GI - Acid Secretion Flashcards Preview

Phase II - Clinical Pharmacology and Therapeutics > GI - Acid Secretion > Flashcards

Flashcards in GI - Acid Secretion Deck (6)
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1

Give an example of a PPI.

Omeprazole, lansoprazole.

2

What is the mechanism of action of PPIs?

Bind to the H+/K+/ATPase of parietal cells and block it so it can't secrete acid.

3

What is the main side effects of PPIs?

Diarrhoea.

4

When should PPIs be administered and why?

30-60 minutes before breakfast or the largest meal of the day as they have delayed onset of action.

5

Give an example of a histamine 2 receptor antagonist.

Cimetidine, ranitidine.

6

What is the mechanism of action of H2RAs?

Competitively blocks binding of histamine to H2 receptors, therefore reduces secretion of action by blocking stimulation of H+/K+/ATPase proton pump.