Flashcards in glomerulonephritis Deck (15)
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1
what is nephritic syndrome and what are the features of it
collection of symptoms with inflammatory underlying cause - PHAROH
proteinuria
haematuria
azotaemia (uraemia)
RBC casts
oliguria
hypertension
2
what is nephrotic syndrome and what are the features of it
collection of symptoms with no specific underlying cause - PHHHO
proteinuria >3g/day
hypalbuminaemia
hyperlipidaemia
hypercholesterolemia
oedema
3
what types of glomerulonephritis are nephritic
IgA nephropathy
Anti-GBM/goodpasture
post-streptococcal
rapidly progressive
4
what types of glomerulonephritis are nephrotic
minimal change disease
membranous nephropathy - most common
focal segmental glomerulosclerosis
membranoproliferative
5
how is most glomerulonephritis treated
blood pressure control with ARB, ACEi
immunosuppression
6
what is IgA nephropathy
IgA deposits in BM with mesangial proliferation
can have purpuric rash
nephritic
7
what is anti-GBM/goodpasture glomerulonephritis
anti-GBM attack basement membrane in the kidneys and lungs
renal failure + haemoptysis
nephritic
8
what is a differential diagnosis for renal failure + haemoptysis
polyangiitis with granulomatosis/wegener's
ANCA associated disease
9
what is rapidly progressive glomerulonephritis
crescentic glomerulonephritis on biopsy
acute presentation of nephritis
nephritic
10
what is post-streptococcal glomerulonephritis
happens 10-21 days after infection - usually tonsillitis or impetigo
usually under 30s
IgG deposits
treat with antibiotics
nephritic
11
what is minimal change glomerulonephritis
common in kids
sudden onset oedema
give prednisolone
12
what is membranoproliferative glomerulonephritis
immune complex deposits in BM
13
what is focal segmental glomerulosclerosis
scarring and sclerosis of glomerulus
high steroid resistance
14
what is membranous nephropathy
most common nephrotic GN
IgG and complement deposits in BM
secondary to malignancy, rheumatic diseases, NSAIDs
bimodal peak in 60s and 20s
15
