Genitourinary Flashcards

1
Q

Discuss priapism and its aetiology

A

Engorgement of the dorsal copora cavernosa resulting in penile erection lasting more than 4 hours

Can occur at any age including the neonate, sickle cell disease is responsible for most cases in children - with nearly 50% of all males with SSD have at least one episode of priapism

Other causes include

  • malignancy
  • immunosuppressive disorders
  • medications
  • drugs of abuse
  • toxins
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2
Q

Contrast low flow and high flow priapism

A

Low flow is the most common form of priapism and occurs secondary to decreased venous out flow.

Stuttering priapism is recurrent episdoes of ischameic priapism most lasting less than 4 hours

High flow priprism is usually painless and is typically associated with trauma to the cavernosal artery, congential anomaly or fistula resulting in excessive inflow of arterial blood and corporal engorgment. - Oxygenation is maintained and emergent intervention is not typically necessary

Neurogenic priapism is not related to blood flow occlusion

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3
Q

Discuss management of priapisms

A

Low flow - is a compartment syndrome of the penis and requires emergent treatment. Management include
-hydration
-pain relief
-relief of urinary obstruction
-and treatment of underlying cause
Ring block of the penis should be performed prior to aspiration followed by intracavernous injection of sympathomimetic drugs. Pheylephrine is the preferred agent

Treatment of nonischaemic priapism is observation becuase over 2/3 of cases resolve spontaneously - refractory cases may require cavernosal artery embolization or arterial ligation

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4
Q

Discuss aspiration of the corpus cavernousum in priapism

A

Ring block
Place an 18 gauge angiocatheter - (smaller for younger children) percutaneously into the lateral aspect of the penile shaft entering the corpus cavernosum. Aspirate blood and evacuate from the cavernosa. Next irrigate with normal saline or in combination with dilute phenylephrine (100-500 mic of pheylephrine per mil of NS

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5
Q

Discuss complications of priapism

A

Penile firbosis
urinary retention
impotence

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6
Q

Discuss differentiating high flow and low flow priapism

A

Penile blood appearance

  • low flow – venous looking
  • high flow – arterial looking

Penile art gas

  • Low flow, Pao2 <30mmhg, paco2 >60mmhg, ph <7.25
  • high flowm pao2 >90mmhg , paco2 <40mmhg ph 7.4

Doppler
low flow - minimal or absent blood flow
high flow - blood flow normal to high velocity

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7
Q

Discuss phimosis

A

Constriction of the foreskin that prevents retraction of the prepuce from the glans. Most cases are physiological repreent normal development and do not require intervention.

Those with fully retractable foreskins 
4% of newborns 
25% of 6 month old 
50% of 1 year old 
80% of 2 year old 
90% of 4 year old boys 

Trauma, infection, chemical irritation, poor hygiene congenital abnormality or a complciation of cicumcision may contribute to the development of phimosis

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8
Q

Discuss management of phimosis

A

Gentle retraction and good hygiene are mainstays of management. Retraction of the prepuce should not be forced as this could lead to future adhesions and strictures.

A 6-8 weeks course of topical corticosteroids applied to the outlet twice daily may expedite the developemnt of retractable foreskin.

Disposition
-patient who are able to urinate and have no evidence of infection or ischaemia can be discharged with OPD urology follow-up

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9
Q

Discuss paraphimosis

A

Pathalogical condition in which the proximal foreskin is unable to be returned to its anatomic position covering the glans penis resulting in distal venous congestion

Can be caused infection, masturbation, trauma, hair or clothing tourniqutes or failure to reduce the foreskin

It is a urological emergency with potential for arterial compression, penile necrosis, gangrene and/or autoamputation

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10
Q

Discuss management of paraphimosis

A

Pain should be controlled parenterally and/or with a local dorsal penile nerve block or ring block
Oedema should be reduced –> sprinkle granulated sugar, apply pressure
May spont resolve as oedema resolves, If not manual reduction should be attempted with application of gentle steady pressure on the glans with both thumbs while the shaft is pulled straight

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11
Q

Discuss balanoposthitis

A

An inflammation that ivovles the glans foreskin, occurs in approximatly 5% of uncircumcised males.

Balanitis invovles the glans penis only.
usually secondary to poor hygeine, infection (bacterail or fungal) contact dermatitis, chemical irritation, or local trauma.

