GI (MCQBank) Flashcards by Olumide Asake

Organism that doesn’t cause bloody diarrhoea

Enterobacter (Gram -, facultatively anaerobic, rod shaped)

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Organism that causes bloody diarrhoea

Salmonella
Shigella
Campylobacter jejuni
Yersinia enterolitica
E.coli
Entamoeba histolytica

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Smoking effect on Crohn’s VS UC?

Worsen Crohn’s.
Protective for UC.

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Age of onset for Crohn’s VS UC?

20-30 y/o for both?

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What is Jalan’s diagnostic criteria for toxic megacolon?

Radiographic evidence of colonic dilatation (>6cm)
Any 3 of: fever >38.5, tachycardia >120, leucocytosis >10.5, anaemia.
Any 1 of: dehydration, altered mental status, electrolyte abnormality, hypotension

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who gets referred for upper GI endoscopy if they present with dyspepsia?

> =55 y/o
or have ALARMS:
Anaemia
Loss weight unintentional
Anorexia
Recent onset of progressive symptoms
Malaena/Haematemesis
Swallowing problems

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commonest cause of LARGE rectal bleed for >60y/o

diverticular disease

(but overall, haemorrhoids is the most common cause of haematochezia - bleeding from the rectum)

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Non-surgical treatments of haemorrhoids

rubber band ligation (put at base of haemorrhoid -> becomes strangulated -> slough off)

injection sclerotherapy (phenol injected into submucosa -> induce fibrotic reaction -> obliterate haemorrhoid vessel ->atrophy)

infrared coagulation/photocoagulation

bipolar diathermy & direct current electrotherapy

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Surgical treatments of haemorrhoids

haemorroidectomy

stapled haemorrhoidectomy

haemorrhoidal artery ligation

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what diseases are associated with H.pylori?

peptic ulcer disease
MALT lymphoma
gastric adenocarcinoma
Menetrier’s disease (rare high-protein gastropathy with gross hypertrophy of gastric mucosa)
coronaritis (inflammation of coronary artery)
iron-deficiency anaemia

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Causes of acute pancreatitis

I GET SMASHED

Idiopathic
Gallstones
Ethanol
Trauma
Steroids
Mumps
Autoimmune
Scorpion
Hyperlipidaemia, Hypercalcaemia, Hypothermia
ERCP
Drugs: HIV (Didanosine, pentamidine), diuretics (furosemide, hydrochlorothiazide), chemo (L-asparaginase, azathioprine), oestrogen

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diarrhoea, weight loss, hyperglycaemia, flushing attack, widespread rash

Diagnosis?

Glucagonoma

The rash is necrolytic migratory erythema.

The 4 D - diarrhoea, diabetes, DVT, depression

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When palpating the left iliac fossa, there is pain in the right iliac fossa. ?diagnosis

Appendicitis

Rovsing’s sign

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Intermittent diffuse abdominal pain, worse after eating meals. Pain is worsening and patient lost weight. History of HTN and current smoker.

? Diagnosis (NOT peptic ulcer disease/cancer)

Chronic mesenteric ischaemia

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What is CRP? Where is it produced? What is the half-life?

C-reactive protein - acute phase protein
Produced by hepatocytes
half-life is 19 hours

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What is faecal calprotecti? How is it linked to exac of IBD?

inflammatory protein found in neutrophils, macrophages and monocytes
presence in faeces is directly proportional to neutrophil migration into GI tract
90% positive predictive value for endoscopically active Crohn’s.

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Haemorrhoids - what are the PR examination findings?

Nothing. The veins empty as the finger compresses them.

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Portal HTN causes
- pre-hepatic
- hepatic
- post-hepatic

Pre-hepatic
- congenital atresia or stenosis
- portal vein thrombosis (idiopathic, sepsis, malignancy, hypercoagulable state, pancreatitis)
- splenic vein thrombosis
- extrinsic compression - tumours

Hepatic
- Pre-sinusoidal: schistosomiasis, congenital hepatic fibrosis, early PBC, sarcoidosis, chronic active hepatitis, copper toxin
- Sinusoidal: cirrhosis, alcoholic hepatitis, vitamin A intoxication, cytotoxic drug
- Post-sinusoidal: sinusoidal obstruction syndrome or veno-occlusive disease

Post-hepatic
- constrictive pericarditis
- Budd Chiari syndrome
- IVC blockage : thrombosis, stenosis, tumour invasion

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Cancers that spread to liver

Colon
Stomach
Pancreas
Lung
Breast
Neuro-endocrine
Eye

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Who gets referred for 2ww for ?colorectal cancer?

