may affect efficacy

Contraindications: IHD/stroke, suspicious vaginal bleeding, previous or current breast cancer, severe liver cirrhosis, liver cancer

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18
Q

Depo provera

  • what does it release
  • how/when is it administered
A

Releases medroxyprogesterone acetate

IM injection every 12 weeks in the upper outer quadrant of the glute

19
Q

Adverse effects and risks of depo provera

A

Irregular bleeding, weight gain, not easily reversible, delayed return to fertility (up to 12m)
Potential increased risk of osteoporosis (so not advised in adolescence)

20
Q

What time window post-partum is safe to have sex without needing contraception?

21
Q

3 types of emergency contraception

A

1.5mg levonorgestrol
30mg ulipristal (EllaOne)
IUD

22
Q

Levonorgestrol emergency contraception

  • dose
  • when to take
  • MoA
  • effect on menstrual cycle
A

1.5mg Levonorgestrol

Must be taken within 72 hours of unprotected sexual intercourse

Thought to stop ovulation and inhibit implantation

If vomiting occurs, repeat dose

Doesnt seem to disturb menstrual cycle

23
Q

Ulipristal (EllaOne)

  • dose
  • when to take
  • MoA
  • Effect on hormonal contraception
  • Effect on breastfeeding
A

30mg

Take within 120 hours

Progesterone receptor modulator -> inhibits ovulation

May reduce effectiveness of hormonal contraception. Restart hormonal contraception 5 days after ulipristal and use extra protection during this time

Delay breastfeeding for one week after ulipristal

24
Q

How long to wait after vasectomy until unprotected sex can happen safely?

What happens in a vasectomy?

How effective?

A

2 month wait because sperm can survive in the ends for a brief period

Prevents sperm entering the ejaculate by bilaterally dividing the vas deferens

Very effective (failure rate <1%)

