Glomerular disease Flashcards
what are the types of proteinuria
glomerular - nephrotic
tubular
overflow
what is glomerular injury resulting in excess loss of proteins in urine
nephrotic syndrome
What is minimal change disease
idiopathic, m/c in kids**
glomerulus anatomically appears normal - thinning of podocyte food processes - loss of negatively change - increased permeability - proteinuria
what is membranoproliferative glomerulonephritis
associated with complement activation, can be familial
thickening of glomerular basement membrane associated with deposits of inflammatory proteins
- proteinuria
what is membranous nephropathy
autoimmune response to antigen
typically associated with Hep B, C, SLE
thickening of rht GBM, antibody deposition - increased permeability - proteinuria
what is focal segmental glomerulosclerosis
idiopathic, can be associated with other disease processes
thinning of podocytes, hyaline deposits in mesangial cells and endothelial cells, increased pore size - proteinuria and fibrosis
what is secondary nephrotic syndrome
systemic disease causing glomerular dysfunction
what can lead to secondary nephrotic syndrome
DM
amyloidosis
SLE
IgA vasculitis
infection
malignancies
vascular disorders
what is Alport syndrome
basement membrane collagen disorder resulting in problem with the glomerular epithelium
what is the presentation of nephrotic syndrome
proteinuria - edema, infection
hypoalbuminemia - edema
hyperlipidemia - atherosclerosis
lipiduria - fati in urine
low vitamin D - low calcium, osteopososis
hypothyroidism
what is inflammation within the mesangium due to antigen deposition
nephritic syndrome
what is associated with hematuria with RBC casts and less proteinuria
nephritic syndrome
what is nephritic syndrome often associated with
infection (Hep B&C, post=strep glomerulonephritis) autoimmune infection
what is acute proliferative nephritic syndrome
post infectious
associated with Group A step (kids), staphococcus (adults)
IgG and complement deposit in the subepithelial areas
