Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CDCES Exam > GLP-1 & GIP Receptor Agonists > Flashcards

GLP-1 & GIP Receptor Agonists Flashcards

1
Q

What is the main action of the
GLP-1 Receptor Agonist?

A

They are called incretin memetics and they:
increase insulin release with food
slow gastric emptying
promote satiety
suppress glucagon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are examples of GLP- RA?

A

exenatide (Byetta)
exenatide XR (Bydureon)
liraglutide (Victoza)
dulaglutide (Trulicity)
lixisenatide (Adlyxin)
semaglutide (Ozempic - injection) and (Rybelsus - oral tablet)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are side effects of GLP-1 RAs?

A

Nausea, vomiting, weight loss, injection site reaction. Signs of acute pancreatitis (severe abdominal pain and vomiting) need to be reported. Dose is increased monthly to achieve targets.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the black box warning for GLP-1 RAs?

A

Thyroid C cell tumor warning (avoid if history of medullary thyroid tumor).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which GLP-1 RAs significantly reduce the risk of cardiovascular death?

A

liraglutide (Victoza), dulaglutide (Trulicity) and semaglutide (Ozempic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What GLP -1 RA is approved for pediatrics from 10-17 years old?

A

exenatide XR (Bydureon) and liraglutide (Victoza)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How much can GLP-1 RAs lower A1C?

A

Lowers A1C by 0.5-1.6%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How much weight loss can result from GLP-1 RAs?

A

4-6% weight loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the dose range for exenatide (Byetta)?

A

5 and 10 mcg BID

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the dose range for exenatide XR (Bydureon)?

A

2 mg once/week

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the dose range for liraglutide (Victoza)?

A

0.6, 1.2, and 1.8 mg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the dose range for dulaglutide (Trulicity)?

A

0.75, 1.5, 3, and 4.5 mg once/week as a pen injector

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the dose range for lixisenatide (Adlyxin)?

A

10 mcg once/day for 14 days
20 mcg/day starting on day 15

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the dose range for semaglutide (Ozempic)?

A

0.25, 0.5, 1, and 2 mg once/week per pen injector

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the dose range for Rybelsus?

A

3, 7, 14 mg daily in the morning. Must be taken on an empty stomach with no more than 4 ounces of water.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is a dual incretion agonist?

A

Tirzepatide (Mounjaro) which combines the GLP-1 RA and GIP incretin

17
Q

What is the dose range for trizepatide?

A

2.5, 5, 7.5, 10, 12.5, and 15 mg once/week in a prefilled single dose pen. The dose is increased monthly to reach targets.

18
Q

What are side effects of trizepatide?

A

Nausea, diarrhea, injection site reactions. Avoid if a family history of medullary thyroid tumor and report signs of pancreatitis.

19
Q

How much does trizepatide lower A1C?

A

1.8-2.4%

20
Q

How much weight can be lost on trizepatide?

A

7-13% weight loss at max dose

CDCES Exam (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions