Glycolysis

Question 1

When oxygen is in short supply NADH is reoxidize by reducing pyruvate to lactate. This permits glycolysis to continue. True or false?

Answer 1

True

Question 2

Glycolysis can occur under anaerobic condition. True or false?

Answer 2

True

Question 3

All of the enzymes of glycolysis are located in which part of the cell

Answer 3

cytosol

Question 4

What enzyme catalyze the phosphorylation of glucose to G6P?

Answer 4

hexokinase or glucokinase

Question 5

In the first reaction of glycolysis where glucose is phosphorylated,What is the phosphate donor?

Answer 5

ATP

Question 6

Is the phosphorylation of glucose to G6P reversible?

Answer 6

No

Question 7

What inhibits hexokinase

Answer 7

It is inhibited allosterically by its product G6P

Question 8

What controls the transport of glucose for glycolysis in the liver and for lipogenesis in any position?

Answer 8

Regulated by insulin

Question 9

This isoenzyme has a high affinity and low Km for glucose

Answer 9

Hexokinase

Question 10

Acts at a Constant rate to provide G6P to meet The livers needs

Answer 10

Hexokinase

Question 11

Isoenzyme of hexokinase present only in liver cells

Answer 11

Glucokinase

Question 12

This isoenzyme has a Km very much higher than normal intracellular concentration of glucose

Answer 12

glucokinase

Question 13

Functions to remove glucose from the hepatic portal blood following a meal

Answer 13

glucokinase

Question 14

detects high concentrations of glucose in the portal blood

Answer 14

Google kindness

Question 15

Is an important compound at the junction of several metabolic pathways

Answer 15

G6P

Question 16

G6Pis an important compound of several metabolic pathways such as

Answer 16

Glycolysis, gluconeogenesis, pentose phosphate pathway, glycogenesis, and glycogenolysis

Question 17

G6P is converted to F6P by what enzyme

Answer 17

Phosphohexose isomerase

Question 18

Phosphohexose isomerase is followed by

Answer 18

Aldose-ketose isomerization

Question 19

What is the net ATP per mol of glucose generated in glycolysis

Answer 19

Seven

Question 20

What are the three stages of glycolysis

Answer 20

Investment, splitting or cleavage,

Question 21

True or false: glycolysis in erythrocytes always terminates in lactate

Answer 21

True

Question 22

What tissues normally drive much of their energy from glycolysis and produce lactate

Answer 22

Brain, gastrointestinal tract, renal medulla, retina, skin

Question 23

Lactate production is increased during what conditions

Answer 23

Septic shock, cancer

Question 24

What three steps in glycolysis is regulated

Answer 24

Steps catalyzed by: hexokinase, phosphofructokinase, and pyruvate kinase

Question 25

This enzyme is significantly inhibited at normal concentrations of intracellular ATP

Answer 25

Phosphofructokinase

Question 26

Inhibition of phosphofructokinase can be rapidly relieved by

Answer 26

5 AMP

Question 27

Propose enters glycolysis by phosphorylation to

Answer 27

Fructose1 phosphate

Question 28

Erythrocytes what site of ATP formation in glycolysis may be bypassed

Answer 28

First site site or the reaction catalyzed by phosphoglycerate kinase

Question 29

True or false: the oxidation of pyruvate to acetyl-CoA is a reversible route from glycolysis to the citric acid cycle

Answer 29

True

Question 30

This complex is analogous to the alpha ketoglutarate dehydrogenase complex of the citric acid cycle

Answer 30

Pyruvate dehydrogenase complex

Question 31

What vitamin deficiency causes glucose metabolism to be impaired and significant lactic and pyruvic acidosis

Answer 31

Thiamin or vitamin B1

Question 32

What inhibits pyruvate is dehydrogenase

Answer 32

Pyruvate dehydrogenase is inhibited by its products acetyl-CoA and NADH

Question 33

It is regulated by phosphorylation of three serine residues on the pyruvate dehydrogenase component of the multi enzyme complex

Answer 33

Pyruvate dehydrogenase

Question 34

These two processes are inhibited when there is adequate ATP

Answer 34

Pyruvate dehydrogenase and therefore glycolysis