Glycolysis/Krebs Flashcards

1
Q

GLYCOLYSIS

What is glucose converted into?

A

Glucose-6-phosphate

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2
Q

GLYCOLYSIS

What is glucose-6-phosphate converted into?

A

Fructose-6-phosphate

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3
Q

GLYCOLYSIS

What is fructose-6-phosphate converted into?

A

Fructose-1,6-biphosphate

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4
Q

GLYCOLYSIS

What is fructose-1,6-biphosphate converted into?

A

Dihydroxyacetonephosphate -> 3-phosphoglyceraldehyde (x2)

3-phosphoglyceraldehyde (x2)

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5
Q

GLYCOLYSIS

What is 3-phosphoglyceraldehyde converted into?

A

1,3-biphosphoglyerate

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6
Q

GLYCOLYSIS

What is 1,3-biphosphoglycerate converted into?

A

3-phosphoglycerate

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7
Q

GLYCOLYSIS

What is 3-phosphoglycerate converted into?

A

2-phosphoglycerate

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8
Q

GLYCOLYSIS

What is 2-phosphoglycerate converted into?

A

Phosphoenolpyruvate

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9
Q

GLYCOLYSIS

What is phosphoenolpyruvate converted into?

A

Pyruvate

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10
Q

What is pyruvate used in?

A

Converted into lactate

Substrate for Kreb’s cycle

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11
Q

GLYCOLYSIS

What enzyme catalyses the conversion of glucose to glucose-6-phosphate?

A

Hexokinase

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12
Q

GLYCOLYSIS

What enzyme catalyses the conversion of glucose-6-phosphate to fructose-6-phosphate?

A

Phosphohexose isomerase

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13
Q

GLYCOLYSIS

What enzyme catalyses the conversion of fructose-6-phosphate to fructose-1,6-biphosphate?

A

Phosphofructokinase-1

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14
Q

GLYCOLYSIS

What enzyme catalyses the conversion of fructose-1,6-biphosphate to 3-phosphoglyceraldehyde?

A

Fructose biphosphate aldolase

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15
Q

GLYCOLYSIS

What enzyme catalyses the conversion of dihydroxyacetone phosphate to 3-phosphoglyceraldehyde?

A

Triose phosphate isomerase

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16
Q

GLYCOLYSIS

What enzyme catalyses the conversion of 3-phosphoglyceraldehyde to 1,3-biphosphoglycerate?

A

Glyceraldehyde-3-phophate dehydrogenase

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17
Q

GLYCOLYSIS

What enzyme catalyses the conversion of 1,3-biphosphoglycerate to 3-phosphoglycerate?

A

Phosphoglycerate kinase

18
Q

GLYCOLYSIS

What enzyme catalyses the conversion of 3-phosphoglycerate to 2-phosphoglycerate?

A

Phosphoglycerate mutase

19
Q

GLYCOLYSIS

What enzyme catalyses the conversion of 2-phosphoglycerate to phosphoenolpyruvate?

A

Emolase

20
Q

GLYCOLYSIS

What enzyme catalyses the conversion of phosphoenolpyruvate to pyruvate?

A

Pyruvate kinase

21
Q

KREBS CYCLE

What is citrate converted into?

A

Isocitrate

22
Q

KREBS CYCLE

What is isocitrate converted into?

A

alpha ketoglutarate

23
Q

KREBS CYCLE

What is alpha ketoglutarate converted into?

A

Succinyl coenzyme A

24
Q

KREBS CYCLE

What is succinyl coenzyme A converted into?

A

Succinate

25
Q

KREBS CYCLE

What is succinate converted into?

A

Fumarate

26
Q

KREBS CYCLE

What is fumarate converted into?

A

Malate

27
Q

KREBS CYCLE

What is malate converted into?

A

Oxaloacetate

28
Q

KREBS CYCLE

What is oxaloacetate converted into?

A

Citrate

29
Q

KREBS CYCLE

What enzyme catalyses the conversion of citrate to isocitrate?

A

Aconitase

30
Q

KREBS CYCLE

What enzyme catalyses the conversion of isocitrate to alpha ketoglutarate?

A

Isocitrate dehydrogenase

31
Q

KREBS CYCLE

What enzyme catalyses the conversion of alpha ketoglutarate to succinyl coenzyme A?

A

alpha ketoglutarate dehydrogenase

32
Q

KREBS CYCLE

What enzyme catalyses the conversion of succinyl coenzyme A to succinate?

A

Succinyl coenzyme A synthetase

33
Q

KREBS CYCLE

What enzyme catalyses the conversion of succinate to fumarate?

A

Succinate dehydrogenase

34
Q

KREBS CYCLE

What enzyme catalyses the conversion of fumarate to malate?

A

Fumarate hydratase

35
Q

KREBS CYCLE

What enzyme catalyses the conversion of malate to oxaloacetate?

A

Malate dehydrogenase

36
Q

KREBS CYCLE

What enzyme catalyses the conversion of oxaloacetate to citrate?

A

Citrate synthase

37
Q

What is the relationship between glycolysis and the krebs cycle?

A

Pyruvate -> Acetyl CoA + CO2

Acetyl CoA activates the conversion of oxaloacetate to citrate

38
Q

Which reactions in glycolysis involve ATP hydrolysis?

A

Glucose -> Glucose-6-phosphate

Fructose-6-phosphate -> Fructose-1,6-bisphosphate

39
Q

What steps of glycolysis produce ATP?

A

1,3 bisphosphoglycerate -> 3 phosphoglycerate

phosphoenolpyruvate - > pyruvate

40
Q

What is the net gain from glycolysis per molecule of glucose?

A

2 NADH

2 ATP

41
Q

What is the rate limiting enzyme of the Krebs cycle?

A

Isocitrate dehydrogenase

42
Q

What is the net output of Krebs

A

2 ATP

6 NADH