Group carriers- L10 + 11 (M3+4)

Question 1

What is the carrier for C1 (methyl) ?

Answer 1

S-adenosylmethionine (SAM)
SAM -> S- adenosylhomocysteine -> homocysteine -> methionine ->

Question 2

What is the carrier for C2 (acetyl)?

Answer 2

Coenzyme A
Attaches to sulfur on thioester group

Question 3

Why does having a thioester group make a good carrier?

Answer 3

Thioester more unstable than ester group
Makes transfer of acetyl easier

Question 4

Examples of when CoA is used

Answer 4

Fatty acid biosynthesis
Link reaction (pyruvate -> acetyl CoA fed into kreb cycle)

Question 5

What is the carrier for C5?

Answer 5

Isopentenyl pyrophosphate

Question 6

What is C5 made from?

Answer 6

3x acetyl CoA molecules (C6)
mevalonate -> phosphomevalonate -> pyrophosphomevalonate -> isopentenyl pyrophosphate