GI

Question 1

Which PPIs are most bioavailable?

Answer 1

Lansoprazole/dexlansoprazole and pantoprazole

Question 2

Which PPIs are available OTC?

Answer 2

Lansoprazole, esomeprazole,, and omeprazole

Question 3

What are the indications of PPIs?

Answer 3

PUD
GERD
Zollinger-Ellison Syndrome (gastronoma)
Prevent PUD in persons on long-term NSAID therapy (example: Vimovo)
Dyspesia/Heartburn

Question 4

What drug is the combination of naproxen and esomeprazole?

Answer 4

Vimovo

Question 5

When should patients be taken off or tapering begin of PPIs?

Answer 5

GERD or dyspepsia who are asymptomatic for 3 months and do not have other indications for being on a PPI

Question 6

Which drugs should not be given with PPIs?

Answer 6

H2 receptor Antagonists

Question 7

Why should PPIs and H2 antagonists be avoided in combination?

Answer 7

the extensive acid suppression therapy may decrease the absorption of nutrients such as vitamin B12, iron, and calcium which require an acidic environment to be absorbed in the stomach.

Question 8

What is the dosing for PCABs for healing of erosive esophagitis?

Answer 8

20 mg once daily for 8 weeks with maintenance 10 mg once daily for up to 6 months