Less common causes include

  • drug eruption
  • scabies
  • STI
  • Nummular eczema
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12
Q

Discuss management of balnoposthitis

A

Emphasis on adequate hygiene with sitz baths to reduce inflammation. Painful micturation can be addressed by having a child urinate while in warm water baths.
Antibiotic ointments should be used for bacterial superinfection and topical corticosteroids may speed recovery.
If candida suspected antifungla should be used

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13
Q

Discuss complications and benifits of cicumcision

A

Prevents phimosis, paraphimosis, recurrent balanoposthitis and decreases UTIs STI and penile cancer.

most common complciation is minor bleeding

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14
Q

Discuss Entrapment and constrictive injury

A

Penile rigns, strings, wire and human hair tourniquets can result in penile venous and arterial occlusion. These should be removed and patient ensured that they can pass urine prior to discharge

Zipper entrapment of the foreskin typuically occurs in chidlren between 2 and 6 years of age. LA or sedation may facilitate removal. Cut the median bar of the zipper with mini-hacksaw or metal cutter

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15
Q

Discuss epididymitis

A

Is inflammation of the epididymis. Infectious causes vary by age. Young children commonly have viral infections. Bacterial epidiymitis in prepubertal boys is associated with structural anomalies of the urinary tract

Gonorrhoea and chlamydia are common causes in adolescents

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16
Q

Discuss clinical features of epididymitis

A

Presnets with a painful oedemaotus scrotum and tenderness at the epididymis. Urethral discharge may be present particularly when the condition is secondary to STI

Relief of pain with scrotal elevation (Prehns sign) is unreliable and should not be used to make a diagnosis

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17
Q

Discuss IX of epididymitis

A

Urine sample –>
Swab if puss
US to differentiate from torsion

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18
Q

Discuss management of epididymitis

A

Scrotal elevation and pain medications. If concerned for STI should be treated presumptively
Ceftriaxone IM and doxyxycline is the preferred treatment. Or azithromycin

In children with non STI epididymitis expectant management wihtout ABs can be undertaken

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19
Q

Discuss orchtiis

A

Result of bacterial or viral infection of the testes

Paramyxovirus is the most common associated with mumps. Other etiology include e.coli, klebsiella, pseudomonas, staph or strep. EBV, coxsackie, abrovirus, enterovirus, brucella, granulomatous, and filariae

Viral orchitis is mangemed with pain controle, if bacterial possible treat with orals covering gram -ve

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20
Q

Discuss testicular torsion

A

Most common cause of an acutely painful scrotum
Nearly 100% of testes can be salavaged if de-torted within 4 hours less than 10% if more than 24 hours
Bell clapper deformity(Tunica vaginalais completely covers the testis and attaches higher up on the spermatic cord) increases the risk of torsion

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21
Q

Discuss clinical features of torsion

A

ACute pain and swelling
elevated testicle
absence of the cremasteric reflex
abnormal (high riding and transverse) epididymal and testicular position may also be noted

Ultrasound is 85-98% sensitivty depending on operator and 100% specific

Both the appendix of the testis and the epididymis can torse but the former is more common
The pathognomic blue dot sign is present in less than 25% of cases

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22
Q

Discuss management of torsion

A

Should be operative
historically manual detorting has been attempted with analgesia and medial to lateral rotation
up to a 1/3 of patient have torted laterally and the above can worsen the torsion
even with successful detorision compartment syndrome may occyur

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23
Q

Describe idioptathic scrotal oedema

A

erythema and induration of the scrotum that is typically painless but may be pruritic
Most cases are unilateral and usually occur in prepubertal boys aged 5-11 year sof age.

Nil tenderness to palpation of the teste
Ultrasound will show thickened scrotal wall and icnreased peritesticular blood flow

Can be discharged home with NSAIDS and scortal support

24
Q

Discuss inguinal herniesa

A

Both direct and indirect are more common in males with bimodal peaks before 1 year of age and after 40 years

Infants are anatomically at risk for an inguinal hernia secondayr to a short inguinal canal that croses teh abdominal wall perpendicularly
Premature infants are at double the risk
Incarceration are more common in gilrs. and infants often present incarcerated

25
Q

Discuss UTIs in children

A

Most common cause of fever in young children
neonatal boys are more susceptible than girls but beyond that females have a much high risk
Vesicuoureteral reflux from the bladder into the ureter is a common cause of recurrent urinary infecitons.

