Glomerular Diseases

Question 1

Focal

Answer 1

<50% of glomeruli are involved

Question 2

Diffuse

Answer 2

> 50% of glomeruli are involved

Question 3

Proliferative

Answer 3

Hypercellular glomeruli

Question 4

Membranous

Answer 4

Thickening of glomeruli basement membrane

Question 5

Primary Glomerular Disease

Answer 5

Involves only glomeruli, a primary disease of the kidney

Question 6

Secondary Glomerular Disease

Answer 6

Involves glomeruli and other organs, Ex. SLE and diabetic nephropathy

Question 7

List of nephritic syndrome

Answer 7

acute poststreptococcal glomerulonephritis; rapidly progressive glomerulonephritis; Berger Dx (IgA glomerulonephropathy); Alport

Question 8

List of nephrotic syndrome

Answer 8

Focal segmental glomerulosclerosis; membranous nephropathy; minimal change disease; amyloidosis; Diabetic Glomerulonephropathy

Question 9

Both Nephritic and Nephrotic

Answer 9

Diffuse proliferative glomerulonephritis & Membranoproliferative glomerulonephritis

Question 10

Massive prOteinuria (>3.5g/day) frothy urine, hyperlipidemia, fatty casts, edema

Answer 10

NephrOtic Syndrome

Question 11

Segmental sclerosis and hyalinosis

Answer 11

Focal Segmental Glomerulosclerosis

Question 12

Effacement of foot processes (name 2)

Answer 12

Focal Segmental Glomerulosclerosis & Minimal Change Disease

Question 13

Blacks & Hispanics, HIC, sickle cell, heroin-abuse, massive obesity, IFN tx

Answer 13

Focal Segmental Glomerulosclerosis

Question 14

Diffuse capillary and GBM thickening on light microscopy

Answer 14

Membranous Nephropathy

Question 15

Immune complex deposition. Nephrotic presentation of SLE.

“spike and dome”

Answer 15

Membranous Nephropathy

Question 16

Most common cause of primary nephrotic syndrome in Whites

Answer 16

Membranous Nephropathy

Question 17

Antibody to Phospholipase A2 receptor; NSAIDs, penicillamine, HBV, HCV, SLE, or solid tumor

Answer 17

Membranous Nephropathy

Question 18

Normal glomeruli, may be associated with Hodgkin Lymphoma (reed-sternberg cytokine mediated)

Answer 18

Minimal Change Disease

Question 19

Nephrotic Syndrome triggered by recent infection, immunization, or immune stimulus

Answer 19

Minimal Change Disease

Question 20

Excellent response to steroids

Answer 20

Minimal Change Disease

Question 21

Congo red stain with apple-green biregringence

Answer 21

Amyloidosis

Question 22

Tram-track appearance due to GBM splitting caused by mesangial ingrowth

Answer 22

Type I membranoproliferative glomerulonephritis

Question 23

Intramembranous immune complex deposits “dense deposits”

Answer 23

Type II membranoproliferative glomerulonephritis

Question 24

MPGN Type I is associated with

Answer 24

HepB and C

Question 25

MPGN Type II is assoicated with

Answer 25

C3 nephritic factor which stabilizes C3 nephritic factor decreasing C3 serum

Question 26

Kimmelstiel-Wilson lesion

Answer 26

Diabetic Glomerulonephropathy, eosinophilic nodular glomerulosclerosis

Question 27

Nonenzymatic glycosylation of efferent arterioles

Answer 27

Increases GFR and causes mesangial expansion; associated with diabetic glomerulonephropathy

Question 28

Inflammatory process of nephrons that leads to hematuria and RBC casts. Associated with azotemia, oliguria, HTN, proteinuria <3.5g/day

Answer 28

Nephritic Syndrome

Question 29

Starry sky granular appearance and lumpy bumpy IgG, IgM, and C3 deposition along GBM and mesangium

Answer 29

Acute Post-streptococcal glomerulonephritis

Question 30

Subepithelial Immune Complex Humps

Answer 30

Acute Post-streptococcal glomerulonephritis

Question 31

~2weeks after group A streptococcal infection

Answer 31

Acute Post-streptococcal glomerulonephritis

Question 32

Acute Post-streptococcal glomerulonephritis hypersensitivity

Answer 32

HS III

Question 33

Peripheral and periorbital edema, dark urine and HTN

Answer 33

Acute Post-streptococcal glomerulonephritis

Question 34

anti-DNase B titers and decreases complement levels

Answer 34

Acute Post-streptococcal glomerulonephritis

Question 35

crescent moon

Answer 35

rapidly progressive glomerulonephritis

Question 36

Goodpasture syndrome

Answer 36

looks like rapidly progressive glomerulonephritis; type II HS

Question 37

Hematuria and Hemoptysis

Answer 37

Goodpasture Syndrome; RPGN

Question 38

Wire looping of capillaries

Answer 38

Diffuse proliferative glomerulonephritis

Question 39

Subendothelial and sometimes intramembranous IgG-based immune complexes often with C3 deposition

Answer 39

Diffuse proliferative glomerulonephritis

Question 40

IgA-based IC deposits in mesangium seen with henoch-Schonlein purpura

Answer 40

IgA nephropathy (Berger Disease)

Question 41

episodic hematuria with RBC casts; often with flares of URI or acute gastroenteritis

Answer 41

IgA nephropathy (Berger Disease)

Question 42

Muated Type IV collagen

Answer 42

Alport Syndrome

Question 43

Glomerulonephritis, deafness, and less commonly, eye problems

Answer 43

Alport Syndrome

Question 44

MPO-ANCA

Answer 44

Microscopic polyangiitis

Question 45

PR3-ANCA

Answer 45

Granulomatosis with polyangiitis (Wegener)

Question 46

c-ANCA

Answer 46

Granulomatosis with polyangiitis (Wegener)