Glycogen scheme and enzymes

Question 1

Glucose – > G-6-P? in glycogen synthesis

Answer 1

Hexokinase

Question 2

Glucose-6P –> Glucose-1-P? in glycogen synthesis

Answer 2

Phosphoglucomutase

Question 3

Glucose-1-P –> UDP glucose? in glycogen synthesis

Answer 3

UDP-glucose phosphorylase

Question 4

UDP glucose –> Glycogen (n)?

Answer 4

Glycogen synthase

Question 5

what enzyme is rate limiting in glycogen synthesis?

Answer 5

glycogen synthase

Question 6

glycogen (n) –> glycogen (n+1)?

Answer 6

branching enzyme

Question 7

glycogen (n+1) –> limit dextrin? glycogenolysis

Answer 7

glycogen phosphorylase

Question 8

what does glycogen phosphorylase?

Answer 8

liberates glucose-1-P residues off BRANCHED glycogen until 4 glucose units remain on a branch (limit dextrin)

Question 9

Limit dextrin –> 3 glucoses off the branch merged to linear glycogen + 1 glucose left on 1,6.

Answer 9

debranching enzyme (4-alpha-D-glucanotransferase)

Question 10

glucose-1-P from 1,6 bond liberation?

Answer 10

debranching enzyme (alpha 1,6 glucosidase)

Question 11

once 1,6 bond is debranched and linear glycogen left, what happens?

Answer 11

glycogen phosphorylase again liberates alpha 1,4 bonds –> liberated glucose 1-P

Question 12

liberated glucose-1-P –> glucose-6-P? enzyme

Answer 12

phosphoglucomutase

Question 13

what does glucose-6-P?

Answer 13

arba naudojama glikolizei (raumenyse) arba virsta i gliukoze (kepenyse) kad palaikyti glikemija

Question 14

What does hexokinase?

Answer 14

Glucose – > G-6-P

Question 15

what does Phosphoglucomutase?

Answer 15

G6P –> G1P ir atvirksciai

Question 16

what does UDP-glucose pyrophosphatase?

Answer 16

Glucose-1-P –> UDP glucose

Question 17

what does Glycogen synthase?

Answer 17

UDP glucose –> Glycogen (n)

Question 18

what does branching enzyme?

Answer 18

glycogen (n) –> glycogen (n+1)

Question 19

what does glycogen phosphorylase?

Answer 19

glycogen (n+1) –> limit dextrin

liberates glucose-1-P residues off BRANCHED glycogen until 4 glucose units remain on a branch (limit dextrin)

Question 20

what does debranching enzyme (4-alpha-D-glucanotransferase)?

Answer 20

Limit dextrin –> 3 glucoses off the branch merged to linear glycogen + 1 glucose left on 1,6

Question 21

what does debranching enzyme (alpha 1,6 glucosidase)?

Answer 21

glucose-1P from 1,6 bond liberation

Question 22

what does glycogen phosphorylase once 1,6 bond is debranched and linear glycogen left?

Answer 22

glycogen phosphorylase again liberates alpha 1,4 bonds –> liberated glucose 1-P

Question 23

what does phosphoglucomutase in glycogenolysis?

Answer 23

liberated glucose-1-P –> glucose-6-P