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RENAL PHYSIOLOGY > GFR > Flashcards

GFR Flashcards

(51 cards)

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1
Q

GFR

A
  • is the rate at which fluid is filtered in the bowman capsule
  • in a health male 120ml/min
  • 180L/day
  • 1 kidney removed GFR decreases 25%
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2
Q

increasing glomerular capillary pressure

A
  • will increase the decreasing GFR
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3
Q

main factor in determining GFR

A
  • glomerular capillary pressure
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4
Q

GLOMERULAR CAPILLARY PRESSURE is proportional to

A
  • GFR
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5
Q

plasma protein oncotic force (oncotic pressure of glomerular capillary)

A
  • promotes reabsorption
  • the more concentrated the proteins the greater the force promoting reabsorption
  • decrease GFR
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6
Q

diarrhea
vomiting stomach contents
excess sweating
is losing fluid in the body but not protein

A
  • plasma protein concentration increases

- decrease GFR

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7
Q

plasma protein become more concentrated

A
  • decrease GFR
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8
Q

decreasing plasma concentration of protein

A
  • increase GFR
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9
Q

drinking water no protein content
saline infusion
saline induced diuresis (proximal tubule)

A
  • diluting the plasma protein

- increase GFR

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10
Q

oncotic pressure of bowman’s space

A
  • ZERO
  • opposing filtration
  • does not affect GFR
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11
Q

blocking ureter or urethra with kidney stone
high bladder pressure
post renal failure

A
  • fluid cannot move freely causing pressure in the bowman space
  • DECREASE GFR
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12
Q

increase hydrostatic pressure

A
  • increase filtering fluid
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13
Q

in the glomerular capillaries

A
  • filter the fluid but not the protein

- causing an increase in protein concentration

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14
Q

at the end of glomerular capillaries

A
  • filters less fluid due to increase in protein concentration decreasing GFR
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15
Q

in the peritubular capillaries

A
  • more concentrated protein promotes more reabsorption
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16
Q

increase filtration fraction

A
  • increase net force promoting reabsorption
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17
Q

PBC bowman’s capsule pressure

force opposing filtration -

A
  • 8 mm Hg
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18
Q

pyBC

A
  • 0 mm Hg
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19
Q

PGC glomerular capillary pressure

force promoting filtration +

A
  • 45 mm Hg
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20
Q

pyGC

A
  • 24 mm Hg
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21
Q

net filtration formula

creating the GFR of 120ml/min

Study These Flashcards
A

PGC - pyGC - PBC = 13mm Hg

22
Q

glomerular capillary

Study These Flashcards
A
  • has a large surface area
23
Q

filtering membrane (permeable membrane, large surface area)

Study These Flashcards
A
  • capillary endothelial wall with large pores for protein pass thru, has negative pressure reason for not filtering the protein
  • glomerular basement membrane, negative charged
  • epithelial cell layer of podocytes
24
Q

negative pressure

Study These Flashcards
A
  • reason for not filtering the protein
25
damaging the filtering membrane
- will cause proteinuria | - nephrotic syndrome
26
FREELY filtered by the kidney | major electrolytes
- Na, Cl, K, HCO3
27
FREELY filtered by the kidney | metabolic waste
- glucose - amino acid - ketone bodies
28
FREELY filtered by the kidney | non natural substance
- inulin | - para-aminohippuric acid PAH
29
FREELY filtered by the kidney | lower weight proteins and peptides
- insulin - myoglobin - CORTISOL - TESTOSTERONE
30
NOT freely filtered
- albumin - plasma protein - bilirubin - thyroxine T4 - lipid soluble hormones - CORTISOL
31
OSMOLARITY OF THE FILTRATE
- 300 mOsm/L
32
tubular fluid conc./plasma | TF/P ratio
= 1.0 | substance if freely filtered in the bowman capsule
33
all freely filtered material has a ratio of
- TF/P= 1.0
34
ratio of .7, .5, .6
- plasma > TF | - no freely filtered
35
TF/P= 1.2
- TF > plasma - DISTRACTOR - IMPOSSIBLE
36
TF/P=1.0
- FREELY FILTERED
37
FILTRATION FRACTION | Na, K, Cl, HCO3, glucose
``` GFR/RPF (renal plasma flow) - GRF= 120 ml/min - RPF= 600ml/min normal ratio = .20 or 20% or 120 ml/min is filtered - 80% is not filtered or 480 ml/min ```
38
increase plasma concentration of glucose
- increase filtration >120ml/min
39
decrease plasma concentration of glucose
- same filtration 120ml/min
40
glomerular capillary pressure is proportional to increase GCP decrease GCP
- GFR - increase GFR - decrease GFR
41
plasma protein concentration is inverse
to GFR
42
AFFERENT CONSTRICTION DECREASE INCREASE NO CHANGE
- GF pressure - DECREASE - GFR - DECREASE - RPF renal plasma flow - DECREASE - FF - NO CHANGE
43
EFFERENT CONSTRICTION
- GF pressure -INCREASE - GFR - INCREASE - RPF renal plasma flow- DECREASE - FF -INCREASE
44
DECREASE OF FLOW in glomerular capillaries
- filter >
45
SYMPATHETIC stimulation to the kidney | AFFECTS AFFERENT ARTERIOLE MAINLY
- VASOCONSTRICTION of the arterioles - decrease GFR less fluid absorption - increase FF - force promoting reabsorption in the peritubular capillaries INCREASE
46
KIDNEY HAS NO
- PARASYMPATHETIC STIMULATION
47
ANGIOTENSIN II | mainly affects EFFERENT ARTERIOLES
- increase renal resistance w/o change in GFR - affecting afferent no change GCP - decrease plasma flow
48
ACE INHIBITOR | dilate EFFERENT ARTERIOLES
- decrease renal resistance - decrease GFR - increase renal plasma flow
49
GFR vs FILTER LOAD
GFR- filtered fluid into bowman capsule - volume per unit time ML/min FILTER LOAD- rate of filtering substance into bowman's capsule MG/min
50
filtered load
- GFR x plasma concentration of a substance
51
during PREGNANCY
- INCREASE GFR - INCREASE FILTER LOAD GLUCOSE (dissolve substance) - INCREASE PLASMA GLUCOSE CONCENTRATION - INCREASE ML/MIN causing overload of proximal tubule - glycosuria is normal in pregnancy

RENAL PHYSIOLOGY (9 decks)

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