gu Flashcards
(220 cards)
1
Q
What is the innervation of bladder relaxation?
A
- Autonomic sympathetic (noradrenergic)
- T10-L2 nuclei
- Urethral contraction (smooth muscle component but remember the main part of the sphincter is skeletal muscle)
- Inhibits detrusor contraction
2
Q
Spinal reflexes for bladder
A
- Reflex bladder contraction - sacral micturition centre
- Guarding reflex - onuf’s nucleus (rhabdosphincter - skeletal muscle so somatic)- the guarding reflex occurs to prevent voiding of the bladder caused by unexpected abdominal pressure.
- Receptive relaxation - sympathetic - the smooth muscles of the proximal part of the stomach relax and dilate when food enters the stomach. This receptive relaxation enables a large amount of food to amass in the stomach with a minimal rise in intragastric pressure.
3
Q
What is the function of the proximal convoluted tubule?
A
Reabsorption of:
- some water and Na+
- some other ions
- all glucose and amino acids
4
Q
What is the function of the distal convoluted tubule?
A
- Regulating acid-base balance
- By secreting H+ and absorbing HCO3-
- Also regulates Na+ level
5
Q
What is the structure of the collecting duct in the kidney?
A
Principal cells:
- Regulate Na+ reabsorption and K+ excretion
- Respond to aldosterone and ADH
Intercalated cells:
- Exchange H+ for HCO3-
6
Q
What is the structure of urothelium?
A
- Complex stratified epithelium
- Can stretch in 3 dimensions
- Layer of umbrella cells - make it urine proof
7
Q
What is the innervation of bladder contraction?
A
- Autonomic parasympathetic (cholinergic)
- S3-S5 nuclei
- Drive detrusor contraction
8
Q
What is the innervation of A-δ fibres (bladder stretch) and C fibres (bladder pain)?
A
- Sensory autonomic
- S2-S4 nuclei
9
Q
Functions of the prostate
A
- Produces testosterone and dihydrotestosterone (5x more potent)
- Produces PSA (prostate specific antigen)- liquefies semen
10
Q
Storage lower urinary tract symptoms (LUTS)
A
Occur when bladder should be storing urine -> need to pee
Frequency
Urgency
Nocturia
Incontinence
More common in females
11
Q
Voiding lower urinary tract symptoms (LUTS)
A
Occur when bladder outlets obstructed -> hard to pee
Poor Stream
Hesitancy
Incomplete emptying
Dribbling after finishing urination
More common in males
12
Q
What is Prehn’s sign?
A
- Used to determine the cause of testicular pain
- Performed by lifting the scrotum and assessing the consequent changes in pain
- Prehn’s sign positive = pain relief upon elevation
13
Q
What is the cremasteric reflex?
A
Stroke inner thigh, ipsilateral testicle should elevate
14
Q
What is an unsafe bladder?
A
One that puts the kidneys at risk - caused by prolonged high pressure
15
Q
What is erectile dysfunction?
A
- Persistent inability to attain amd maintain an erection sufficient to permit satisfactory sexual performance
- Commonly found in men over 40
- Up to 10% of men are affected
16
Q
Pathophysiology of erectile dysfunction
A
- Neurogenic - failure to initiate
- Arteriogenic - failure to fill (mc)
- Venogenic - failure to store
prolactin
17
Q
Innervation of the penis
A
- Sympathetic - T11 - L2
- Parasympathetic - S2-S4
18
Q
Aetiology of erectile dysfunction
A
- Atherosclerosis
- Diabetes
- Age
- Hypogonadism
- Trauma to pelvic plexus
- Iatrogenic - surgery that damages pelvic plexus, drugs
- Psychosomatic
19
Q
Treatment of erectile dysfunction
A
- Treat underlying cause
- oralphosphodiesterase type 5 inhibitor drugs- increase blood flow
- Psychosexual counselling if necessary
- Intracavernosal injection
- Vaccuum assisted device
- Implant
20
Q
Pathophysiology of acute kidney injury
A
Accumulation of usually excreted substances:
- K+ (arrhythmias)
- Urea (pruritis + uremic frost, confusion if severe)
- Fluid (pul + peripheral oedema)
- H+ (acidosis)
21
Q
Pre-renal AKI
A
Due to hypoperfusion of the kidneys, leading to decreased GFR
- Hypovolaemia
- Reduced cardiac output (cardiac failure, liver failure, sepsis, drugs)
- Drugs that reduce blood pressure (ACE-i, ARBs, NSAIDs, loop diuretics)
22
Q
Renal AKI
A
A consequence of structural damage to the kidney, eg: tubules, glomeruli, interstitium, bvs. May result from persistent pre-renal and post-renal causes, damaging renal cells
- Toxins and drugs (eg: antibiotics, contrast agent, chemo)
- Vascular causes (eg: vasculitis, thrombosis, etc)
- Glomerular, tubular (MC) or interstitial causes
23
Q
Post-renal AKI
A
Least common (10%) - due to acute obstruction of the flow of urine -> increased intratubular pressure and decreased GFR
- Renal stones
- Blocked catheter
- Enlarged prostate
- GU tract tumours
- Neurogenic bladder
24
Q
Diagnosis of AKI
A
- Establish cause (pre, intra, post) w KDIGO classification
- Check K+, H+, urea, creatining w U+E
- FBC + CRP check for infection
- Renal biopsy will confirm intrarenal cause, ultrasound for post renal
25
Treatment for AKI
- Treat complications
- Fluid rehydration with IV fluids for pre-renal AKI
- Stop nephrotoxic medications
- Relieve obstruction in post-renal AKI
- Last resort = Renal replacement therapy
26
What is acute kidney injury?
