GP Flashcards

1
Q

What are some DDX for CAD?

A

Syphilis
Hyperthyroidism
Anaemia
Septic emboli
Collagen vascular disease (Kawasaki disease, polyarteritis nodosa, SLE, Ehlers-Danlos syndrome)
Other arrythmias (A Flutter, other atrial tachy-arrhythmias)

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2
Q

General categories of medications to manage CAD?

A

Rate control (beta blockers, CCBs, digoxin), Rhythm control, Anticoagulation (Warfarin, NOAC)

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3
Q

Which medications for CAD rate control do you choose if it is needed urgently IV?

A

Metoprolol 5mg (1mg/min) IV at 5 minute intervals up to max 20mg
Esmolol 500microg/kg over 1 min
Verapamil 1mg/min up to 15mg

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4
Q

What are some differentials for a sore throat?

A
Necrotising fasciitis
Retropharyngeal abscess
Lemierres syndrome
Quinsy
Otitis media
Glomerulonephritis
Rheumatic fever
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5
Q

What is first line management for Croup?

A
Inhaled corticosteroids (Budesonide, dex or pred)
\+/- adrenalin 0.1% (1:1000, 1mg/kg) 4mL nebs Q30 mins
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6
Q

What is the six step asthma management plan?

A

Assess severity of asthma
Achieve best lung function
Avoid trigger factors
Maintain best lung function with optimal medication
Develop and individua`lised written action plan
Educate and review regularly

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7
Q

How do you make a clinical diagnosis of (acute) Sinusitis?

A

With 2+ of:

  • Congestion
  • Nasal discharge
  • Facial pain
  • Hypoxmia/anosmia
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8
Q

How do you make a clinical diagnosis of bacterial sinusitis?

A

Symptoms of rhinosinusitis lasting >1 week + any of:

  • High fever lasting >3 days
  • Purulent nasal discharge
  • Sinus tenderness or maxillary toothace (esp. unilateral)
  • Severe symptoms or worsening symptoms post-initial improvement
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9
Q

What are some complications of sinusitis?

A
Orbital cellulitis
Osteomyelitis
Abscess formation
Venous sinus thrombosis
Bacterial meningitis
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10
Q

What is first line for chronic sinusitis?

A

Prednisolone 25mg PO for 5-10/7

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11
Q

What is the BRAT diet?

A
Diet used for gastro if diarrhoea continues or worsesn over about 3 days:
B = Bananas
R = Rice
A = Apples
T = Toast
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12
Q

What are the clinical features of Hirschprung disorder?

A
Congenital
Constipation from infancy
Abdominal distension from infancy
Possible anorexia and vomiting
M:F ratio = 8:!
Narrow or normal rectum on exam
Dx confirmed by: full thickness biopsy showing absence of ganglion cells
Absent rectoanal reflex on anal manometry
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13
Q

What are the causes of acquired megacolon?

A
Chronic laxative abuse
Mild Hirschprung disorder
Chagas disease
Hypothyroidism/cretinism
Systemic sclerosis
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14
Q

How do you manage angiodysplasia?

A

Blood transfusion - if loss significant

Cautery/argon plasma coag therapy through endoscopy

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15
Q

Management of gastroenteritis?

A

Fluid therapy
Electrolyte replacement

Empirical antibiotics:

  • Cipro 500mg (child: 12.5mg/kg up to 500mg) orally once daily for 3/7 OR
  • Norflox 400mg (child: 10mg/kg up to 400mg) orally adily for 3/7

Giardia: metronidazole 2g for 3/7

Entamoeba histolytica: Paromomycin 500mg (child: 10mg/kg up to 500mg), orally 8 hrly for 7 days

Clostridium difficile: Metronodazole 400mg for 10/7

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16
Q

When is empirical antibiotic therapy indicated for gastroenteritis?

A

When bacterial infection suspected in patients with features suggesting severe disease:
high fever, tachycardia, leukocytosis, abdominal tenderness or severe abdo pain, high-volume diarrhoea with hypovolemia, blood in the stool

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17
Q

Why is antibiotic therapy not recommended in children with bloody diarrhoea without fever?

A

If caused by EHEC can lead to haemolytic uremic syndrome

18
Q

What are some red flags for GORD?

A
Anaemia
Dysphagia
Haematemesis and/or malaena
Vomiting
Weight loss
19
Q

Management for GORD?

