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Biochemistry > Glycolysis > Flashcards

Glycolysis Flashcards

1
Q

When oxygen is in short supply NADH is reoxidize by reducing pyruvate to lactate. This permits glycolysis to continue. True or false?

A

True

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2
Q

Glycolysis can occur under anaerobic condition. True or false?

A

True

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3
Q

All of the enzymes of glycolysis are located in which part of the cell

A

cytosol

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4
Q

What enzyme catalyze the phosphorylation of glucose to G6P?

A

hexokinase or glucokinase

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5
Q

In the first reaction of glycolysis where glucose is phosphorylated,What is the phosphate donor?

A

ATP

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6
Q

Is the phosphorylation of glucose to G6P reversible?

A

No

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7
Q

What inhibits hexokinase

A

It is inhibited allosterically by its product G6P

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8
Q

What controls the transport of glucose for glycolysis in the liver and for lipogenesis in any position?

A

Regulated by insulin

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9
Q

This isoenzyme has a high affinity and low Km for glucose

A

Hexokinase

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10
Q

Acts at a Constant rate to provide G6P to meet The livers needs

A

Hexokinase

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11
Q

Isoenzyme of hexokinase present only in liver cells

A

Glucokinase

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12
Q

This isoenzyme has a Km very much higher than normal intracellular concentration of glucose

A

glucokinase

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13
Q

Functions to remove glucose from the hepatic portal blood following a meal

A

glucokinase

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14
Q

detects high concentrations of glucose in the portal blood

A

Google kindness

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15
Q

Is an important compound at the junction of several metabolic pathways

A

G6P

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16
Q

G6Pis an important compound of several metabolic pathways such as

A

Glycolysis, gluconeogenesis, pentose phosphate pathway, glycogenesis, and glycogenolysis

17
Q

G6P is converted to F6P by what enzyme

A

Phosphohexose isomerase

18
Q

Phosphohexose isomerase is followed by

A

Aldose-ketose isomerization

19
Q

What is the net ATP per mol of glucose generated in glycolysis

A

Seven

20
Q

What are the three stages of glycolysis

A

Investment, splitting or cleavage,

21
Q

True or false: glycolysis in erythrocytes always terminates in lactate

A

True

22
Q

What tissues normally drive much of their energy from glycolysis and produce lactate

A

Brain, gastrointestinal tract, renal medulla, retina, skin

23
Q

Lactate production is increased during what conditions

A

Septic shock, cancer

24
Q

What three steps in glycolysis is regulated

A

Steps catalyzed by: hexokinase, phosphofructokinase, and pyruvate kinase

25
Q

This enzyme is significantly inhibited at normal concentrations of intracellular ATP

A

Phosphofructokinase

26
Q

Inhibition of phosphofructokinase can be rapidly relieved by

A

5 AMP

27
Q

Propose enters glycolysis by phosphorylation to

A

Fructose1 phosphate

28
Q

Erythrocytes what site of ATP formation in glycolysis may be bypassed

A

First site site or the reaction catalyzed by phosphoglycerate kinase

29
Q

True or false: the oxidation of pyruvate to acetyl-CoA is a reversible route from glycolysis to the citric acid cycle

A

True

30
Q

This complex is analogous to the alpha ketoglutarate dehydrogenase complex of the citric acid cycle

A

Pyruvate dehydrogenase complex

31
Q

What vitamin deficiency causes glucose metabolism to be impaired and significant lactic and pyruvic acidosis

A

Thiamin or vitamin B1

32
Q

What inhibits pyruvate is dehydrogenase

A

Pyruvate dehydrogenase is inhibited by its products acetyl-CoA and NADH

33
Q

It is regulated by phosphorylation of three serine residues on the pyruvate dehydrogenase component of the multi enzyme complex

A

Pyruvate dehydrogenase

34
Q

These two processes are inhibited when there is adequate ATP

A

Pyruvate dehydrogenase and therefore glycolysis

Biochemistry (5 decks)

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