> =40 with weight loss and abdo pain
=50 with unexplained rectal bleeding
=60 with iron-deficiency anaemia OR change in bowel habit
Anyone with positive faecal occult blood

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How to detect H.pylori?

Non-invasive test
- blood antibody test
- stool antigen test
- carbon urea breath test (14C or 13C) - MOST ACCURATE - patient will drink 14C or 13C labelled urea and then when bacterium metabolises this, we can test for carbon dioxide.

Invasive test
- endoscopy with CLO test (rapid urease test)
- histological examination
- microbial culture

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Causes of raised ALP in asymptomatic patient.

PS: ALP is released by liver, bone and placenta

Normal: growth spurts in adolescence, pregnancy (3rd trimester), age-related.

Drug causes: nitrofurantoin, phenytoin, erythromycin, disulfiram

Paget’s disease

Primary biliary cirrhosis, cholestasis, hepatic cancer

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Complications of gallstones

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Gallbladder
- biliary colic
- acute/chronic cholecystitis
- empyema
- mucocoele
- carcinoma

Bile ducts
- obstructive jaundive
- pancreatitis
- cholangitis

Gut
- gallstone ileus

Fatigue, pruritus, steatorrhoea, dry eyes and mouth, jaundiced, xanthelasma, enlarged spleen and liver. ?diagnosis

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PBC

The most common cause of - small bowel obstruction - large bowel obstruction

SBO: post-op adhesions, malignancy, corhn's, incarcerated hernias LBO: cancer

Difference between femoral VS inguinal hernia

Difference between - gallstone - cholecystitis - cholangitis

All have RUQ pain Cholecystitis: positive Murphy's sign (inhibit inspiration due to RUQ pain on palpation). also have systemic features with fever, raised WCC and CRP Cholangitis: Charcot's triad: RUQ pain, jaundice, swinging pyrexia. Also, low BP, decrease or loss of consciousness (Reynold's pentad)

SBP - how to diagnose - how to treat

Paracentesis (>250 cells/mm3) cephalosporin IV 3rd gen

What happens in Gilbert's disease?

decrease in activity of UDP-glucuronyl transferase Therefore, drugs that cannot be used: - atazanavir - indinavir - gemfibrozil - statins with gemfibrozil - irinotecan

AST and ALT raise - ?dignoses

AST>ALT: acute alcoholic hepatitis, acute viral hepatitis ALT>AST: acute hepatitis, obstructive jaundice

What is the Rockall scoring system?

ABCDE Age BP - shock Comorbidities such as HF, IHD, liver failure, renal failure, cancer Diagnosis such as mallory weiss tea, upper GI malignancy Evidence of bleeding Used to show the outcome risk after upper GI bleed (re-bleeding or mortality)

what vitamin does carcinoid tumour cause a deficiency in? as a result of the vitamin deficiency, what symptoms arise? as a result of the vitamin deficiency, what is this condition called?

Vitamin B3 (niacin) PS: carcinoid tumour creates a lot of serotonin from tryptophan metabolism. Niacin is derived from tryptophan - therefore with less tryptophan, you get less niacin. Dermatitis, Diarrhoea, Dementia Pellagra

4 days post-CABG. Not passed wind or stools. Abdo distended with vomit and loss of appetite. Absent bowel sounds. Xray shows distended small and large bowel loops ?diagnosis

Post-op ileus

Tx of post-op ileus

watchful waiting and supportive tx keep NBM and IV fluids +/- NG tube

Effects of deficiency of these vitamins: - vitamin A - vitamin B1, B2, B3, B5, B6, B12

Retinol (A) : night blindness, dry skin Thiamine (B1): beri-beri, wernicke korsakoff Riboflavin (B2): angular stomatitis Niacin (B3): pellagra Panthothenate (B5): dermatitis, enteritis, alopecia, adrenal insufficiency Pyridoxine (B6): convulsions, hyperirritability Cobalamin (B12): macrocytic megaloblastic anaemia, glossitis, subacute cord degeneration, optic neuropathy, paraesthesia

what is another name for pharyngeal pouch?