Abrupt decline in kidney function (hours-days) characterised by high serum creatinine + urea and low urine output
27
NICE criteria for acute kidney disease (any one)
- Rise in serum creatinine of > 25μmol/L within 48 hours
- 50% or greater rise in serum creatinine over 7 days
- A fall in urine output to less than 0.5ml/kg/hour for more than 6 consecutive hours
28
Risk factors for acute kidney injury
- 65+
- Comorbidities
- Cognitive impairment (less water intake)
- Hypovolaemia of any cause
- Oliguria
- Nephrotoxic drug use including contrast agents
29
Best way to establish cause of AKI
Urea:Creatinine
> 100:1 = Prerenal
< 40:1 = Renal
40-100:1 = Postrenal
30
When would haemodialysis be given for AKI
Acidosis (pH<7.1)
Fluid overload (oedema)
Uremia
K+ >6.5 /ECG change
31
Complications of AKI
- Hyperkalaemia (most important)
- Rhabdomyolysis
32
Risk factors for benign prostatic hyperplasia
- Age (50+)
- Men (obviously)
- Afrocarribean = high testosterone
33
Pathophysiology of benign prostatic hyperplasia
- Inner transitional zone of prostate (muscular, gland) proliferates
- Causes narrowing of the urethra
34
Presentation of benign prostatic hyperplasia
LUTS
35
What happens in benign prostatic hyperplasia if the urethra is totally occluded?
Anuria
- Retention
- Hydronephrosis
- UTI
- Stones
36
Diagnosis of benign prostatic hyperplasia
Digital rectal examination (DRE) - Smooth, enlarged
Prostate-specific antigen (PSA) - To rule out prostate cancer (but unreliable as it can be raised in both, but more in cancer)
37
Treatment for benign prostatic hyperplasia
- First line: Alpha blocker (tamsulosin)
- Second line: 5 alpha reductase inhibitor (finasteride) - decreases testosterone production and therefore prostate size
- Last resort, surgery - TURP - transurethral resection of the prostate (SE = retrograde ejaculation)
38
Pathophysiology of CKD
- Many nephrons damaged, increased burden on the remaining nephrons
- Compensatory RAAS but this increases transglomerular pressure -> shearing and loss of BM selective permeability -> proteinuria/haematuria
- Angiotensin 2 upregulates TGF-beta and plasminogen activator-inhibitor-1 -> mesangial scarring
39
Normal eGFR
120mL/min/1.73m2
40
When is metformin contraindicated?
When eGFR < 30
41
CKD G scores (eGFR)
G1. ≥ 90ml/min/1.73m2
G2. 60-90ml/min/1.73m2
G3a. 45-59ml/min/1.73m2
G3b. 30-44ml/min/1.73m2
G4. 15-29ml/min/1.73m2
G5. <15ml/min/1.73m2
42
Best clinical readings to quantify CKD
- eGFR
- Albumin:Creatinine (more sensitive measurement of proteinurea than PCR)
43
Aetiology of CKD
- T2DM
- Hypertension
- Glomerulonephritis
- PKD
- Nephrotoxic drugs
44
Risk factors for CKD (other than diseases)
- Older age
- Family history
- Smoking
45
Presentation of CKD
- Asymptomatic early on (lots of nephrons = reserve supply)
- Symptoms due to substance accumulation + renal damage (diabetic nephropathy)
- Pruritis, loss of appetite, nausea, oedema, muscle cramps, pallor
46
Complications of CKD
- Anaemia (Low EPO)
- Osteodystrophy (low vit D activation)
- Neuropathy and encephalopathy
- CVD and hypertension
- Haematuria and proteinuria
47
Diagnosis of CKD
- FBC for anaemia
- U+E for eGFR
- Early morning urine dipstick for haematuria and albumin:creatinine (>70mg/mmol = significant proteinuria)
- Ultrasound shows bilateral renal atrophy
48
Treatment for CKD
No cure so treat complications:
- Anaemia: Fe + EPO
- Osteodystrophy: Vit D supplements
- CVD: ACE-i and statins
- Oedema: diuretics
- Stop NSAIDs
- Stage 5 (end stage renal failure) -> RRT (dialysis)
- Ultimately if ESRF, cure is renal transplant
49
CKD A scores (albumin:creatinine)
A1. < 3mg/mmol
A2. 3-30mg/mmol
A3. >30mg/mmol
50
A patient has a score of A1 combined with G1 or G2. Can they be diagnosed with CKD?
