GI Misc Flashcards

1
Q

H. pylori treatment abx in peptic ulcers?

A
  • Omeprazole
  • Metronidazole
  • Clarithromycin
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2
Q

How do to investigate H. Pylori in ulcers?

A

Stool antigen test, C13 urea test and endoscopy

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3
Q

Name PPi. what does it do

A

lansoprazone. long term reduction in HCl acid release

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4
Q

Name a H2 blocker. what do they do

A

rantidine. suppress gastric acid release

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5
Q

what obstructions can lead to appendicitis?

A

food matter, adhesions, lymphoid hyperplasia which cause mucosal secretions and cause intra-luminal pressure to rise

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6
Q

Appendicitis presentation?

A
  • Abdo pain central -> RIF
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Pt prefers to have legs bent, not lying straight - guarding
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7
Q

Peritonitis -causes?

A

perfortation of GI tract. eg. dialysis, post op, spontaneous bacterial, bile leak, pregnancy blood rupture

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8
Q

Peritonisis - symptoms

A

tenderness, pain, nausea, chills, rigor, vomit, fever, shoulder pain, silent abdomen

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9
Q

Why do an xray for peritonitis /

A

ERECT X-RAY. look for air under the diaphram. also location of infection using USS.

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10
Q

What is diverticular disease? Who is it n=most ocmmon it?

A

Diverticula and complications (eg. diverticulitits - inflammation). most common in older population and low fibre diets

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11
Q

What abx do you give for management of Diverticular disease?

A

ciprofloxacin & metronidazole

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12
Q

Acute diverculitis?

A

sudden attack of swlling in diverticula. left ileac fossa region pain, fever, tachycardia

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13
Q

Symptoms of diverticular disease?

A

Asymptomatic in 95% of cases! Symptoms
that do occur relate to luminal narrowing; pain, constipation,
bleeding or diverticulitis. Severe cases; left iliac fossa pain,
fever, nausea.

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14
Q

What causes diverticular disease?

A

Unknown. ?Related to a low fibre diet -> Increased

intracolonic pressure -> herniation at sites of weakness? most common in older people

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15
Q

difference between direct and indirect inguinal hernia?

A

Direct - medial to IEA in Heissenback triangle. only passes through superficial inguinal ring
indirect - most common. lateral to IEA. passes through deep and superficial inguinal rings.

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16
Q

How do you treat crohn’s?

A

stop smoking,
Mild attacks: Prednisolone
Severe: IV hydrocortisone

5-ASA analogues (mesalazine) -> reduces relapses
Corticosteroids -> induce remission/treat relapses
Surgery

17
Q

is crohn’s improved by smoking?

A

no. UC is decreased by smoking. Crohn’s is increased.

18
Q

What does GALS stand for in crohns?

A

Only GALS can be CROHNS
Granulomas

All Layers and Levels

Skip Lesions

19
Q

Why do an x-ray in IBS?

A

to exclude toxic dilation of colon and to see the progression of either UC or crhons

20
Q

What are the HCV antivirals?

A

Velpatasvir/sofosbuvir

21
Q

What are the symptoms of encephalopathy? (brain damage)

A

confusion, drowsiness, disorientated

22
Q

Treatment for paracetamol overdose?

A

N-Acetyl-Cysteine

23
Q

What is the flapping tremour?

24
Q

Symptoms of fulminant liver failure?

A

Encephalopathy – confusion, drowsiness, disorientated
Asterixis
Jaundice
Can have presentation of sepsis

25
Treatment for encephalopathy?
lactulose
26
what are the chronic liver conditions?
Infectious (Hep B, Hep C) Autoimmune (AIH, PSC) Metabolic (iron – haemochromatosis, copper – Wilson’s, alpha-1-antitrypsin) Alcoholic liver disease Non Alcoholic Fatty Liver Disease (NAFLD)
27
Name a NOAC?
apixibam
28
Symptoms of overanti-coagulating
burising, bleeding, melena, epistaxis, haematemesis, haemoptysis,
29
HCC - liver cancer? summar?
risks - hep B, hep C, cirrhosis, Presentation - right hypochondric pain, anorexia, fatigue, jaundice, weight loss, ascite Dx - contrast CT showing mass, liver biopsy, mets - liver, bone, lungs
30
Acute pancreatitis summary? causes, presentaton, signs, bloods, urinalysis, scoring system/ treatment? complication
I GET SMASHED - causes Presentation - anorexia, epigastric pain radiates to back and relieved by sitting forward, jaundice, guarding and rigidity,nausea, signs - cullens sign and grey turner's bloods - increased amylase, lipase and CRP urinalysis - increased amylase USS - gall stones, contrast CT Glasgow scoring system, APACHE II TX- NSAIDs, metronidazole, fluids, O2, ABX, analgesia complications - DM
31
Haemochromatosis summary?
autosomal recessive condition. HFE mutation on chromosome 6 causes a mutation on the transferrin receptor leading to increased absorption and deposits. SX - bronze diabetes, hepatomegaly, tiredness, cardiac failure, cirrhosis, cardiomyopathy signs - increased iron and ferritin TX - venesection and desferrioxamine
32
Wilson's disease summary?
Children - cirrhosis adults - tremour/dysphagia, kayser-fleischer rings in eyes. Cause - autosomal recesive condition on chomosom 13 causing impaired excretion of copper in bile. copper in liver and CNS IX - serum caeruloplasmin, biopsy for cirrhosis ans hep MRI - cerebella/basal ganglia degeneration Tx - Penicillamine to excrete copper, Reduce copper intake
33
Alpha-1-anti-trypsin deficiency? summary
autosomal recessivelcondition on chromosome 14. accumulation of alpha-1-antitrypsin in hepatocytes and lack of it in serum causing lack of protease inhibition in alveoli causing damage to alveoli and subsequent emphysema. Tx - manage COPD ad cirrhosis and liver transplant children - cirrhosis adults - SOD, dysponoea Low serum alpha-1-anti-trypsin.
34
Biliary colic?
gallstone impacted in the gallbladder neck and temporarily dislodged into the gallbladder
35
Acute cholecystitis?
Gallstone stuck in gallbladder neck and causes inflammation due to obstruction in drainage. SX -seveere RUQ pai, vomitting, nausea, fever, NO JAUNDICE