Glossary Flashcards
(25 cards)
Define drug target
Specific molecule to which drug binds to produce effect (usually protein)
Rs, ion channels, enzymes, transporters, TFs, adhesion molecules, structural elements, D/RNA
Define bilogics
Larger pharmaceutical molecules produced in a living system
Proteomics
Cell function studied by measuring protein expression, activity + interactions
Define taget validation
Process by which predicted target is verified
Define target exploitation
Process by which validated target is assessed
Define assay
Test system for measuring biological activity of target
R/Enz/functional activity
Define screen
Experimental system for evaluating the activity of test compounds
inhibition at R/Enz, functional modulation
Orphan receptors
Genetically identified receptors with no known ligand
Reporter gene
Labelled gene attached to regulatory sequence of another gene of interest
Knockout
Gene expression prevented
Knock in
cDNA coding for particular protein inserted into genome
Conditional knock out
Time or tissue specific
CRISPR
Clustered regulatory interspaced short palindromic repeats- prokaryote immune system component used to edit mammalian genes
Bio pharmaceuticals
Biologics
Azoles
antifungal- inhibit ergosterol synthesis
Polyenes
antifungal- bind resident ergosterol (faster)
Echinocandins
Inhibit CW synthesis- only new drug class in 10 years
Agonist
Molecule which interacts with receptor to produce response
Affinity
Capacity to bind
Efficacy
Capacity to excite
Spare receptors
Maximal response with less than maximal occupancy (property of agonist AND tissue)
Partial agonist
Sub maximal response with full occupancy/ low efficacy activity despite high affinity-
have affinity to inactive as well as active
Constitutively active receptors
Active w/o ligand bound
Inverse agonists
Reduce levels of constitutive activation