A

Non pharmacological:

  • eating smaller meals
  • drinking f luids mostly between meals rather than with meals
  • avoiding lying down after eating
  • avoiding eating or drinking for 2-3 hrs before bedtime
  • avoid vigorous exercise before bedtime
  • elevate head of bed
  • stop smoking

Pharmacological:

  1. Antacid
  2. Alginate preparation 10-20mL PO PRN
  3. Mg hydroxide + Al hydroxide prep 10-20mL PO PRN
  4. H2 antagonist (ranitidine 150mg or famotidine 20mg PO BD)
  5. PPI (Esomeprazole/Omeprazole 20mg OR pantoprazole 40mg)
  6. Lap fundoplication
20
Q

How often should a patient to get fasting lipids tested?

A

<45 or <35 for ATSI with fasting lipids tested every 5 years

21
Q

What are the recommended treatment goals of dyslipidemia? (i.e. levels of lipids)

A

Total cholesterol <4.0 mmol/L
LDLC <2.5mmol/L
HDLC > 1.0 mmol/L
TG <1.5 mmol/L

22
Q

What the pharmacological management options for dyslipidemia?

A

Statin - e.g atorvastatin 10-80mg

Ezetimibe
Bile acid binding resins
Nicotinic acid
Fibrates

23
Q

What side effects are associated with nicotinic acid?

A

Flushing, gastric irritation, gout, impaired glucose tolerance

24
Q

What interactions occur associated with fibrates?

A

Fibrates + Statins = increased risk of myositis

25
What are the presenting clinical features of patient with Vitamin B12 deficiency?
Anaemic symptoms: weakness, fatigue, palpitations, SOB, pallor GIT symptoms: diarrhoea, consipation, loss ofbladder or bowel control Neurological symptoms: Depression, Irritability, Peripheral neuropathy, Mania, Psychosis, Memory loss, Ataxia Other: Tongue inflammation, Decreased taste, Poor growth and development, Easy bruising, bleeding, Bleeding gums
26
Other than other types of anaemia - what are some DDx of B12 deficiency?
``` Thiamine deficiency Alcohol intoxication Schizophrenia Depression Dementia DIabetes Leukemia ```
27
What is the acute management for Vitamin B12 deficiency?
Hydroxocobalmin 1mg IM, on alternate days for 2 weeks If severe anaemia/neurological symptoms: give supplementation ASAP
28
What is the maintenance therapy for Vitamin B12 deficiency?
Lifelong therapy - Hydroxocobalamin 1mg IM, once every 2-3 months OR - Cyanocobalamin 50-200microg orally (daily between meals) - +/- K supplementation
29
What is Wernicke's encephalitis classical triad?
Opthalmoplegia (mostly bilateral LR with lateral nystagmus) Ataxia Confusion
30
What is the management for Thiamine deficiency?
Thiamine 100mg PO daily (start with higher dose) - Administer thiamine before glucose for hypoglycemia as glucose can further deplete thiamine stores and precipitate Wernicke's encephalopathy + promote increase in dietary thiamine
31
What are red flags for iron deficiency anaemia?
in >65. it is colorectal cancer until proven otherwsie - do a DRE and colonoscopy
32
How do you diagnose Haemophilia? (lab)
Normal BT, PT, TT | Prolonged PTT
33
How do you diagnose ITP?
Diagnosis of exclusion: Low platelet count Bone marrow biopsy Bone marrow examination No blood abnormalities other than platelet count or no physical signs other than bleeding Exclude secondary causes: leukemia, vWD, antiphospholipid syndrome
34
How do you manage ITP?
MIld - careful observation Mod-severe - Corticosteroids, IV Ig, Anti-D Ig, immunosuppressive drugs Splenectomy - if unresponsive to steroid treatment
35
What is treatment for TTP?
Supportive + Plasmaphoresis + Transfusion contraindicate: fuels coagulopathy
36
What do these features indicate: malaise + pallor + bone pain?
ALL
37
What do these features indicate: malaise + pallor + oral problems?
AML
38
What do these features indicate: fatigue + fever + abdo fullness/splenomegaly?
CML
39
What do these features indicate: fatigue + weight loss + fever + lymphadenopathy?
CLL
40
How do you diagnose Hodgkin's lymphoma?
Lymph node biopsy with histological confirmation FBC CXR, CT/MRI Bone marrow biopsy, functional isotopic scanning