No. They need at least an eGFR of <60 or proteinuria
51
What type of cancer is bladder cancer?
- Transitional cell carcinoma of bladder (mc, and mc subtype is transitional urothelium)
- If patient has schistosomiasis, they are more likely to have squamous cell carcinoma
52
Risk factors for bladder cancer
- Smoking
- Age 55+
- Males
- Occupational exposure to aromatic amines, eg: painter, hairdresser (dyes), mechanic working with tyres (rubber)
- Chemo/radiotherapy (cyclophosphamide)
53
Presentation of bladder cancer
- Painless visible haematuria
- LUTS
- Recurrent UTIs
54
Diagnosis of bladder cancer
Gold standard: flexible cystoscopy + upper tract imaging
55
NICE 2 week wait referral criteria for bladder cancer
Age 45 or above with:
- Unexplained visible haematuria
- or visible haematuria that persists after UTI treatment
Age 60 or above with:
- Unexplained non-visible haematuria
- and either: dysuria or raised white cell count
56
Treatment for bladder cancer
T1: Transurethral resection of bladder tumour
T2-3: Cystoprostatectomy in men, anterior extentoration in women
T4: Palliative or chemo/radiotherapy
Intravesical therapy: mitomycin and BCG to reduce recurrence
57
Transitional cell carcinoma of the upper tract
- Less common
- Same risk factors as bladder cancer
- Haematuria, loin pain, “clot colic”
- Managed by nephroureterectomy
58
Risk factors for renal cell carcinoma
- >40
- Smoking
- Obesity
- Male
- Hypertension
- Haemodialysis (15% chance)
- Von-Hippel Lindau syndrome (also tuberous sclerosis, Burt Hogge Dube and hereditary papillary RCC)
59
What is Von-Hippel Lindau syndrome?
- Autosomal dominant loss of tumour suppressor gene
- RCC (50%) bilaterally
- Renal + pancreas cysts
- Cerebellum cancers, pheochromocytomas
60
Presentation of renal cell carcinoma
- Often asymptomatic and found incidentally, 25% metastasised cases at presentation
- Triad: loin pain, haematuria, abdo mass
- May have left sided varicocele- rare block of test. vein
-malaise, anorexia, weight loss, pyrexia
- Anaemia (low EPO)
-can secrete renin- hypertension
61
Diagnosis of renal cell carcinoma
- First line: Ultrasound
- Gold standard: CT chest/abdo/pelvis
62
Renal cell carcinoma metastases
- Spreads to the tissues around the kidney, within Gerota's fascia
- Often spreads to the renal vein, then IVC
- "Cannonball metastases" in the lungs are a classic feature of renal cell carcinoma
63
Staging of renal cell carcinoma
1 - confined to renal capsule
2- through capsule, confined to Gerota's fascia
3- renal vein or vena cava involvement and/ or regional node involvement
4- direct organ invasion or distant metastases
64
Treatment for renal cell carcinoma
- Sometimes watch and wait
- Radiofrequency ablation or cryotherapy (only if tumour is <4cm)
- Gold standard: Partial nephrectomy- if both kidneys affected
- Radical (full) nephrectomy (most common)
65
What type of cancer is renal cell carcinoma?
PCT epithelial carcinoma
66
NICE two week wait referral criteria for renal cancer
45 or over with:
- Unexplained visible haematuria without UTI
- or visible haematuria that persists after treated UTI
67
What is a Wilms tumour?
- Renal mesenchymal stem cell tumour found via us/ct and treated with chemo/radio
- Seen in children (<3 years)
- Much rarer. 90% survival
- Aka: nephroblastoma
68
What type of cancer is prostate cancer?
