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Flashcards in GNRs and Sepsis Deck (25)
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1

clinical signs of _____ included:

Fever > 38 or < 36
Leukocytosis or leukopenia or > 10% band cells
elevated heart rate or elevated respiratory rate

- systemic inflammatory response syndrome (SIRS)

2

SIRS + infection =

- sepsis

3

SIRS + low BP that is correctable by administration of fluids is

- severe sepsis

4

SIRS + persistent hypotension that needs drugs to increase vascular tone is

- septic shock

5

SIRS + persistent hypotension leading to:
- clotting disorders
- renal, hepatic or cardiac failure
- cognitive impairment
- accumulation of metabolic products

- multiorgan dysfunction syndrome

6

what organism causes most sepsis

- bacteria

7

microbial triggers of SIRS

- lipid (part of LPS in gram negatives)
- lipotechoic acid (gram positives) and peptidoglycan
- bacterial toxins

8

most likely mediator of SIRS in sepsis

- neutrophil

9

innate immune system recognizes these cells

these factors are recognized by

- PAMPs (pathogen-associated)
- DAMPs (host factors)

- pattern recognition receptors

10

gram negatives associated with sepsis in hospital settings

- E. coli
- P. aeruginosa
- A. Baumannii
- K. pneumoniae

11

P. aeruginosa found in

- soil and water

12

P. aeruginosa produces ____ which form

- pyoverdin and pyocyanin pigments
- form distinctive blue-green colonies

13

P. aeruginosa odor with infected wounds

- fruity, sweet odor

14

P. aeruginosa produce ___ in CF lungs which gives rise to

- polysaccharide alginate
- gives rise to mucoid colonies

15

P. aeruginosa have ______ defects with render the organisms sensitive to ________

- LPS defects
- sensitive to complement

16

risk factors for P. aeruginosa bloodstream infection

- immunocompromised (neutropenia, diabetes, immunodeficiency)
- burns
- indwelling medical devices

17

what is important in the biofilm for antibiotics and host immune response resistance

- extracellular polysaccharide production

18

P. aeruginosa antibiotics resistance of concern

- aminoglycosides
- cephalosporins
- fluoroquinolones
- carbapenems

19

A. baumannii found

- soil and water

20

A. baumannii shape

- coccobacilli or cocci

21

K. pneumoniae found

- colonizers of GI tract

22

K. pneumoniae notorious collector of

- drug resistance plasmids

23

K. pneumoniae structures

- composed of large polysaccharide capsule

24

part of K. pneumoniae that makes it resistance to antibiotics

- Klebsiella pneumoniae carbapenemase

25

LPS of gram negatives is part of what membrane

- part of the outer membrane