GI Pharm Flashcards by Elizabeth Mertens

Q

Benign ulcers

A

Normal acid production, weak mucosal barrier

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Q

Malignant ulcers

A

Increased acid production, normal mucosal barrier

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Q

H2 receptor blockers

A

-tidine

Cimetidine, famotidine, ranitidine, nizatidine

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Q

PPIs

A

-prazoles

Omeprazole, esomeprazole, rabeprazole, lansoprazole, pantoprazole

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Q

Prostaglandin

A

Misoprostol

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Q

Prostaglandin MOA

A

Maintains mucosal barrier (via COX pathway)

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Q

Prostaglandin use

A

PUD and GERD caused by NSAID injury

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Q

Anticholinergic

A

Pirenzepine

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Q

Mucosal protective agents

A

Sucralfate and chelated bismuth

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Q

Triple therapy

A

PPI, moderate antibiotic, strong antibiotic

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Q

Quadruple therapy

A

PPI, moderate antibiotic, strong antibiotic, chelated bismuth

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Q

Treatment for mild Crohn’s

A

-salazines

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Q

Treatment for moderate Crohn’s

A

Prednisolone

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Q

Treatment for active and chronic Crohn’s

A

Thiopurines, MTX

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Q

Laxative MOA

A

Increase diameter of intestinal lumen

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Q

Laxative classes

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A

Bulking
Osmotic
Stool softener
Stimulant

Q

Bulk laxatives

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A

Non-digestible fiber

Q

Osmotic laxatives

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A

Non-digestible sugars/alcohols
Salts
PEG

Q

Stool softeners

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A

Docusate sodium

Q

Stimulant

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A

Castor oil
Senna
Bisacodyl
Lubiprostone

Q

Anti-diarrheal MOA

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A

Stimulate opioid receptors–>reduce motility

Q

Anti-diarrheals

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A

Diphenoxylate (+atropine)

Loperamide (doesn’t cross BBB)

Q

Anti-flatulent

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A

Simethicone (detergent)

Q

Anti-emetic

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A

M1 blocker
H1/D2 blocker
5-HT3 blocker

M1 blocker

Scopolamine

H1/D2 blockers

Phenothiazines

5-HT3 blockers

Ondansetron, granisetron