Adenocarcinoma of outer peripheral prostate
69
Risk factors for prostate cancer
- Genetic: BRCA1, BRCA2, HOXB13
- Increased age
- Afrocaribbean ethnicity
70
Presentation of prostate cancer
- LUTS
- Systemic cancer symptoms (weight, loss, fatigue, night pain)
- Bone pain
71
Prostate cancer metastases
- Typically to bone (thick sclerotic lesions)
- Typically lumbar back pain
- Also liver, lung, brain
72
Diagnosis of prostate cancer
- DRE + PSA (3-10ng/ml= benign hyperplasia or cancer, >10 usually cancer) in community
- Gold standard: Transrectal ultrasound, multiparametric mri
- transperineal ultrasound guided Biopsy
all gives Gleason score - higher = worse
73
Treatment of metastatic prostate cancer
- Hormone therapy
- Bilateral orchidectomy (best)
- GNRH receptor agonist eg: goserelin
- Survielance in early disease
- External beam radiotherapy directed at prostate
- Barchytherapy
- Radiotherapy done via seeds inside prostate
- Bicalutamide
- Surgery to remove prostate
74
Treatment of localised prostate cancer
- Radical prostatectomy
- Radiotherapy - external beam, bachytherapy
- Watchful waiting
75
What type of cancer is testicular cancer?
Germ cell (90%+) or non germ-cell (<10%) tumour
Germ = seminoma (mc) or teratoma
Non germ = sertoli, leydig, sarcoma
76
Risk factors for testicular cancer
- Most common cancer in young men 20-45 (more common in caucasians)
- Cryptorchidism (undescended testes)
- HIV
- Previous testicular cancer
- Infertility
- Family history
77
Presentation of testicular cancer
- Painless, hard, irregular lump in testicle
- Does not transilluminate
- May show lung metastasis signs, eg: cough -> consider chest x-ray
- Gynaecomastia (breast enlargement) if it is a Leydig cell tumour (rare)
78
Diagnosis of testicular cancer
- Examination including lymph nodes, testes and scars from previous orchidopexy
- Urgent (Doppler) ultrasound of testes (90% diagnostic)
- Bloods for tumour markers
- CXR if resp symptoms
- Staging: CT chest/abdo/pelvis
79
Tumour markers for testicular cancer
- beta hCG - raised in seminomas
- AFP - raised in teratomas
- LDH raised non-specifically
80
Royal Marsden staging system for testicular cancer
1. Isolated to testicle
2. Spread to retroperitoneal lymph nodes
3. Spread to lymph nodes above diaphragm
4. Metastasised to other organs (mc: lymphatics, lungs, liver, brain)
81
Treatment of testicular cancer
- Urgent inguinal orchidectomy (+ offer sperm banking)
- Adjuvant chemotherapy
Or radiotherapy
82
Classification of incontinence
- Stress incontinence (sphincter weakness)
- Urge incontinence (detrusor or bladder overactivity)
- Mixed incontinence
- Overflow incontinence
- Spastic paralysis (neurological UMN lesion)
83
Suprapontine incontinence
- Mid brain functioning but not controlled by cortex (will present with neuro problems like dementia or cerebral palsy)
- Reflex bladder and bowel - involuntary urination and defaecation
- Coordinated sphincter
Complete emptying
84
Spastic SCI incontinence- spinal cord injury
- Conus functioning but not controlled by brain (sphincter isn’t being told to relax by pons)
- Reflex bladder and bowel - involuntary urination and defaecation
- Dyssynergic sphincter
Incomplete emptying
85
Flaccid SCI incontinence
- Conus destroyed or non-functional
- Areflexic bladder and bowel - fill until they overflow
- Non-functional sphincter
86
Management of stress incontinence
Women:
- Pelvic floor re-education/physiotherapy
- Duloxetine (caution)
- Surgery (last line)
Men:
- Artifical urinary sphincter
87
Stress incontinence causes
Women:
- Post-pregnancy trauma
Men:
- Neurogenic
- Iatrogenic (prostatectomy)
88
Management of overactive bladder
- Behavioural therapy or physiotherapy
- Anticholinergic therapy
- Mirabegron (b3 agonist)
- Botox
- Neuromodulation
- Bladder augmentation
89
What diseases can present as both nephrotic and nephritic?
