GEP (Life structure) Week 3 Flashcards
How do NSAIDS Work
What are COX enzymes and the different types
Selectivity and side effect of NSAIDS
Summary of the mechanism and side effects of NSAIDS
- NSAIDS work by blocking COX enzymes, non selective block COX 1 and 2 (Aspirin, ibuprofen, naproxen - antipyretic, analgesic and anti-inflammatory they are anticoagulants and can also be partially allergic and can induce bronchospasm as some have a role in bronchodilation. Aspirin is unique in that it mostly works to block thromboxane A2 which normally causes platelet aggregation thus aspirin thins the blood. ) or specific which block COX 2 not 1 (COXIBS)
- COX 1 maintains homeostasis particularly in stomach and kidneys and so inhibiting has a bad effect on organs e.g. COX 1 converts arachidonic acid to PGH2 which forms PGE2 and PGI2 which help decrease acid production in the stomach by inhibiting COX 1 you allow more acid to produced in the stomach so side effects, dyspepsia, vomiting nausea and haemorrhage long term high dose consequences.
- In kidney cox 1 converts arachidonic acid into PGH2 which makes E2 and I2 which help maintain renal blood flow therefore NSAIDS can cause nephritis and kidney injury.
- Selective NSAIDS created to reduce side effects of nonselective e.g. paracetamol.
- In kidney cox 1 converts arachidonic acid into PGH2 which makes E2 and I2 which help maintain renal blood flow therefore NSAIDS can cause nephritis and kidney injury.
Revison of NSAIDS from previous modules
Steps of inflammation and healing
Types of Collagen
Type 1: bONE
Type 2: car2lage
Type 3: arte3s
Type 4: basement 4loor
Different types of white blood cells involved in Inflammation
What are the outcomes of Acute inflammation
Brief anatomy of the elbow
The elbow is the joint connecting the upper arm to the forearm. It is classed as a hinge-type synovial joint.
The elbow joint consists of two separate articulations:
-Trochlear notch of the ulna and the trochlea of the humerus
-Head of the radius and the capitulum of the humerus
Note: The proximal radioulnar joint is found within same joint capsule of the elbow, but most resources consider it as a separate articulation.
CRAzy TULips
Capitulum = RAdius (capitulum of the humerus articulates with the head of radius)
Trochlea = ULnar (the trochlea of the humerus articulates with the trochlear notch of the ulna)
The humerus begins proximally as a rounded head and joins the greater and lesser tubercles via the anatomical neck of the humerus. The surgical neck is found just inferior to the tubercles where the shaft begins.
The articulations of the elbow
The elbow is the joint connecting the upper arm to the forearm. It is classed as a hinge-type synovial joint.
The elbow joint consists of two separate articulations:
Trochlear notch of the ulna and the trochlea of the humerus
Head of the radius and the capitulum of the humerus
Ligaments of the elbow
Different types of elbow movements
As the elbow joint is a hinge joint, movement is in only one plane. The movements at the elbow joint involve movement of the forearm at the elbow joint. Flexion of the forearm at the elbow joint involves decreasing the angle between the forearm and the arm at the elbow joint. Extension involves increasing the angle between the arm and forearm. These movements are performed by two groups of muscles in the arm: the anterior compartment and the posterior compartment of the arm.
While flexion and extension are the only movements that can occur at the elbow joint itself, movement is also afforded at the proximal radioulnar joint, which contributes to the elbow joint. Movements at this joint are called pronation and supination. These are rotational movements that occur when the distal end of the radius moves over the distal end of the ulna by rotating the radius in the pivot joint formed by the circular head of the radius, the radial groove of the ulna and the annular ligament.
Pronation and supination of elbow
Pronation and supination are movements that occur at the radioulnar joints. The head of the radius is discoid and fits with the radial neck within the circular annular ligament, that attaches the proximal radius to the ulna. The wheel like rotation of the head of the radius enables supination (palm facing upwards), and pronation (palm facing downwards).
Several tendons connect the muscles and bones of the elbow. The primary tendons are:
biceps tendon, which attaches the biceps on the front of the arm to the radius, enabling you to forcefully bend your bend your elbow
triceps tendon, which attaches the triceps to the ulna, enabling you to forcefully straighten your elbow .
Muscle compartments of the upper arm
Muscle compartments of the upper arm
Anterior Compartment (Flexion) – brachialis, biceps brachii, coracobrachialis
Posterior Compartment (Extension) – triceps brachii and anconeus
Note – pronation and supination do not occur at the elbow – they are produced at the nearby radioulnar joints.
