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Flashcards in Glomerular Diseases Deck (27):
1

Mutation in this gene causes FSGS in adulthood

TRPC6

2

Gross hematuria may be seen in

IgA nephropathy
Sickle cell diease

3

Pathologic equivalent of the clinical presentation of RPGN

Cresentic Glomerulonephritis

4

Renal Biopsy in Poststreptoccal Glomerulonephritis

Hypercellularity of mesangial and endothelial cells
Glomerular infiltrates of PMN
Granular deposits of IgG, IgM, C3, c4, c5-9
Subepithelial deposits “humps”

5

Classic Presentation of Post Streptococcal Glomerulonephritis

Hematuria
Pyuria
Red blood cell casts
Edema
Hypertension
Oliguric renal failure

6

Most common clinical sign of renal disease in Lupus Nephritis

Proteinuria

7

Class I Lupus Nephritis

Normal Glomerular Histology by any technique or normal light microscopy with minimal mesangial deposits on electron microscope

8

Class II Lupus Nephritis

Mesangial Immune complexes with mesangial PROLIFERATION

9

Class III lupus Nephritis

Focal Nephritis
Focal endocapillary with extracapillary proliferation with focal subendothelial immune deposits and mesangial expansions

10

Class IV Nephritis

Diffuse nephritis
Diffuse endocapillary with =/w/o extracapillary proliferation with diffuse subendothelial immune deposits and mesangial alterations

11

Class V

Membranous nephritis
Thickened basement membrane with diffuse subepithelial immune deposits

12

Class VI

Sclerotic nephritis
Global sclerosis of nearly all glomerular capillaries

13

Pulmonary renal syndrome presents as lung hemorrhage and glomerulonephritis involving collagen IV (alpha 3NC1 domain)

Goodpasture syndrome

14

HSP is different from IgA nephropathy in that

there is prominent systemic symptoms, younger age (<20 years old), preceding infection and abdominal complaints

15

2 most common presentation of IgA nephropathy

1. Recurrent episodes of Macroscopic hematuria during or immediately following an upper respiratory infection often accompanied by proteinuria
2. Persistent asymptomatic microscopic hematuria

16

Treatment of IgA nephropathy

No consensus
ACE inhibitors
Tonsillectomy
Steroid therapy
Fish oil

17

What are the two types of antibodies of ANCA small vessel vasculitis

Anti-proteinase 3 (PR3)
anti-myeloperoxidase (MPO)

18

Clinical Presentation of Granulomatosis with Polyangiitis

Fever, Purulent rhinorrhea, nasal ulcers, sinus pain, polyarthralgia/arthritis, cough, hemoptysis, shortness of breath, microscopic hematuria
0.5-1 g/24 hr proteinuria

19

Difference between Microscopic Polyangiitis and Granulomatosis with Polyangiitis

absence of granulomas in vasculitis in microscopic polyangiitis

20

Small vessel vasculitis
peripheral eosinophilia, cutaneous purpura, mononeuritis, asthma, allergic rhinitis

Churg Strauss Syndrome

21

Type of MPGN commonly associated persistent hepatitis C infection, autoimmune disease with note of tram-tracking

TYPE I MPGN

22

Classical Presentation of Nephrotic Syndrome

Heavy Proteinuria, minimal hematuria
Hypoalbuminemia
Hypercholesterolemia
Edema
Hypertension

23

Presentation of FSGS

hematuria
Hypertension
any level of proteinuria

24

Factors associated with poor outcome in FSGS

African american
Nephrotic range proteinuriia
Renal insufficiency

25

Secondary causes of FSGS

Viruses: HIV/Hepatitis B/Parvovirus
Hypertensive nephropathy
Reflux nephropathy
Cholesterol emboli
Drugs: Heroin/Analgesics/Pamidronate
Oligomenaphronia
Renal dysgeneis
Alport syndrome
Sickle cell disease
Lymphoma
Radiation nephritis

26

Associated diseases with Membranous Glomerulonephritis

malignancy (solid tumors of the breast, lung, colon)
Infection ( Hepatitis B, Malaria, schistosomiasis)
Rheumatologic disorders ( SLE, RA)

27

Subepithelial deposits

Membranous Glomerulonephritis