GI hormones Flashcards
what is source of gastrin
G cells in antrum of the stomach
what is stimulus gastrin
Distension of stomach, vagus nerves (mediated by gastrin-releasing peptide), luminal peptides/amino acids
Inhibited by: low antral pH, somatostatin
what is action gastrin
Increases acid secretion by gastric parietal cells, pepsinogen and IF secretion, increases gastric motility, stimulates parietal cell maturatio
what is source CCK
I cells in upper small intestine
what is CCK stimulus
Partially digested proteins and triglycerides
what actions does CCK do
Increases secretion of enzyme-rich fluid from pancreas, contraction of gallbladder and relaxation of sphincter of Oddi, decreases gastric emptying, trophic effect on pancreatic acinar cells, induces satiety
what is usage of secretin
S cells in upper small intestine
what is secretin secretion
Acidic chyme, fatty acids
what secretin action
Increases secretion of bicarbonate-rich fluid from pancreas and hepatic duct cells, decreases gastric acid secretion, trophic effect on pancreatic acinar cells
what is source of VIP
Small intestine, pancreas
what is stimulus VIP
neural
what is action of VIP
Stimulates secretion by pancreas and intestines, inhibits acid secretion
what is source somastostanin
D cells in the pancreas & stomach
what is stimulis
Fat, bile salts and glucose in the intestinal lumen
what is action somastostin
Decreases acid and pepsin secretion, decreases gastrin secretion, decreases pancreatic enzyme secretion, decreases insulin and glucagon secretion
inhibits trophic effects of gastrin, stimulates gastric mucous production