- Diffuse proliferative glomerulonephritis
- Membranoproliferative glomerulonephritis
90
Aetiology of nephritic syndrome
- IgA nephropathy/Berger's disease - mc
- Post strep glomerulonephritis
- SLE
- Goodpasture's syndrome
- Haemolytic uraemic syndrome
- All examples of Type 3 hypersensitivity, except for Goodpasture's which is Type 2
91
General presentation of nephritic syndrome
- Visible/non-visible haematuria (+little proteinuria)
- Oliguria (little urine, salt + water retention)
- Hypertension
- Oedema
92
Difference in pathophysiology of nephrotic vs nephritic syndromee
Nephrotic
- Podocyte injury
- Scarring
Nephritic
- GBM breaks
- Inflammation
- Bowman crescents
93
Pathophysiology of Goodpasture's syndrome
- Presence of autoantibodies (anti-GBM) to alpha-3 chain of Type 4 collagen in glomerular and alveolar membrane
- Pulmonary and alveolar haemorrhage, lung fibrosis and glomerulonephritis
94
Treatment for Goodpasture's syndrome
- Corticosteroids
- Plasma exchange (to get rid of anti-GBM antibodies)
- Cyclophosphamide (for immune suppression)
95
Presentation of Goodpasture's syndrome
- Dyspnoea
- Coughing problems
- Oliguria
- Haematuria
96
Diagnosis of Goodpasture's syndrome
- Lung and kidney biopsy - damage and Ig deposition
- Serology - anti-GBM positive
97
Pathophysiology of Henoch Schoenlein purpura
- Small vessel vasculitis
- Affects kidney and joints due to IgA deposition
- IgA nephropathy only in kidneys
- HSP everywhere
Do biopsy
98
Presentation of Henoch Schoenlein purpura
- Purpuric rash on legs
- Nephritic symptoms
- Joint pain due to IgA deposition
99
Diagnosis of Henoch Schoenlein purpura
- Diagnosed clinically
- Confirmed with renal biopsy
100
Treatment of Henoch Schoenlein purpura
- Corticosteroids
- ACE-i/ARB
101
Risk factors for IgA nephropathy
- Asian populations
- Associated with HIV
- Teenagers or young adults
102
Presentation of IgA nephropathy
- Visible haematuria (ribena/coke)
- 1-2 days after tonsilitis
- Viral infection (or gastroenteritis viral infection)
103
Diagnosis of IgA nephropathy
- Immunofluorescence microscopy shows IgA complex deposition
- Biopsy
104
Treatment of IgA nephropathy
- Non-curative
- 30% progress to ESRF
- First line: BP control (ACE-i)
105
Diagnosis of post strep glomerulonephritis
- Light microscope - hypercellular glomeruli
- Electron microscope - subendothelial immune complex deposition
- Immunoflorescence - starry sky appearance
biopsy???
106
Presentation of post-strep glomerulonephritis
- Visible haematuria
- 2 weeks after pharyngitis from Group A, beta-haemolytic strep (S.pyogenes)
107
Complications of post strep glomerulonephritis
- Self limiting usually
- Sometimes may progress to rapidly progressing glomerulonephritis
108
Treatment of post-strep glomerulonephritis
- Antibiotics to clear the strep
- Supportive care
109
What is RPGN?
Subtype of glomerulonephritis that progresses to ESRF very fast (weeks to months)
110
Diagnosis of RPGN
Biopsy shows Inflammatory cresents in Bowman's space
111
Causes of RPGN
- Wegener's granulomatosis (c-ANCA +ve)
- MPA (pANCA +ve)
- Goodpasture's
112
Pathophysiology of SLE nephropathy
- Lupus nephritis secondary to SLE
- ANA deposition in endothelium
113
Diagnosis of SLE nephropathy
- ANA positive
- Anti-ds DNA positive
how??? bloods???
114
Treatment of SLE nephropathy
- Steroids
- Hydroxychloroquine
- plus immunosuppressants, eg: cyclophosphamide
115
Aetiology of nephrotic syndrome
Primary:
- Minimal change disease (mc in children)
- Focal segmental glomerulosclerosis (mc in adults)
- Membranous nephropathy (caucasian adults)
Secondary:
- Mc to diabetes
116
Presentation of nephrotic syndrome
- Proteinuria (frothy apple juice🧃) (>3.5g/24hours)
- Hypoalbuminaemia (<30g/L)
- Oedema (eg: puffy face)
- Hyperlipidemia + weight gain
117
Diagnosis of minimal change disease
On biopsy:
- Light biopsy = no change
- Electron biopsy = podocyte effacement + fusion
118
Diagnosis of focal segmental glomerulosclerosis
On biopsy:
- Light microscopy -> segmental sclerosis
- < 50% glomeruli affected
119
Diagnosis of membranous nephropathy
On biopsy:
- Light microscopy - thickened GBM
- Electron microscopy - subpodocyte immune complex deposition, spike + dome appearance
120
Treatment of nephrotic syndrome
- Steroids for 12 weeks with variable response
- Minimal change = responds well to them
- Focal segmental glomerulosclerosis + membranous nephropathy = less well :(
121
Supportive treatment of nephrotic syndrome
- Control fluids - diuretics, ACE-i/ARB, spironolactone
- Statins
- Anticoagulation (espesh when albumin <20g/L)
- Abx in children
122
Aetiology of calcium oxalate stones
- Low urine volume
- Hypercalciuria
- Hyperuricosuria
- Hyperoxaluria
- Hypocitraturia
123
Aetiology of calcium phosphate stones
- Low urine volume
- Hyperclciuria
- Hypocitraturia
- High urine pH
- Hyperparathyroidism
- Renal tubular acidosis
124
Drugs that impair urine composition
- Acetazolamide
- Allopurinol
- Aluminium magnesium hydroxide
- Ascorbic acid
- Calcium
- Furosemide
- Laxatives
- Vit D
- Topiramate
125
Drugs that crystallise in urine
- Allopurinol/oxypurinol
- Amoxicillin/ampicillin
- Ceftriaxone
- Ephedrine
- Indinavir
- Magnesium trisilicate
- Quinolones
- Sulphonamides
- Triamterene
- Zonisamine
126
Methods of surgery for kidney stones
- Extracorporeal shock wave lithotripsy (ESWL) - non-invasive, smaller stones
- Percutaneous nephrolithotomy (PCNL) - larger stones, 20mm+
- Uteroscopy (URS) - energy sources including lasers break up stones
- Open surgery (last resort when all else fails)
127
What are kidney stones made from?
