GI drugs

Question 1

Which drug has some antimicrobial properties, weak antacid, anti-secretory and antiinflammatory to the GI tract?

Answer 1

Bismuth subsalicylate

Question 2

How does bismuth subsalicylate decrease gas production?

Answer 2

Binds hydrogen sulfide

Question 3

MOA of cisapride? Prokinetic that works well where?

Answer 3

MOA - 5HT4/serotonin AGOnist –> stimulates release of ach into the enteric NS; parasympathomimetic. Good prokinetic for the LES and colon. `

Question 4

MOA of cyproheptadine?

Answer 4

Serotonin antagonist

Question 5

MOA of domperidone?

Answer 5

D2 antagonist

Question 6

MOA of erythromycin in the GI tract?

Answer 6

Promotes motilin release; prokinetic

Question 7

MOA of famotidine

Answer 7

H2 receptory antagonist

Question 8

MOA of lactulose and magnesium salts??

Answer 8

Hyperosmotic laxatives; stimulate colon fluid and propulsive motility

Question 9

MOA of maropitant? Found in the central and peripheral NS associated with _____, which is asso. with pain and stress? SE?

Answer 9

NK-1 receptor antagonist. Associated with substance P. Possible SE; hyptension in renal failure, may prolong the QT interval

Question 10

MOA of metoclopramide? Uses?

Answer 10

D2 dopaminergic receptor antagonist in the CRTX and CNS; mixed 5-HGT3 antagonist and 5-HT4 agonist. Use: antiemetic and prokinetic

Question 11

MOA misoprostol?

Answer 11

PGE analogue

Question 12

MOA of octreotide? Effects of this drug?

Answer 12

Somatostatin analogue - somatostatin normally inhibits gastric, pancreatic and biliary secretions; prlongs GI transit time; decreased jejunal secretions

Question 13

MOA of omeprazole? In an acidic environment, what happens to omeprazole? Other uses?

Answer 13

Inhibits the H/K ATPase; In the acidic environment, omeprazole is activated to a sulphenamide derivative that binds irreversibly at the secretory surface of the parietal cells –> inhibits transport of H ions into the stomach. Also inhibits cytochrome P-450. Decreases CSF production.

Question 14

MOA of ondansetron?

Answer 14

5HT3/serotonin receptor ANTAgonist –> reduces the activity of the vaugs nerve which deactivates the vomiting center in the medulla oblangata.

Question 15

MOA of phenothiazine (chlorpromazine)? SE?

Answer 15

Alpha 2 adrenergic antagonist. Hyptension

Question 16

MOA of ranitidine? How does is stimulate motility?

Answer 16

H2 receptor antagonist. Stimulates motility by inhibiting acetylocholinesterases.

Question 17

MOA of somatostatin?

Answer 17

Blocks gastrin secretion

Question 18

MOA of simethicone?

Answer 18

Decreases gas bubble surface tension

Question 19

MOA of sucralfate?

Answer 19

Stimules PG synthesis from the gastric mucosa; offers mucosal protection by binding proteins

Question 20

MOA of sulfasalazine

Answer 20

Prostaglandin synnthestase inhibitor; antileukotriene

Question 21

What is Viokase?

Answer 21

Pancreatic enzyme concentrage of porcine origin (EPI).