Genoderms True False Dan

Question 1

50% of new cases of Gorlin’s syndrome are due to new mutations

Answer 1

True

Question 2

Osteomas of the maxilla or mandible are a late feature of Gardner’s syndrome

Answer 2

False

Occur early

Question 3

In gardner’s syndrome w/out surgery, development of colorectal ca is inevitable

Answer 3

True

Question 4

Odontogenic jaw keratocysts in Gorlin’s may be aggressive causing bone resorption and pathological fractures

Answer 4

True

treat them early

Question 5

90% of MEN2B pts get medullary thyroid cancer in the first or second decae of life

Answer 5

True

Question 6

MEN2B is due to a recessive mutation in the RET (protoonco)gene

Answer 6

False

autosomal dominant

Question 7

Dystrophic EB has the most severe oral involvement of any EB esp the recessive form

Answer 7

True
Recessive form; caries/diffuse oral ulcerartion/scarring/microstomia/vestibular obliterationDominant form similar but not as severe

Question 8

Circumoral and oral pigmented macules of Peutz-Jeghers fade from puberty

Answer 8

False

circumoral do but oral/vermillion ones do not