Calcium
- Calcium oxalase (80%)
- Calcium phosphate (20%)
Other types:
- Struvite (RF = UTI) (1-5%)
- Uric acid (10-20%)
- Cystine (1%)
- Drug induced (1%)
128
Aetiology of cystine stones
Cystinuria, a genetic disorder that causes cystine to leak through the kidneys into the urine
129
Epidemiology of kidney stones
- M:F about 2:1
- Uncommon in children
- Age 30-50 but decreasing
130
Pathophysiology of kidney stones
- Excess solute in collecting duct
- Supersaturated urine, favours crystallisation
- Stones cause regular outflow obstruction
- Hydronephrosis -> dilation + obstruction of renal pelvis
131
Presentation of kidney stones
- Unilateral loin to groin pain that is colicky (fluctuating)
- Patient can't lie still (DDx = peritonitis)
- Haematuria and dysuria
- UTI symptoms/recurrent UTIs
132
Three common obstruction sites for kidney stones
- Pelvoureteric junction
- Pelvic brim (where ureter crosses over iliac vessels)
- Vesicoureteral junction
133
Diagnosis of kidney stones
First line: KUBXr - 80% specific for renal stones, cheap + easy
Gold standard: Non-contrast CT KUB - 99% specific for stones
Bloods: FBC (raised Calcium and Phosphate) U+E (haematuria)
Ultrasound if pregnant
134
Treatment for kidney stones
- Symptomatic -> hydrate, non-opiate analgesia or NSAIDs
- Antibiotics if UTI present
- Alpha blocker to help stones pass (up to 10mm)
- Surgical elective treatment if stones are too big to pass (5mm<)
135
Why shouldn't you use contrast agent when kidney disease is suspected?
Contrast would need to be excreted by the kidney
136
Prevention of uric acid stones
Deacidification of urine to pH 7-7-5
137
Prevention of cystine stones
- Excessive overhydration
- Urine alkalinisation
- Cysteine binders
138
Pathophysiology of obstructive uropathy
- Obstruction
- Retention and increased kidney ureter bladder (KUB) pressure
- Refluxing/backlogged urine in renal pelvis
- Hydronephrosis - dilated renal pelvis, more infection prone
139
Most common causes of obstructive uropathy
- Benign prostatic hyperplasia
- Kidney stones
140
Treatment of obstructive uropathy
- Relieve kidney pressure -> catheterise urethra, urethral stent
- Treat cause/infection
141
Autosomal recessive PKD
- Much less common
- Mutated PKHD1 gene on chromosome 6
- Infancy or prebirth
- High mortality
- Congenital abnormalities
- eg: Potter's sequence: flattened nose + clubbed feet
142
Autosomal dominant PKD
- Most common
- Mutated PKD1 (85%) or PKD2 (15%)
- More males
- Presentation at 20-30 years
143
Pathophysiology of polycystic kidney disease
Normally
- PKD 1+2 codes for polycystin (Ca2+ channels)
- Usually, cilia move and polycystin open
- Ca2+ influx inhibits excessive growth
PKD
- PKD gene mutated
- Lack of Ca2+ influx
- Excessive growth of cilia
- Results in polycysts
144
What is PKD?
- Cyst formation through renal parenchyma
- Bilateral enlargement and damage
145
Presentation of PKD
- Bilateral flank/back or abdo pain
- Hypertension
- Haematuria (when cysts rupture), resolves within a few days
- Renal stones more common
- End stage renal failure at around 50 years
146
Extrarenal cysts
- Particularly in Circle of Willis
- Berry aneurysm if rupture -> subarachnoid haemorrhage
147
Diagnosis of PKD
- Kidney ultrasound shows enlarged bilateral kidneys with multiple cysts
- Also genetic testing
148
Treatment of PKD
- Non-curative
- Manage symptoms
149
What is a consequence of autosomal dominant PCKD?
IBS
150
What is retention?
Inability to pass urine even when bladder is full (500+mL)
151
Causes of retention
- Obstruction
- Stones
- BPH
- Neurological flaccid paralysis
(hypotonia of detrusor, as LMN)
152
Treatment of retention
Catheterise
153
What does a scrotal mass indicate?
Cancer until proven otherwise
154
What is an epididymal cyst?