E.coli is the most common pathogen
Enterobacter, proteus, morganella, serratia and salmonella,

UTI in infants yonger than 3 months ar eassociated with baceremia in up to 50% of cases

26
Q

Discuss the nitrite test

A

Measures conversion of nitrates to nitrites by gram -ve bacteria, may not be +ve in young children who urinate frequently

27
Q

Discuss management of UTI in infants younger than 2 months, 2months to 2 years, and older than 2 years

A

Much high risk of sepsis. Formely reccomended that all infants under 2 months with UTI should have full septic screen and admission for IVABS. Some recent studies have suggested that is may be safe in a subset of patient to be treated in OPD setting

2 months -2 years
Can be treated as an OPD
UTI in this age group are considered to be upper tract disease process 7-14 day courses should be used

Older than 2 years
simple cystitis should have a 3 day course of ABs

28
Q

List DDX of dysuria in children

A
INfection 
-UTI 
-Vaginitis (gardnerella, trichomonas, or STI) 
Pinworms 
-balanitis 

Irritation

  • Bubble bath, new soups
  • foreing body

Trauma

  • Sexual or physical abuse
  • Strddle injury
  • self stimulation or masturation

Other

  • labial adhesions ‘
  • stones
29
Q

Discuss DDX of haematuria in children

A

Extra-renal

  • Trauma
  • Meatal stenosis or posteiror urethral valves
  • exercise
  • menstraution or rectal bleeding
  • foreign bodies
  • cystitis, urethritis, epididymitis

Renal

  • Pyelo
  • Renal or bladder stones or tumorus
  • Post strep or idiopathic GMN
  • AIN
  • ATN
  • Basement membrane glomerula disease
  • renal vein or artery thrombosis
  • recurrent familial haeaturia
  • PCKD

Systemic

  • Alport syndrome neprhitis (recessive X-linked disorder that is typically seen in males and is often accompanied by high-frequency sensorineural hearing loss (SNHL), ocular abnormalities including anterior lenticonus, and, over time, progressive renal failure)
  • HSP
  • SLE
  • Haemolytic ureamic syndrome
  • EBV (MONO)
  • sickle cell disease or other haemoglobinopathies
  • Bacterial endocarditis
  • bleeding disorders
  • drugs
30
Q

Discuss ix of haematuria

A

5 RBC or more incidcates haematuria

THe presence of WBC, nitrates or leukocyte esterase indicates infection

RBC casts, large p[roteinuria, HTN or renal insufficency may indicate glomberula pathology

ESR and ANA for SLE

If well and no cause found the child should follow-up with primary care provider for a 24 hours urine collection

31
Q

Discuss the evaulation of proteinuria in children

A

Trace to mild proteinuria (1+ to 2+) is a common laboratory finding in young children and can represent many benign conditions such as exercise or dehydration.

If the amount is significnat such as in nephrotic syndrome the resultant hypoalbumineamia may cause
generalised oedema

Disposition

  • Children with significant oedema and ascitis, significant HTN or makred renal impariment should be hoispitalized
  • otherwise can be managed as OPD with close follow-up
32
Q

Discuss DDX of proteinuria

A

Can be glomerula or tubular

Glomerular

  • nephrotic syndrome
  • glumeruloneprhitits
  • posttransplantation rejection

Tubular

  • heavy metal poisoning
  • UTI
  • diabetes
33
Q

Disucss IX of proteinuria

A
Mild proteinuria (<=2+ or <100mg/dl) requires no further IX. 
Evidence of UTI such as WBC or positive luekocyte exterase or nitrate level should be treated 

Moderate proteinuria (3+ or >300mg/dl) should have additional investigation

  • Serum protein and albumin
  • electrolytes
  • BUN
  • creatinine levels
  • urine culture

Random PCR (protein creatine ratio) corrleates well with 24 hours urine collection

  • normal is less than 0.2mg/gl
  • urine PCR more than 3mg/dl corrleates with nephrotic syndrome

ASO can be used to identify previous strep infections

34
Q

Discuss Post strep glomerulonephritis

A

PSGN is the most common glumerulonephritide
Sequalae of streptococcal pharyngitis and less commonly skin infection
PSGN is believed to reuslt from the deposition of circulating immune complexes on the kidney.

