Glycolysis Flashcards Preview

Biochem > Glycolysis > Flashcards

Flashcards in Glycolysis Deck (10):

First step in Glycolysis

Glucose -> Glucose-6-phosphate

Enzyme: hexokinase (transferase)

-reaction is metabollically irreversible

-the product of the reaction allosterically inhibits hexokinase I, II, and III. This is an example of feedback inhibition

-reaction requires Mg2+, as a cofactor for ATP

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Second Step in Glycolysis

Enzyme: Glucose-6-phosphate isomerase (isomerase)

-subject to regulation through concentration Near Equilibrium reaction

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Third Step in Glycolysis

Enzyme: phosphofructokinase-1 (PFK-1)

-metabollically irreversible

-first commited step of glycosis since other substrates may enter glycolysis in a way that by-passes reactions one and two. Subject to intense regulation as a result

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4th step in glycolysis

Enzyme: 1,6-bisphosphate aldolase

-Near Equilibrium reaction

-produces glyceraldehyde and dihydroxyacetone phosphate (metabollic deadend)

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5th step in Glycolysis

Enzyme: triose phosphate isomerase (isomerase)

-near equilibrium reaction that is driven by the principle of mass action


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6th step in glycolysis

Enzyme: Glyceraldehyde-3-phosphate dehyrogenase (oxidoreductase)

NAD+ electron acceptor

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7th step in glycolysis

Enzyme:Phosphoglycerate kinase


-near equilibrium substrate-level phosphorylation

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8th step of glycolysis

Enzyme: Phosphoglycerate Mutase (Isomerase)

-near equilibrium reaction

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9th step of glycolysis

Enzyme: Enolase

-Magnesium is required to facilitate the forward reaction. Mg2+ stabilizes the terminal carboxylate group and catalyzes the dehydration reaction

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10th Step of Glycolysis

-substrate level phosphorylation

-reaction is metabollically irreversible

-Pyruvate Kinase (transferase)

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