- Extratesticular cyst above and behind testis
- Transilluminates
- Diagnosed by scrotal ultrasound
- Dissolves in 10 days
155
Presentation of epididymitis
- Acute unilateral pain
- Sometimes following previous infection
- Prehn's sign positive
156
Treatment of epididymitis
- Stat IM ceftriaxone (if organism unknown)
- Plus doxycyline
157
What is hydrocele?
- Cyst that testicle sits within
- Transilluminates
- Diagnosed with scrotal ultrasound
158
Pathophysiology of hydrocele
Fluid collection in tunica vaginalis
159
Pathophysiology of testicular torsion
- Spermatic cord twists on itself
- Occlusion of testicular artery
160
Risk factor for testicular torsion
Bell clapper deformity ("horizontal lie" of testes)
161
Presentation of testicular torsion
- Severe unitesticular pain - hurts when walking
- Abdo pain
- Nausea and vomiting
- Cremastering reflex lost
- Prehn's negative
162
Diagnosis of testicular torsion
- First, surgical exploration
- Then, ultrasound to check testicular blood flow
163
Treatment of testicular torsion
- Urgent surgery within 6 hours (90-100% successful)
- All cases require bilateral orchiplexy (fixing of scrotal sac to overcome biclapper deformity)
- If testes non-viable = orchidectomy
164
Pathophysiology of varicocele
- Distended pampiniform plexus
- Due to increased left renal vein pressure causing reflux
165
Complication of varicocele
Infertility
166
Presentation of varicocele
- Bag of worms (on left hand side mostly)
- Typically painless, painful when more severe
- Diagnosed clinically
167
Presentation of chlamydia and gonorrhoea
- Vaginitis and cervicitis
- Proctitis
- Epididymo-orchitis
- Pelvic inflammatory disease
- Pharyngitis
- Reactive arthritis
168
What do GUM clinics screen for?
- Chlamydia
- Gonorrhoea
- Syphilis (blood test)
- HIV (blood test)
169
How do nucleic acid amplification tests work?
- Check if a gonococcal infection is present or not
- By looking at gonococcal RNA or DNA
170
Reactive arthritis (Reiter's triad)
- Can't see - conjunctivitis
- Can't pee - urithritis
- Can't climb a tree - arthritis
171
Treatment for chlamydia
- First line: doxycycline
- If CI or not tolerated: azithromycin
- If CI: erythromycin...or ofloxacin but this is CI in pregnancy
- Sexual intercourse should be avoided until treatment is complete
- Partner must also be treated
172
What is chlamydia caused by?
Chlamydia trachomatis, a gram negative intracellular bacillus
173
Epidemiology and risk factors for chlamydia
- Most common STI in the UK
- Under 25 and sexually active
- New sexual partner or more than one sexual partner in the last year
- Lack of consistent condom use
- Unprotected sex
174
Symptoms of lymphogranuloma venereum (a type of chlamydia)
- Tenesmus
- Anorectal discharge (often bloody) and discomfort
- Diarrhoea or altered bowel habits
175
Diagnosis of chlamydia
Nucleic acid amplification testing
- Women - vulvovaginal or endocervical swab
- Men - first-void urine
176
Symptoms in chlamydia
70% of women and 50% of men are asymptomatic
177
Treatment for gonnorrhoea
- IM ceftriaxone 1g
- Refer to GUM clinic
178
What is gonorrhoea caused by?
- Gram-negative diplococcus Neisseria gonorrhoeae
- Spread by penetretive sexual intercourse most commonly
179
Risk factors for gonorrhoea
- Frequent or unprotected sexual intercourse
- Multiple sexual partners
- MSM
- Chlamydial infection
180
Symptoms in gonorrhoea
50% of women and 90% of men are symptomatic
181
Symptoms of rectal and pharyngeal gonorrhoea infection
- Rectal infection is usually asymptomatic but may cause anal discharge and pain or discomfort
- Pharyngeal is asymptomatic in most cases but is occasionally associated with a sore throat
182
Diagnosis of gonorrhoea
- Nucleic acid amplifiction testing
- Microscopy shows gram negative diplococci
- Swab infected areas
183
Treatment for early syphilis
- Single deep intramuscular dose of benzathine benzylpenicillin
- Refer to GUM clinic
- Notify all partners in the last 3 months
184
Pathophysiology of syphilis
- Spirochete bacteria called Treponema pallidumial
- Gets in through skin or mucous membranes, replicates and then disseminates through the body
185
Risk factors for syphilis
- MSM
- IVDU
- Sex workers
- Multiple or unprotected sexual partners
186
Primary syphilis
- Painless ulcer called a 'chancre' at the original site of infection (usually genitals)
- Femoral lymphadenopaty
- Presents 9-90 days after exposure
- Usually resolves spontaneously over 3-10 weeks
187
Secondary syphilis
- Systemic features, skin lesions, alopecia, mucous patches and early neurosyphilis
- Presents 4-12 weeks after initial chancre
- Untreated symptoms slowly resolve over 3-12 weeks but may recur
188
Latent syphilis
- Asymptomatic
- Less than 2 years duration from initial infection
- Late latent - more than 2 years
189
Tertiary syphilis
- Gummatous, cardiovascular and neuro syphilis
- Presents 15-40 years after initial infection
190
Diagnosis of syphilis
- Antibody testing for T.pallidum
- Samples from site of infection can be tested to confirm the presence of T.pallidum with dark field microscopy and PCR
191
Five most common UTI pathogens
Klebsiella
E.coli
Enterobacter
Proteus
S.saphrophyticus
MC is uropathogenic e.coli
192
Why are females more affected by UTIs?
