Glomerular Diseases

Question 1

causes of membranous nephropathy

Answer 1

primary: Ab to PLP A2 receptor (IgG)
secondary: drugs (NSAIDS, penicillamine, gold), infection (Hep, syphilis), SLE, tumours

Question 2

subENDOthelial humps (2)

Answer 2

• diffuse PROLIFERATIVE
• membranoPROLIFERATIVE GN

ENDO = PROLIFERATIVE

Question 3

nephrotic diseases

Answer 3

• diabetic nephropathy
• FSGS
• minimal change
• membranous nephropathy
• amyloidosis

Question 4

nephrotic syndrome

Answer 4

• proteinuria!!
• low albumin
• edema
• low antithrombin
• risk of infection
• high lipids (liver makes them to increase oncotic pressure)
• frothy urine

Question 5

efface peodocytes

Answer 5

minimal change

FSGS

Question 6

types of RPGN

Answer 6

1: anti-GBM (linear): Goodpasture
2: immune complex (lumpy bumpy)
3: pauci-immune (NO Ig or complement) - with C-ANCA or p-ANCA

Question 7

spike and dome

Answer 7

membranous nephropathy (subepithelial)

Question 8

GRANULAR immune complex (3)

Answer 8

• membranous nephropathy
• post-strep GN
• diffuse proliferative (SLE)

Question 9

p-ANCA

Answer 9

RPGN + microscopic polyangiitis

Question 10

most common nephrotic syndrome in AA and Hispanics

Answer 10

FSGS

Question 11

subEPIthelial humps (2)

Answer 11

• membranous nephropathy

- post-strep GN

Question 12

both nephritis + nephrotic

Answer 12

• diffuse PROLIFERATIVE GN (SLE)

- membranoPROLIFERATIVE GN

Question 13

IgG/IgM immune complexes (LOW complement levels) (4)

Answer 13

RPGN
post-strep GN
diffuse proliferative GN (SLE)
MPGN

Question 14

nephritic syndrome

Answer 14

• light proteinuria
• hematuria
• RBC casts
• azotemia (BUN, Cr increased)
• oliguria

Question 15

wire loops

Answer 15

diffuse proliferative (SLE)

Question 16

deposit fibrin

Answer 16

Goodpasture (RPGN crescent)

Question 17

pharynx or skin infection

Answer 17

post-strep GN

Question 18

fibrin

Answer 18

RPGN

Question 19

triggers of minimal change disease

Answer 19

infection
immunization
immune stimulus
insect bit
NSAID

Question 20

nephritic diseases

Answer 20

• post-strep GN
• RPGN
• membranoproliferative GN
• IgA nephropathy
• Alport

Question 21

tram track

Answer 21

MPGN (mesangium grows in between BM)

Question 22

C1q

Answer 22

MPGN

Question 23

c-ANCA

Answer 23

RPGN + GPA (Wegener)

Question 24

basket-weave

Answer 24

Alport

Question 25

LINEAR immune complex (1)

Answer 25

RPGN/crescent/Goodpasture | type I: anti-GBM

Question 26

peripheral, periorobital edema, tea urine, HTN

Answer 26

acute poststrep GN

Question 27

lumpy bumpy in mesangium

Answer 27

post-strepGN

Question 28

can't see cant pee cant hear a bee

Answer 28

alport (x-linked)

Question 29

NORMAL complement level (and immune complex deposition)

Answer 29

IgA nephropathy

Question 30

RPGN crescents are made of

Answer 30

``` fibrin plasma proteins glomerular perital cells monocytes m-phages ```

Question 31

types of MPGN

Answer 31

type I: Hep B, C, SLE, subacute bacterial endocarditis (subENDOthelial deposits) type II: C3 nephritic factor (deposit in membrane) tramtrack --> mesangial grows in between BM

Question 32

Ab to GBM

Answer 32

GOodpasture

Question 33

mesangium (2)

Answer 33

- IgA nephropathy | - diabetic neprhopathy

Question 34

affects BM (3)

Answer 34

- MEMBRANous nephropathy - MEMBRANOproliferative GN MPGN) - diabetic nephropathy (thick GBM)

Question 35

respiratory or GI infection, or spontaneous

Answer 35

IgA nephropathy

Question 36

segmental sclerosis + hyalinosis

Answer 36

FSGS

Question 37

Hep B, C

Answer 37

MPGN

Question 38

subacute bacterial endocarditis

Answer 38

MPGN

Question 39

PLP A2

Answer 39

membranous nephropathy

Question 40

penicillamine, NSAIDs

Answer 40

membranous nephropathy

Question 41

SLE (not diffuse SLE)

Answer 41

membranous nephropathy