GU review

Question 1

LFT elevation renal mass mechanism

Answer 1

Paraneoplastic syndrome called Stauffers syndrome

Question 2

renal medullary cancer-associated disorder

Answer 2

sickle cell trait

Question 3

first-line treatment for medullary renal cancer

Answer 3

carbo/gem

Question 4

stain markers that differentiate urothelial from RCC

Answer 4

CK7 and CK20 are positive in urothelial but usually negative in RCC

Question 5

papillary RCC mutation

Answer 5

c-MET

Question 6

BAP-1 gene tumor predisposition syndrome cancer types

Answer 6

clear cell RCC, uveal melanoma, cutanous melanoma, mesothelioma

Question 7

Birt-Hogg-Dube syndrome cancer types and benign conditions, mutation

Answer 7

chromophobe tumors, hybrid oncolytic tumors, clear cell tumors, oncocytoma, papillary tumors and angiomyolipomas

lung blebs–> pneumothorax

FLCN gene (folliculin tumor suppressor gene)

Question 8

VHL syndrome tumor types

Answer 8

clear cell RCC (bilateral and young), pancreatic neuroendocrine tumors, pheochromocytomas, hemangioblastomas (blindness), endolymphatic sac tumors (inner ear–>hearing loss)

Question 9

tuberous sclerosis tumors, gene, other findings

Answer 9

Clear cell RCC, angiomyolipomas, oncocytic tumors, renal cysts, CNS tubers, subependymal giant cell astrocytoma, retinal harmartomas, cardiac rhabdomyoma

light skin, raised thickened growths, autism, shagreen patch, ungual fibromas

TSC1 or 2

Question 10

hereditary leiomyomatosis and RCC syndrome tumors

Answer 10

leiomyomas in skin, uterus, fumartate hydratase deficient RCC, adrenal adenomas

Question 11

treatment for angiomyolipomas in tuberous sclerosis complex

Answer 11

everolimus