- Shorter urethra
- Closer to anus
- Easier for bacteria to colonise
193
Diagnosis of all types of UTI
First line:✨Urine dipstick✨
+ve leukocytes
+ve nitrites (bc bacteria break down nitrates into nitrites)
+/- haematuria
Gold standard: Midstream MC + S
- Confirms UTI
- Identifies pathogen
194
Complicated vs uncomplicated UTIs
Uncomplicated - non pregnant women
Complicated - everyone else
195
Teatment of asymptomatic bacteruria
Do not treat if they’re over 65 (???)
196
What to do while waiting UTI test results
First line (trimethroprim) if patient is symptomatic
197
Diagnosis of urethritis, epididymo-orchitis and prostatitis
- Normal diagnosis for UTIs
- As well as NAAT (nucleuc acid amplification testing) to detect STI
198
Treatment of urethritis and epididymo-orchitis
Dependent on cause
199
What is pyuria?
The presence of leukocytes in the urine
200
What is cystitis?
- UPEC infection of the bladder
- Most common in young sexually active women
201
Aetiology of cystitis
- Urine stasis
- Bladder lining damage
- Catheters
202
Presentation of cystitis
- Suprapubic tenderness and discomfort, worse with a full bladder
- High frequency and urgency
- Visible haematuria
203
Treatment for cystitis
- Trimethroprim (avoid in pregnancy) or nitrofurantoin (avoid in 3rd trimester)
- If pregnant, take amoxicillin instead
204
What is epididymo-orchitis?
- Inflammation of the epididymis, extending to the testes
Usually due to:
- Urethritis (<35 years)
- Cystitis extension (>35 years)
- Can also be caused in the elderly from a catheter
205
Presentation of epididymo-orchitis
- Unilateral scrotal pain and swelling
- Prehn’s sign positive
- Cremaster reflex intact
- DDx = rule out testicular torsion
206
Treatment for epididymo-orchitis
Depends on if it's caused by an STI (NG/CT) or UTI - treat either appropriately
207
Acute vs chronic prostatitis
- Acute bacterial prostatitis - more rapid onset of symptoms
- Chronic prostatitis - symptoms lasting for at least 3 months, can be subdivided.
Types of chronic prostatitis:
- Chronic pelvic pain syndrome - no infection
- Chronic bacterial prostatitis - infection
208
Most common cause of prostatitis
E.Coli
209
Presentation of prostatitis
- Perineal, penile or rectal pain
- Acute urinary retention, obstructive voiding symptoms
- Low back pain, pain on ejaculation
- Tender, swollen warm prostate on examination
210
Infective vs non-infective urethritis
Infective: Gonococcal (LC) and non-gonococcal (MC, chlamydia)
Non-infective: Trauma
211
Risk factors for urethritis
MSM and unprotected sex
212
Presentation of lower urinary tract infections
- Dysuria
- Frequency
+/- urethral discharge, urethral pain (Urethritis)
213
Treatment for urethritis
- N.Gonorrhoea - IM ceftriaxone or azithromycin
- C.Trachomatis - azithromycin (or doxycycline)
214
Investigations for upper UTI
- Midstream urine
- Blood cultures
215
Treatment for pyelonephritis
- Analgesia: Paracetamol
- Antibiotics: Ciprofloxacin or co-amoxiclav
(if pregnant, give cefalexin)
- Refer to hospital if there are signs of sepsis
216
What is pyelonephritis?
Infection of the renal parenchyma and upper ureter, ascending transurethral spread
217
Most common causative pathogens of pyelonephritis (most to least common)
- Uropathogenic E.Coli
- Kleblsiella
- Proteus
- Pseudomonas
- Enterobacter
218
Presentation of pyelonephritis
Triad: loin pain, fever, n+v
219
Patients who have significant symptoms or do not respond to treatment w pyelonephritis
- Renal abscess
- Kidney stones
220
Complication of pyelonephritis
Hydronephritis from dilated renal pelvis
