gram negative bacilli (enterobacterales) Flashcards

1
Q

enterobacterales characteristics (5)

A
  1. found in colon
  2. oxidase negative
  3. ferments glucose
  4. cell wall: somatic O antigen and flagellar H antigen
  5. macconkey agar: fermenting or non-fermenting
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2
Q

lactose fermenting enterobacterales (2)

A
  1. e. coli
  2. klebsiella
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3
Q

non-lactose fermenting enterobacterales (3)

A
  1. salmonella
  2. shigella
  3. proteus
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4
Q

escherichia coli virulent strains (4)

A
  1. EHEC (enterohaemorrhagic e coli)
  2. VTEC (verocytotoxin-producing e coli)
  3. STEC (shiga-like toxin e coli)
  4. ETEC (enterotoxic e coli)
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5
Q

escherichia coli clinical presentations (4)

A
  1. commonest cause of UTI
  2. neonatal septicaemia, meningitis (vertical transmission)
  3. diarrhoeal disease (by virulent strains)
  4. shiga-LIKE toxin is absorbed, spread through bloodstream–> Haemolytic Uraemic Syndrome–> renal failure/death
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6
Q

escherichia coli transmission

A

faecal-oral (normal gut flora)

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7
Q

escherichia coli treatment (3)

A
  1. ceftriaxone (not for ESBL strains)
  2. carbapenems
  3. ciprofloxacin

HYDRATION!!!!!

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8
Q

klebsiella clinical presentations (3)

A
  1. common cause of community & nosocomial UTI
  2. friedlander’s pneumonia (severe community acquired bronchopneumonia w abscess)
  3. nosocomial infections (mostly by ESBL strains)
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9
Q

klebsiella pneumonia transmission (2)

A
  1. droplets
  2. faecal-oral
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10
Q

klebsiella pneumonia treatment (3)

A
  1. ceftriaxone (not for ESBL strains)
  2. carbapenems
  3. ciprofloxacin

HYDRATION!!!!!

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11
Q

enteric/typhoidal salmonella (S. typhi, S. paratyphi) transmission

A

faecal-oral

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12
Q

enteric/typhoidal salmonella (S. typhi, S. paratyphi) clinical presentations (2)

A
  1. typhoid fever (rose spots, slowly rising fever)
  2. ulceration & perforations of peyer’s patches (due to infected bile from gallbladder)
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13
Q

enteric/typhoidal salmonella (S. typhi, S. paratyphi) treatment (2)

A
  1. ceftriaxone
  2. ciprofloxacin
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14
Q

non-typhoidal salmonella transmission

A

foodborne (poorly cooked poultry/eggs, animal faecal contamination)

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15
Q

non-typhoidal salmonella clinical presentations (2)

A
  1. gastroenteritis/food poisoning
  2. bacteremia (causes invasive infections)
  3. UTI
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16
Q

non-typhoidal salmonella treatment (2)

A
  1. ceftriaxone
  2. ciprofloxacin
17
Q

shigella transmission (2)

A
  1. faecal oral
  2. flies
18
Q

shigella clinical presentations (2)

A
  1. shigellosis (form of gastroenteritis, low ID50)
  2. bacterial dysentery due to SHIGA toxin–> bloody diarrhoea & HUS
19
Q

shigella treatment (2)

A
  1. ceftriaxone
  2. ciprofloxacin
20
Q

proteus character

A

swarming effect in waves on blood agar

21
Q

proteus clinical presentations (2)

A
  1. UTI
  2. renal stones (urease production–> hydrolyses urea in urine to form ammonia–> alkalinisation of urine–> calculi formation)
22
Q

proteus treatment (2)

A
  1. ceftriaxone
  2. ciprofloxacin
23
Q

enterobacterales treatment (2)

A
  1. ceftriaxone
  2. ciprofloxacin
    carbapenams for ESBL strains