25
Tubal ligation - what happens - failure rate - associated with what?
Tying.blocking/partial exclusion of fallopian tubes Failure rate 0.75-3.5% Associated with ectopic pregnancies
26
Failure rate of condoms | Advantage of condoms
Failure rate 3-6% | Prevents STIs
27
Risk factors for STIs
``` Under 25 New sexual partner lack of barrier contraception Women undergoing TOP COCP ```
28
Triple swabs for STIs in women
High vaginal (sweep the posterior fornix - candida, trichomonas, BV) Endocervical (1cm into endocervix, rotate gently - gonorrhoea) Endocervix (1cm into endocervix, rotate vigorously for 10s - chlamydia)
29
Chlamydia trachomatis - what is it - symptoms - examination - diagnosis - management - complications
Intracellular bacterium, affects endocervix and urethra Sx: discharge, lower abdo pain, irregular PV bleed, dyspareunia, urinary symptoms Exam: normal, +/- discharge, cervicitis, contact bleeding, adnexal tenderness Diagnosis: endocervical swab, NAAT Mx: 1g oral azithromycin stat, or 100mg oral doxycycline BD 7 days (CI in pregnancy), or 500mg erythromycin QDS 7 days or BD 14 days Complications: PID, ectopics, chronic pelvic pain, infertility
30
Obstetric complications of chlamydia
Prem delivery, foetal growth restriction, low birth weight, increased neonatal morbidity/mortality, still birth, miscarriage, neonatal conjunctivitis, neonatal pneumonia
31
Neisseria gonorrhoeae - what is it - symptoms - examination - diagnosis - management - complications
Gram neg diplococci, affects mucous membranes of endocervix, urethra, rectum, eye and throat Sx: discharge, lower abdo pain, IMB/PCB, dysuria, dyspareunia Exam: discharge, cervicitis, contact bleeding, pelvic tenderness Diagnosis: NAAT, culture from endocervical/ urethral/ rectal/ throat swabs Mx: IM ceftriaxone 1g stat Complications: PID, chronic pain, infertility, ectopics, disseminated gonococcal infection, gonococcal septic arthritis
32
Screening for chlamydia
Offered to all patients aged 15-24
33
Trichomonas vaginalis - what is it - features - diagnosis - treatment - trichomonas in pregnancy
Protozoa infection the vagina, urethra and paraurethral glands Features: vaginal discharge (offensive yellow/green frothy), vulvovaginitis, strawberry cervix, pH >4.5, dysuria, dyspareunia Diagnosis: high vaginal swab culture, direct observation of flagellates on a wet smear microscopy Mx: metronidazole 2g oral stat, or metronidazole 400mg BD 5 days Trichomonas in pregnancy: metronidazole not recommended in early pregnancy, and high dose metronidazole not recommended at all. If necessary, give a 5 day course in tri 1 Complications: PROM, low birth weight, maternal postpartum sepsis
34
Gonorrhoea complications in pregnancy
Perinatal mortality, spontaneous abortion, prem labour, early foetal membrane rupture Neonatal conjunctivitis
35
Genital herpes - what is it - symptoms - diagnosis - management - complications - herpes in pregnancy
HSV type 1 or type 2. virus stays latent after primary infection and then may reactivate, causing infectious viral shedding Symptoms: multiple painful small blisters around labia, dysuria, and vaginal discharge Primary attack most severe: malaise, fever, anorexia, lymphadenopathy Secondary attack: may occur during stress, less severe, may go unnoticed Diagnosis: viral swab from base of lesion (rub to deroof lesion - painful) Management: aciclovir 200mg 5 times a day for 5 days Complications: urinary retention, aseptic meningitis, encephalitis C-section at term if primary attack occurs during pregnancy after 28 weeks
36
Genital warts - what is it - symptoms - examination - diagnosis - management
HPV 6 and 11. Painless unsightly lesions on vagina, cervix, urethral meatus and anus Examination: single or multiple irregular lesions (+/- bleeding, itching) Diagnosis usually clinical (biopsy if pigmented) Management: First line is topical podophyllum or cryotherapy Excision under LA/GA Electrocautery or laser treatment
37
Syphilis - what is it - classification
Treponema pallidum (spirochaete bacterium) Primary: single painless indurated exudative genital ulcer (chancre) with regional lymphadenopathy Secondary: 6-10wks later, malaise, fever, arthralgia, polymorphic rash, condylomata lata (wart plaques in moist areas), generalised lymphadenopathy Tertiary: chronic granulomatous lesions of skin/bones, tabes dorsalis (charcot joint), argyll-robertson pupil, ascending aortic aneurysms, general paralysis
38
Syphilis in pregnancy Features of congenital syphilis
70-100% of babies form infected mothers will have congenital syphilis, with 30% resulting in still births, so treatment should be started ASAP Congenital syphilis: <2yrs. Condylomata lata, saddle nose, deafness, keratitis
39
Hep B in pregnancy
All women offered hep B screening Babies born to infected women get hep B vaccines and hep B immunoglobulin Not transmitted via breast feeding
40
How to reduce transmission of HIV in pregnancy
Reduces vertical transmission fro 30% to 2%: - Maternal antiretroviral therapy during pregnancy - Caesarean section if notable viral load - Neonatal antiretroviral therapy - Bottle feeding (avoid breast feeding) HIV screening in all pregnancy women
41
Bacterial vaginosis - what is it - risk factors - features - diagnosis - management
Overgrowth of anaerobic Gardnerella vaginalis causes eradication of normal lactobacilli and increase in vaginal pH to up to 7 (normally <4.5) Risk factors: smoking, IUD, black women, lots of sex Features: asymptomatic, or offensive fishy smell, profuse thin white/creamy discharge Diagnosis: Amsell's criteria (3 of the 4 must be found): thin creamy discharge, clue cells at microscopy, sniff test (fishy when adding KOH), vaginal fluid pH>4.5 Management: oral metronidazole 400mg BD for 5 days, or 2g metronidazole stat avoid vaginal douching, bath additives and soap
42
Criteria for bacterial vaginosis
``` Amsells criteria 3 out of 4 must be present for diagnosis 1. thin creamy discharge 2. clue cells at microscopy 3. sniff test (fishy odour when adding KOH) 4. vaginal fluid pH >4.5 ```
43
BV in pregnancy
Associated with increased mid-trimester loss, preterm prelabour ROM, preterm delivery and postnatal endometriosis
44
``` Vaginal thrush -what is it -risk factors 0features -diagnosis -management ```
Candida albicans fungus Risk factors: DM, drugs (abx, steroids), pregnancy, immunosuppression (HIV, iatrogenic) Features: asymptomatic, or itching, vulvitis, white lumpy cottage cheese discharge which doesnt smell, dysuria, superficial dyspareunia, vulval excoriation and inflammation, vaginal erythema Diagnosis: microscopy showing spore and pseudohyphae Mx: only indicated in symptomatic cases Cotrimazole pessary, or oral itraconazole/fluconazole Avoid tight fitted clothes, wear cotton, avoid irritants, live yoghurt