Zenker diverticulum

Jaundice, pale stools, dark urine. Bilirubin level 35, ALP 300. USS showed stone obstructing common bile duct & dilating to 13mm. ?Management

ERCP with sphinterotomy High risk for cholecystectomy if: - recent cholangitis - recent acute pancreatitis - abnormal LFTs (ALP >2x) - dilated CBD >10mm

Risk factors for gastric cancer

- increasing age ie >55 - men - poor socio-economic status - H.pyleori - low fresh fruit/veg - high salt & preservatives - smoking - atrophic gastritis, pernicious anaeamia, post-gastrectomy - Blood group A

Tx of anal fissure: Acute VS Chronic

ACUTE 1st line: high fibre diet, adequtae fluid intake, stiz bath, laxative (bulk-forming -> lactulose) - lubricants such as petroleum jelly - topical anaesthetics - analgesia (topical analgesia (lidocaine 5% ointment) CHRONIC try the above techniques first - topical GTN BD for 6-8 weeks - if not effective after 8 weeks -> ?sphincterotomy or botox infection,

First line tx of proctatitis

Rectal aminosalicylate - suppositories or enemas

Serologic tests to differentiate UC from Crohn's.

UC : p-ANCA positive Crohn's: ASCA antibodies

Names of all vitamin B

B1 - thiamine B2 - riboflavin B3 - niacin B6 - pyridoxine B9 - folic acid B12 - cyanocobalamin

what is mirizzi syndrome

common hepatic duct obstruction caused by extrinsic compression from an impacted stone in the cystic duct or infundibulum of the gallbladder

modified glasgow score for pancreatitis

>=3 means pancreatitis

atrophic glossitis, iron deficiency anaemia, oesophageal webs/strictures ?diagnosis

plummer vinson sydrome AKA Paterson-Brown-Kelly syndrome, sideropenic dysphagia, sideropenic nasopharyngopathy, waldenstrom-kjellberg syndrome PC: painless, intermittent dysphagia- usually solid food Tx: iron replacement, endoscopic dilatation or argon plasma coagulation therapy

how to diagnose spontaneous bacterial peritonitis from paracentesis?

total polymorphonuclear neutrophils in ascites >250cell/microL. tx: 3rd generation cephalosporin

what drug causes raised ALP?

nitrofurantoin phenytoin erythromycin disulfiram

metabolic causes of constipation

hypercalcaemia diabetes (with autonomic neuropathy) hyperparathyroidism hypermagnesaemia hypokalaemia hypothyroidism uraemia

which diarrhoea organism is linked with reactive arthritis and Guillain Barre syndrome?

campylobacter

which diarrhoea organism is linked with haemolytic uraemic syndrome?

EHEC

patient with stone obstructing CBD - who gets ERCP+sphincterotomy and who gets cholecystectomy?

Cholecystectomy: - recent cholangitis - recent acute pancreatitis - abnormal LFT (ALP >2x normal) - dilated CBD >10mm

another name for pharyngeal pouch

zenker diverticulum

how to calculate the units of alcohol according to the % on bottle?

[volume (ml) x %ABV]/1000 For example (to calculate one week): 2 pints of 4% lager every night and 2 standard sized glasses of 12% wine on friday and saturday: [7 x 2 x (568 x 4)/1000] + [2 x 2 x (175 x 12)/1000] = 40 units

diarrhoea with facial flushing ?diagnosis

glucagonoma

for patients who have IBD for >10 years, they are at risk of colorectal cancer. what is the surveillance mechanism?

colonoscopy and multiple biopsies

GI (MCQBank) Flashcards

(56 cards)