Geriatrics Flashcards
(95 cards)
What is frailty?
Age related syndrome of physiological decline characterized by marked vulnerability to adverse health outcomes
5 indicates of frailty
- weight loss 4-5kg
- Exhaustion and fatigue
- Low activity
- Weakness or low grip strength
- Slowness or slowed gait speed
Fragility index score
70 clinical deficit questions. Presence of 25 or more —> .025 (10 present/40 considered).
What is the comprehensive geriatric assessment tool
Multidimensional and multidisplinary diagnostic and therapeutic process conducted to determine the medical, mental, and functional problems of older adults with frailty
1. Develop a coordinated plan to maximize overall health with aging
Major components of geriatric assessments
- Functional capacity
- Fall risk
- Cognition
- Mood
- Poly pharmacy
- Social support
- Financial concerns
- Goals of care
- Financial planning.
Wat gender and ethnicity to live linger
Women änd white
Definition of aging
progressive decline and deterioration of functional properties at the cellular, tissue, and organ level that lead to a loss of homeostasis, decreased ability to adapt to internal or external stimuli, and increased vulnerability to disease and mortality.
Metric for aging for clinical decision making?
Physiological age, and not chronological age
Genetic Variations linked with Alzheimer’s disease
APOE, the most common Alzheimer disease risk gene.
(Apolipoprotein)
& protocadherin 11 X-linked (PCDH11X)
Cardiovascular changes with aging.
Increased:
left ventricular wall thickness
lipofuscin and fat deposits
ventricular stiffness
Decreased:
maximum heart rate
heart rate variability
responsiveness to receptor-mediated agents
Decreased:
cardiac output and vascular compensation in orthostasis, sepsis, etc
Digestive changes with aging
Increased:
dysphagia
achlorhydria
lipofuscin and fat deposition in pancreas
mucosal cell atrophy
Altered intestinal absorption
Decreased:
iron, B12 and calcium absorption
Age changes with ears
Increased:
conductive deafness (low-frequency sounds)
sensorineural hearing loss (high-frequency sounds)
Decreased:
detection of gravity, changes in speed, and rotation
Age changes with eyes
Decreased:
transparency of the cornea
accommodation and dark adaptation
Difficulty in focusing on near objects
Endocrine changes with age
atrophy of certain glands (eg, pituitary, thyroid, thymus)
parathyroid hormone, atrial natriuretic peptide, norepinephrine, baseline cortisol, erythropoietin
Decreased:
growth hormone, dehydroepiandrosterone, testosterone, estrogen
Changes in target organ response, organ system homeostasis, response to stress, functional capacity
Age changes with immune system
Increased:
autoimmune syndromes
monoclonal gammopathies
reactivation of latent infections
systemic chronic inflammation
Decreased:
vaccine responses
fever response to infection
response to new pathogens
T lymphocytes, natural killer cells, cytokines needed for growth and maturation of B cells
Age changes with muscle
Decreased:
muscle mass
tone and contractility
strength
Biomarker: grip strength
age changes with nervous system
Decreased:
muscle innervation
fine motor contro
Age changes with skin
Decrease elasticity - delayed skin tugor
Age changes in renal system
Decreased:
concentrating ability of kidney
renal clearance of drugs, toxins
ability to resorb glucose
The brain commonly shows volume loss, microvascular changes in white matter, reduced cerebral blood flow, increased permeability of the blood-brain barrier, reduced glucose uptake and utilization, and accumulation of amyloid plaques.
What is most common causes of mobility, functional decline in older adults
Sarcopenia, the geriatric syndrome of reduced skeletal muscle mass and strength, is one of the most important causes of mobility decline, functional decline, and loss of independence in older adults.
Bone mass (or density) is lost with aging, especially in women after menopause, and bones become more brittle.
What is presbycusis
Significant age-associated hearing loss is termed presbycusis
Selection, Optimization, and Compensation model (SOC)?
As individuals age, and realize that their resources, including both cognitive and physical energy, may be limited, they adapt by selecting what is important, optimizing function, and compensating as needed so that desired activities can still be enjoyed.
Example:: enjoy gardening, but have difficulty kneeling or standing outside for long periods of time, can compensate by taking more breaks or working in shorter blocks of time, by reducing the size of the garden, or by moving some gardening indoor