GH

Question 1

GH

Answer 1

Structure: Peptide
Synthesis: De Novo
Storage: Vesicles
Release: Exocytosis
Transport: Mostly free; hydrophilic
Mechanism: 1TM Receptor (Tyr Kinase)

Question 2

What is GH substitution therapy?

Answer 2

hrGH: human recombinant growth hormone

Question 3

GH pathway

Answer 3

GHRH: Growth Hormone Releasing Hormone
↓+
Somatotrophs (Adenohypophysis)
↓+
Gs-signaling
↓+
GH: Growth Hormone

Question 4

IGF pathway

Answer 4

GHRH: Growth Hormone Releasing Hormone
↓+
GH: Growth Hormone
↓+
IGF I/II (Somatomedins)

Question 5

Where is IGF released?

Answer 5

Liver
Endocrine effect

Periphery
Auto/para-crine effect

Question 6

IGF

Answer 6

Structure: Peptide
Synthesis: De Novo
Storage: Vesicles
Release: Exocytosis
Transport: Mostly free
Mechanism: 1TM Receptor (Tyr Kinase)

Question 7

What’s NSILA??

Answer 7

Non suppressible insulin like activity

Question 8

GH Metabolic effect

Answer 8

Carbohydrates
↓ Glucose uptake
↑ Gluconeogenesis
↑ Glycogenolysis
* ↑ Blood-glucose levels

Lipids
↑ Lipolysis
↑ Ketogenesis
* ↑ Blood-FFA & Blood-Ketone levels

Amino Acids
↑ Amino acid uptake
↑ Protein synthesis
* ↓ Blood-AA levels

Question 9

IGF effects

Answer 9

↑ DNA/RNA Synthesis
↑ AA Uptake
↑ Protein Synthesis
↑ Cell Proliferation
↑ Collagen synthesis
↑ Sulphate incorporation (GAGs, PGs, etc.)

Question 10

GH stimulators

Answer 10

↓ Blood-glucose levels
↓ Blood-FFA levels
[AKA FASTING]
↑ Blood-AA levels

Deep sleep
Physical activity

Thyroid H.
Cortisol (low levels)
Serotonin
GHRH

Question 11

GH inhibitors

Answer 11

↑ Blood-glucose levels
↑ Blood-FFA levels
[AKA OBESITY]
↓ Blood-AA levels

Chronic stress (high cortisol levels)
GHIH (AKA somatostatin)