Typically occurs in children 3-7 years of age usually with a history of pharyngitis with fever 2 weeks before the onset of nephritis.
Symptoms can be loclaised to the urinary tract manifest as
-haematuria
-f;lank pain
-lethargy
-generalised oedema

Renal failure is found in 2% of cases

35
Q

Discuss investigation of PSGN

A

Urinarlysis shows significant haematuria andprotein with RBC cast in 60% of cases
Other finding include pyuria with granular or hylar cast

BUN elevated
hyponatraemia and hyperkalaemia
ASO tirtre and IGG elevation
C3 and C4 decreased

36
Q

Discuss DDX of PSGN

A
IGA nephropathy (GIT and respiratory infection)
Goodpastures
Wegeners granulomatosis 
Alport
HSP 
HUS
37
Q

Discuss management of PSGN

A

Fluid and Na restriction
Diuretics in consult with paeds (thiazides 1st line followed by loop for more signifiacnt disease)
AB not indicated
Antihypertensives if needed (CA or B blocakde)

THose with CCF, uremia or significant HTN should be admitted otherwise can be managed as OPD after talkking to the friendly paeds chaps.

38
Q

Discuss nephrotic syndrome in children

A

Characterised b significant proteinuria, hypoproteinemia and oedema. +loss of clotting proteins and immunoglobulins

Primarly commonly occur in children younger than 5 the majority of which are minimal change
Secondary neprhotic syndrome is usually seen in older children from systemic illness such as PSGN or SLE

39
Q

Discuss clinical features

A

Onset of oedema may be insidious beginning with periorbital oedema.
Children are not usually ill unless there is pulmonary oedema or ascites
HTN, haematuriaor oliguira can also be present

Nephrotic children are at increased risk of thrmobosis with 2% developing thromboembolic complications

40
Q

Discuss IX of nephrotic syndrome

A

Nephrotic range proteinuria is more than 3.5g of proetin or more than 50mg/kg

Complement is reduced in nephrotic syndrome
hyperlipidaemai occurs in neprhotic syndrome for not completley understood reason

41
Q

Discuss management of nephrotic syndrome

A

Despirte oedema children with signs of hypovolaemai should be treated with cyrstalloids
Patients with presumptive diagnosis of primary neprhotic syndrome can be treaeted with steroids

If signs of ascites or pulmonary or pleural odema should have loop diuretics and may need fluid and salth restriction

As children with neprhotic syndrome are relatively immunodepressed due to loss of IG any fever should be treated in hosiptal with IVIABs

42
Q

Discuss DDX of AKI in children

A

Pre-renal

  • Decreased intravascular volume or dehydaration
  • -burns
  • -third spacing
    • sepsis
  • Decreased CO
  • -Caridiogenic shock
  • Decreased renal artery blood flow

Intrarenal

  • Glomerula disease
  • -PSGN and orthers
  • -Pyelo
  • Systemic casues
  • -HUS
  • -HSP
  • -SLE
  • -Sepsis
  • Toxins
  • -heavy metals
  • -myoglobin or haemoglobin deposits
  • -ABs such as aminoglycosides
  • -anticonvulsants
    • radiocontrast dyes

Post renal

  • obstructive lesions
  • nephrolithiasis or tumor
  • post urehtral valves
  • intrabadominal tumor obstructing urinary flow
  • infection
  • renal vein thrombosis
43
Q

Discuss HTN in children

A

Defined as a systolic or diastolic blood pressure higher than 2 standard deviations above the mena for the age

Blood pressure upper limit for age 
0-2: 110/65
3-6: 120/70
7-10: 130/75
10-15: 140/80
44
Q

Discuss DDX of HTN in children

A

Renal

  • Nephritic or nephrotic syndromes
  • HSP
  • Pyelo
  • Obsturctive or reflux
  • PCKD
  • diabetic nephrtopathy
  • trauma
  • renal transplant
  • tuberous sclerosis
  • SLE

Endocrine

  • Phae
  • Cushings
  • congenitial adrenal hyperpalsia
  • corticosteroids treatment
  • hyperthyroduism
  • neuroblastoma
  • ovarian tumor

Cardiac

  • CCF
  • coarctation of the aorta

Vascular

  • HUS
  • Kawasaki syndrome
  • Rneal artery thrmobosis or stenosis

Neurolgoic

  • CNS tumor or infection
  • CNS trauma or abuse
  • Rasied ICP
  • Guillian Barre syndrome

Neoplastic

  • neuroblastoma
  • Wilms tumor
  • Phae
  • Adrenal carcinoma

Drgus

  • Corticosteroids
  • cocaine
  • sympathomimetics
  • OCP
  • Phecyclidine
  • B blockade or clonidine withdrawlal
45
Q

Discuss HSP

A

Is an immunoglobulin A mediated systemic vasculitis involving the small blood vessels of the skin, GIT and joitns