Anterior compartment of the arm
There are 3 muscles located in the anterior compartment of the upper arm:
Biceps Brachii
Coracobrachialis
Brachialis
They are innervated by the musculocutaneous nerve.
A memory aid for this is BBC - Biceps, brachialis and coracobrachialis.
Arterial Supply to the anterior compartment of the upper arm is via muscular branches of the brachial artery.
Posterior compartment of the arm
There are 2 main muscles involved in the posterior compartment of the arm involved in arm extension, they are:
Triceps Brachii
Anconeus
They are innervated by the radial nerve.
The arterial supply to the posterior compartment is via the profunda brachii artery,
Muscles that act on the elbow to move forearm
Main artery supply to the upper limb
The main artery supplying blood to the upper limb is the subclavian artery. The trunk of the subclavian artery is continuous throughout the entire upper limb.
During its pathway, the artery changes its name based on the region it supplies. Thus the major named arteries of the upper limb are: the subclavian artery, the axillary artery, the brachial artery, and the ulnar and radial arteries.
What is the cubital fossa
The cubital fossa is triangular in shape and consists of three borders, a roof, and a floor:
Lateral border – medial border of the brachioradialis muscle.
Medial border – lateral border of the pronator teres muscle.
Superior border – horizontal line drawn between the epicondyles of the humerus.
Roof – bicipital aponeurosis, fascia, subcutaneous fat and skin.
Floor – brachialis (proximally) and supinator (distally).
Mnemonic for contents of the cubital fossa – Really Need (radial nerve) Beer To (biceps tendon) Be At (brachial artery) My Nicest (median nerve).
What is the acute management for shoulder dislocation
Acute Management
Ideally, the shoulder should be relocated as soon as safely possible. Muscle spasm occurs over time, making it harder to relocate the shoulder and increasing the risk of neurovascular injury during relocation. Acute management of a shoulder dislocation involves:
- Analgesia, muscle relaxants and sedation as appropriate
- Gas and air (e.g., Entonox) may be used, which contains a mixture of 50% nitrous oxide and 50% oxygen
- A broad arm sling can be applied to support the arm
- Closed reduction of the shoulder (after excluding fractures)
- Dislocations associated with a fracture may require surgery
- Post-reduction x-rays
- Immobilisation for a period after relocation of the shoulder
There are various options for closed reduction of shoulder dislocations. See local guidelines and get experienced senior input when managing shoulder dislocations and for guidance on relocation techniques.
What is the ongoing management for shoulder dislocation
There is a high risk of recurrent dislocations, particularly in younger patients. Physiotherapy is recommended to improve the function of the shoulder and reduce the risk of further dislocations.
Shoulder stabilisation surgery may be required to improve stability and prevent further dislocations. This may be an arthroscopic or an open procedure. Underlying structural problems are corrected, such as:
- Repairing Bankart lesions
- Tightening the shoulder capsule
- Bone graft using bone from the coracoid process to correct a bony injury to the glenoid rim (Latarjet procedure)
- Correcting Hill-Sachs lesions (Remplissage procedure)
There is a prolonged period of recovery and rehabilitation after shoulder stabilisation surgery (3 months or more). Recurrent instability and dislocations can occur in up to 20% of patients after surgery.
Anatomy of the shoulder
The sternal end is a large facet that articulates with the manubrium to form the sternoclavicular joint (Saddle-shaped synovial joint)
The shaft of the clavicle has attachment sites for the deltoid, trapezius, subclavius, pectoralis major, sternocleidomastoid and sternohyoid.
The acromial end attaches to the scapula via the acromioclavicular joint (Plane type synovial joint)
The scapula connects to 17 different muscles!
The costal surface is on the side of the ribs and from the subscapular fossa originates the subscapularis muscle from the coracoid process (The big hooky bit) Originates the pectoralis minor, coracobrachialis and the short head of the biceps brachii (Brachii = 2). The posterior surface is the site of origin for the majority of the rotator cuff muscles (SITS muscles = Supraspinatus, Infraspinatus, Teres minor and Subscapularis)
The humerus has a greater and lesser tuberosity. The greater tuberosity provides an attachment site for three of the rotator cuff muscles (SIT - Supraspinatus, infraspinatus, and teres minor)
The lesser tuberosity is an attachment site for the last rotator muscle - The subscapularis
Important injury site = Surgical neck fracture -> risk of damage to axillary nerve and posterior circumflex artery
Important fact!! Surgical neck fracture damaging the axillary nerve lead to difficulty abducting the affected limb (Paralysed deltoid and teres minor) and numbness over the regimental badge area
Muslces involved in the movement of the shoulder