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R - renal (Rachel) > glomerulonephritis > Flashcards

Flashcards in glomerulonephritis Deck (15)
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1

what is nephritic syndrome and what are the features of it

collection of symptoms with inflammatory underlying cause - PHAROH
proteinuria
haematuria
azotaemia (uraemia)
RBC casts
oliguria
hypertension

2

what is nephrotic syndrome and what are the features of it

collection of symptoms with no specific underlying cause - PHHHO
proteinuria >3g/day
hypalbuminaemia
hyperlipidaemia
hypercholesterolemia
oedema

3

what types of glomerulonephritis are nephritic

IgA nephropathy
Anti-GBM/goodpasture
post-streptococcal
rapidly progressive

4

what types of glomerulonephritis are nephrotic

minimal change disease
membranous nephropathy - most common
focal segmental glomerulosclerosis
membranoproliferative

5

how is most glomerulonephritis treated

blood pressure control with ARB, ACEi
immunosuppression

6

what is IgA nephropathy

IgA deposits in BM with mesangial proliferation
can have purpuric rash
nephritic

7

what is anti-GBM/goodpasture glomerulonephritis

anti-GBM attack basement membrane in the kidneys and lungs
renal failure + haemoptysis
nephritic

8

what is a differential diagnosis for renal failure + haemoptysis

polyangiitis with granulomatosis/wegener's
ANCA associated disease

9

what is rapidly progressive glomerulonephritis

crescentic glomerulonephritis on biopsy
acute presentation of nephritis
nephritic

10

what is post-streptococcal glomerulonephritis

happens 10-21 days after infection - usually tonsillitis or impetigo
usually under 30s
IgG deposits
treat with antibiotics
nephritic

11

what is minimal change glomerulonephritis

common in kids
sudden onset oedema
give prednisolone

12

what is membranoproliferative glomerulonephritis

immune complex deposits in BM

13

what is focal segmental glomerulosclerosis

scarring and sclerosis of glomerulus
high steroid resistance

14

what is membranous nephropathy

most common nephrotic GN
IgG and complement deposits in BM
secondary to malignancy, rheumatic diseases, NSAIDs
bimodal peak in 60s and 20s

15

how can you diagnose a specific type of glomerulonephritis

by renal biopsy