The peak incidence for HSP is between 4-7 years of age

50% of affected children have a history of previous upper respiraotry tract infection and as many as 75% have group A beta haemolytic strep

46
Q

Disucss clinical features of HSP`

A

Hallmark is a palpable purpuric or petehcial rash. This is seen in the vast majority of patients and is most prominent on the lower extremities starting at the lateral malleoli

Arthralagia and arthritis are common usually involved knees and ankle joints
Dull peri-umbilical pain resulting from bleeding into the intestinal wall occurs in at least 50% of cases

Self limiting glomerulonephritis will develop in 25-50% of cases manifested by haematuria with or without RBC cast

47
Q

Discuss IX of HSP

A

Urine and urinanylysis for RBC and CAST + protein
BUN and creat levels
FBC
Coags
US of the abdomen wif significant abdom signs

48
Q

Discuss management of HSP`

A

Most cases resolve spontanesouly and do not require threapy
NSAIDS for pain
corticosteroids reduce time course

49
Q

Discuss HUS

A

A microangiopathic haemolytic anaemia is one of the most common causes of AKi in children

HUS is rare after the age of 5 years of age but recurrence is more common in older children and mortality is 30%

Most common cause is Shiga toxin producing e.coli
Transmission is through person to person contact or exposure to contaminated food

HUS can be classified as primary cause by compliment dysregulation and secondary caused by infection

Renal compromise is caused by vascular endothelium injury induced by viral or bacterial agents. RBCs are injured within the narrowed blood vessels resulting in a microangiopathic haemolytic anaemia. Platelets complement and fibrin are deposited in the glomerular lumen resulting in thrombocytopenia, decrease in the GFR and renal failure

50
Q

Discuss clinical features of HUS

A

Secondary HUS from STEC present with watery diarrhoea crampy abdominal pain and occasionaly fever. Within days of symptoms increasing abdominal pain with 50-85% of patient developing bloody stool.

up to 10% of patients will experience the triad of sudden onset of haemolytic anaemia, thrombocytopenic and acute renal insufficiency with possible progression to renal failure.

Up to 60% of diarrhoea related HUS cases require dialysis and death or ESRD occur in 12%

51
Q

Discuss compolciations of HUS

A

Renal

  • AKI
  • CKD

GIT

  • toxic megacolon,
  • ischaemic colitis
  • intussusception
  • perforation
  • delayed colonic stricutre ‘

Systemic

  • Anaemia
  • Thrombocytopenia
  • HTN
52
Q

Discuss management of HUS

A

Early peritoneal dialysis and supportive measure current mortality is less than 5%
Fluid resus if dry
electrolyte management (hyper K common)

Do not given antimotility agents
Antibiotics have not be shown to prevent HUS from STEC and may increase the release of verotoxins and worsen sytmpoms

53
Q

List conditions possibly causing persistant conspitation

A

1) mec ileus
2) anal anomalise (stenosis, stricter, malposition)
3) spinal anomalise
4) hirschprung’s
5) hypothyroidism
6) metabolic - hypercalcium, hypokalaemia
7) coeliac disease
8) cows milk intolerance
9) lead poisoning
10) intellectual impairment
11) child abiuse
12) CF
13) dietary
14) psychogenic
15) drug releated

54
Q

Discuss managment of constipation

A

1) exclude physical treatable cuases with carful history exam and ix
2) empty rectum preferably from the top
3) esatblish a pharmacological bowel rhythm and pattern which may need support for years
4) allow the nelarged rectum to re-restablish it own inherent physiologcial bowel pattern and tone and to regain its normal sensation
5) continue maintenance for some time before considering slowly weaning off pharmaceuticalls

This will involve

  • enthusiasm on part of managing clinicians
  • non punitve behaviour on part of the parents
  • adjunctive behavioural modification interventiojns with achievable golas including motivational praise with star and reward charts
55
Q

Discuss approach to disimpaction

A

If consitpation is severe the bowel may need disimpaction before maintenance treatment can be commenced

1) oral OPD faecal disimpaction is the preferred method. Macrogel 3350 sachets are tolerated better if cooled in the fridge. They are administered by esclated dose.
- age 2-5 one sachet on day 1, 2 on day 2and 3, 3 on day 4 and 5 and 4 on day 6 and 7

Rectal disimpaction is avoided when possible

Inpatient disimpaction
-this is usually a planned admission involving the administration of bowel preparation fluid via a NGT.