goljan

Question 1

TYPE II HSR reactions

Answer 1

complement dependent – complement independent

Question 2

complement dependent reactions

Answer 2

cell lysis :IgM (MAC) + IgG (C5a) —

phagocytosis : IgG + C3b

Question 3

complement independent reaction

Answer 3

ADCC- IgG + IgE —

IgG autoantibodies against cell surface receptors

Question 4

what type of HSR is causes by thermophilic actinomycetes

Answer 4

farmers lung - type of hypersensitivity pneumonitis - moldy hay – example of ARTHRUS REACTION

Question 5

IL-12 fxn

Answer 5

secreted by macrophages — tells naïve CD4 Th cells to go to Th1 cells

Question 6

what activates macrophages ?

Answer 6

IFN-gamma

Question 7

what infection is big in bone marrow transplant

Answer 7

CMV

Question 8

what happens to host blood group in bone marrow transplant

Answer 8

host assumes donor ABO group

Question 9

allograft

Answer 9

same species-but different genetics

Question 10

xenograft

Answer 10

different species

Question 11

human organ transplant is which type of graft

Answer 11

allograft

Question 12

grafts between identical twins

Answer 12

syngeneic graft ( isograft )

Question 13

hyperacute rejection HSV and causes

Answer 13

type II HSV – ABO + HLA mismatch

Question 14

MC transplant rejection

Answer 14

acute

Question 15

is hyperacute reversible or irreversible

Answer 15

irreversible - have to replace organ!

Question 16

is acute rejection reversible or irreversible

Answer 16

reversible

Question 17

most successful transplant organ

Answer 17

cornea

Question 18

what is the key cell that causes acute transplant rejection

Answer 18

dendritic cells from donor organ that has MHC class I and II cells

Question 19

acute rejection contains which HSR

Answer 19

type 2 - anti HLA preformed antibodies —

type 4 - DTH and cytotoxicity

Question 20

MC infection solid organ transplant

Answer 20

candida > aspergillus

Question 21

MC infection bone marrow transplant

Answer 21

aspergillus > candida

Question 22

autoimmune disease is a loss of ?

Answer 22

self tolerance

Question 23

polyclonal B cell activators?

Answer 23

HIV, EBV, CMV — this creates AUTOANTIBODIES

Question 24

what viruses are implicated in autoimmune disease

Answer 24

EBV, CMV, HHV-6, coxsackievirus, measles

Question 25

autoimmune disease -- EBV

Answer 25

hep B, SLE, RA

Question 26

autoimmune disease -- CMV

Answer 26

system sclerosis

Question 27

MS - viruses

Answer 27

HHV6 + influenza A

Question 28

autoimmune disease -- measles

Answer 28

acute disseminated encephalomyelitis

Question 29

autoimmune disease -- coxsackievirus

Answer 29

B3 - myocarditis | B4 - type I DM

Question 30

two bacteria that cause GUILLAIN BARRE

Answer 30

mycoplasma pneumonia + campylobacter jejuni

Question 31

what non MHC gene is involved in CROHNs

Answer 31

NOD-2

Question 32

what non MHC gene is involved in type 1 DM + RA

Answer 32

PTPN-22

Question 33

mechanism of injury in SLE

Answer 33

1. type 2 HSR -- autoantibodies cause cytopenias | 2. type 3 HSR -- ICs ( DNA-anti DNA) cause systemic inflammation ( vascultis )

Question 34

cardio manifestations in SLE

Answer 34

fibrinous pericarditis (serositis) w or w/o effusion MC --- libman sacks endocarditis

Question 35

what heart valve is affected in SLE

Answer 35

mitral valve --- causes regurg

Question 36

MC respiratory finding in SLE

Answer 36

pleuritic chest pain ( pain on INSPIRATION ) w or w/o effusion --- SEROSITIS

Question 37

lymph findings in SLE

Answer 37

generalized PAINFUL LAD + splenomegaly

Question 38

MSK finding in SLE

Answer 38

arthralgia - MCP+PIP -- non deforming

Question 39

SKIN finding in SLE

Answer 39

malar rash on face

Question 40

RENAL finding in SLE

Answer 40

membranous in nephrotic --- DPGN in nephritic | MCCOD

Question 41

RESPIRATORY finding in SLE

Answer 41

pleuritic chest pain --- SEROSITIS

Question 42

CNS findings in SLE

Answer 42

headache, seizures, strokes

Question 43

what causes strokes in SLE

Answer 43

antiphospholipid syndrome causes vessel thrombosis

Question 44

pregnancy complication in SLE

Answer 44

1. heart block in newborns (IgG SS-A(RO)) crosses the placenta 2. spontaneous abortion

Question 45

drug induced SLE

Answer 45

procainamide + hydralazine

Question 46

clinical findings in drug induced SLE

Answer 46

pleuritis, fever, arthralgia

Question 47

what is seen on the hands in dermatomyositis?

Answer 47

purple papules on the knuckles and PIP+DIP joints

Question 48

what is seen on the face in dermatomyositis?

Answer 48

swelling and red discoloration under the eyes

Question 49

how is serum complement affected in SLE

Answer 49

decreased b/c of IC formation

Question 50

what is used to treat SYSTEMIC SCLEROSIS

Answer 50

penicillamine for skin fibrosis --- cyclophosphamide for interstitial fibrosis

Question 51

what cells are increased in SCLERODERMA

Answer 51

CD4 Th2 cells causes cytokine release which damages endothelial cells leading to VASCULITIS

Question 52

MC initial sign in SYSTEMIC SCLEROSIS

Answer 52

Raynaud's phenomenon

Question 53

skin findings in SYSTEMIC SCLEROSIS

Answer 53

narrowing of digits causes raynauds phenomenon, sclerodactyly, thickened skin, and edema of the hands --- mouth has a mouse like appearance

Question 54

respiratory findings in SYSTEMIC SCLEROSIS

Answer 54

PH, interstitial fibrosis leads to restrictive lung disease and eventually resp failure --- MCCOD

Question 55

what are the noninfectious inflammatory myopahties

Answer 55

DM + PM

Question 56

both DM + PM have increased risk for

Answer 56

lung and bladder cancer + non Hodgkin malignant lymphoma