Growth hormone related drugs

Question 1

Growth hormone agonists (2 drugs)

Answer 1

Somatropin

Mecasermin

Question 2

Somatropin - indications

Answer 2

Growth hormone deficiency in children (Turner, Prader-Willi, cystic fibrosis).
HIV: muscle waisting.

Question 3

Somatropin - contraindications

Answer 3

Malignancies, critically ill patients

Question 4

Somatropin - adverse effect in Turner syndrome

Answer 4

Otitis media

Question 5

Somatropin - MOA

Answer 5

Same as growth hormone: Direct stimulation of lipolysis. Insulin antagonist.
Indirect stimulation of insulin-like growth factor 1 (IGF-1): skeletal muscle growth, protein synthesis, cell proliferation.

Question 6

Mecasermin - MOA

Answer 6

Same as insulin-like growth factor 1 (IGF-1): skeletal muscle growth, protein synthesis, cell proliferation

Question 7

Mecasermin - indications

Answer 7

IGF-1 deficiency
GH receptor mutations
Antibodies to GH

Question 8

Mecasermin - adverse effects

Answer 8

Hypoglycemia

Question 9

Growth hormone inhibitors (3 drugs)

Answer 9

Ocreotide
Lanreotide acetate
Cabergoline

Question 10

All GH inhibitors can be used for?

Answer 10

Acromegaly

Question 11

Ocreotide - indications

Answer 11

Acromegaly
Hormone-secreting tumors (carcinoid, VIP-secreting) + treatment of associated diarrhea.
Acute bleeding from esophageal varices

Question 12

Ocreotide - adverse effects

Answer 12

Steatorrhea, gall stones.
Arrhythmias.
(Hyper) and hypoglycemia

Question 13

Ocreotide - interactions

Answer 13

Alter requirement of antidiabetes drugs

Question 14

Classification of Ocreotide, lanreotide acetate and cabergoline

Answer 14

Ocreotide - Somatostatin analogue
Lanreotide acetate - ocreotide analogue
Cabergoline - dopamine D2 agonist

Question 15

Growth hormone receptor antagonist (1 drug)

Answer 15

Pegvisomant

Question 16

Pegvisomant - indications

Answer 16

Acromegaly (esp pt resistant to somatostatin analogues)