Gestational Trophoblastic Neoplasia Flashcards
Beckwith-Weidemann Triad
- Macrosomia
- Hemihypertrophy
- Macroglosia
Placental Findings:
NORMAL terminal villi with HYDROPIC stem villi. NO trophoblastic hypertrophy
Placental Mesenchymal Dysplasia
FIGO GTN staging:
Confined to Uterus
Stage I
FIGO GTN staging:
Metastasis to LUNGS even WITHOUT evident spread to the adnexa or broad ligament.
Stage III
FIGO GTN staging:
Extends beyond the uterus WITH involvement of the adjacent reproductive organs (adnexae, broad ligaments…etc.)
Stage II
FIGO GTN staging:
Uterine involvement with distant mets to other organs
Stage IV
Most common form of GTN
Complete H- Mole
Molar pregnancy is characterized by DIPLOID karyotype, which is paternal in origin. 46 XX or 46 XY
Complete H mole
GTN that is almost always Triploid. Normal ovum fertilized by 2 sperms. 69 XXX or 69 XXY. With Fetal parts.
Partial H mole
Bilateral cytic ovarian lesion seen in 2nd trimester, resulting from high HCG in molar pregnancy with US features of: SOAP BUBBLE or SPOKE-WHEEL appearance
Theca Lutein Cyst
FIGO Criteria for Dx of Persistent GTN:
1. Plateauing of HCG in 4 measurements over a 3 week period or more
True
FIGO Criteria for Dx of Persistent GTN:
2. Rising HCG in 3 consecutive weekly measurements over a period of 2 weeks or more
True
FIGO Criteria for Dx of Persistent GTN:
Histology of choriocarcinoma
True
FIGO Criteria for Dx of Persistent GTN:
Persitently elevated HCG for 6 months or more post evacuation
True
Syndrome associated with Placental Mesenchymal Dysplasia characterized by congenital overgrowth disorder
Beckwith-Weidemann Syndrome
