Glomerulonephritis Flashcards
(34 cards)
What is the basic filtering unit of the kidney?
Glomerulus
What term is defined as damage to the major components of the glomerulus (podocyte, GBM, capillary endothelium, mesangium)?
Glomerular disease
What is primary glomerular disease?
Glomerular injury limited to the kidney
What is secondary glomerular disease?
Renal abnormalities result from systemic disease
Focal glomerular disease is considered what?
< 50% of glomeruli involved
In general, hematuria should make you think of nephritic disease or nephrotic disease?
Nephritic disease
In general, proteinuria should make you think of nephritic disease or nephrotic disease?
Nephrotic disease
Glomerular disease limited to the kidney is primary or secondary disease?
Primary
Glomerular disease due to systemic disease is primary or secondary disease?
Secondary
Disease that present in the nephritic spectrum and signify inflammatory process causing renal dysfunction is what?
Glomerulonephritis
Deposition of immune complexes into the glomerulus is etiology for what glomerulonephritis or nephrotic syndrome?
Glomerulonephritis
Dysmorphic RBCs, RBC casts, proteinuria < 3.0 and smokey/cola color urine are sx for what disease?
Nephritic syndrome
Cresenteric formation, systemic sx, RBC casts and proteinuria are concerning for what disease?
Rapidly progressive glomerulonephritis (RPGN)
IgA nephropathy (aka Berger disease) is the most common etiology for what?
Primary glomerular disease Peak incidence 2nd/3rd decades of life Post URI by 1-2 days
Glomerular disease etiology that is more common in peds and onset 1-3 wks post GAS infection is what?
Poststreptococcal GN (PSGN)
What labs do you order for Poststreptococcal GN (PSGN)?
ASO titers
What GN etiology has onset post URI, + IgA containing immune complexes?
IgA vasculitis (HSP)
Tetrad for HSP?
- Palpable purpura 2. Arthralgia 3. Abd pain 4. Renal disease
Glomerular nephritis + pulmonary hemorrhage is concerning for what?
Good pasture syndrome
Good pasture disease has what 3 components?
- GN 2. Pulmonary hemorrhage 3. anti-GBM ab
The presence of what are diagnostic for Anti-GBM disease?
anti-GBM ab
What two GN etiologies are classic for rapid progressive GN?
- Anti-GBM disease 2. Pauci-immune GN
T or F: Lupus nephritis presents on a range of injuries (classes I - VI)?
TRUE
ABN UA +/- increased serum creatine w/ + Anti-ds DNA Abs is diagnostic for what?
Lupus nephritis
