Guest speaker – cancer immunology research

Question 1

What is immune surveillance?

Answer 1

Recognition & elimination of transformed cells

This process involves the immune system identifying and destroying cells that have undergone malignant transformation.

Question 2

What is immune evasion in the context of cancer?

Answer 2

Tumor cells begin to escape detection by immune cells

This allows cancer cells to proliferate and survive despite the immune response.

Question 3

Define anti-tumor immunity.

Answer 3

Immune cells mount response against tumors to kill tumor cells

This involves various immune mechanisms targeting and destroying cancerous cells.

Question 4

What is the significance of immune checkpoint inhibition in cancer therapy?

Answer 4

New era in cancer therapy

Immune checkpoint inhibitors help to enhance the immune response against tumors.

Question 5

What challenge does tumor heterogeneity pose?

Answer 5

Challenges for universal therapeutic approaches

Different tumor microenvironments can affect treatment efficacy.

Question 6

List the types of tumor microenvironments mentioned.

Answer 6

• Infiltrated – excluded
• Infiltrated – inflamed
• Infiltrated - TLS

These categories describe how immune cells interact with tumors.

Question 7

What is mass cytometry used for?

Answer 7

Detect expression of up to 45 protein targets on single cells

This technique allows for detailed analysis of cellular characteristics and functions.